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Quantitative imaging system and uses thereof

An imaging and image technology, applied in radio wave measurement systems, applications, patient positioning, etc.

Pending Publication Date: 2021-01-26
托莫维实验室有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The fiber optic bundle is configured to deliver instantaneous pulses of laser light with maximum transmission throughout the tissue region of interest

Method used

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  • Quantitative imaging system and uses thereof
  • Quantitative imaging system and uses thereof
  • Quantitative imaging system and uses thereof

Examples

Experimental program
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example 1

[0104]Functional imaging verification of the model

[0105]Compared with the previously reported system, the most important advancement of this latest system design is the use of fiber optic illuminators (independent of the rotation of the detector probe, rotation around the breast) for each rotation step of the photoacoustic transducer. Whole breast irradiation. This article reports a pilot case study of a healthy volunteer and a patient with suspected small breast lesions. LOUISA visualizes the hypoxic veins and oxygenated arteries of healthy volunteers, thereby indicating the ability to visualize the hypoxic microvessels of cancerous tumors. The small lesions detected on the photoacoustic image of the patient are not visible on ultrasound, thereby potentially indicating the high system sensitivity of the photoacoustic subsystem to small but aggressive growth of cancerous lesions (with high density of angiogenic microvessels) Sex. Using a safe level of NIR optical fluence, the main ...

example 2

[0110]Clinical validation of LOUISA

[0111]The LOUISA system includes a 3D imaging module and a 2D imaging handheld probe. Although LOIS-3D (the predecessor of LOUISA) uses a half-time reconstruction algorithm in spherical coordinates(30), But must adopt full-time reconstruction for the hemispherical geometry of 3D image reconstruction to maintain the full view of breast imaging. Strict reconstruction solution(31). The patient’s image was acquired at a single wavelength of 757 nm, so blood oxygen saturation of blood vessels and tumors is impossible. 2 out of 3 projections (Figure 6A to Figure 6B Instead ofFigure 6C ) The nature of the visible smaller (3.5mm) tumors has not been explored conclusively.Figure 6A to Figure 6C It is the specific display of LOUISA sensitivity rather than tumor difference.

[0112]Various improvements in the imaging module design and enhancement of signal processing and image reconstruction algorithms result in high-contrast and high-resolution images of the b...

example 3

[0115]LOUISA3D for breast cancer care as an example of QT system

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Abstract

Provided herein are imaging systems such as a system for quantitative tomography and a laser optoacoustic ultrasonic imaging system assembly (LOUISA) for imaging a tissue region, for example, a breastin a subject. Generally, the system components are a laser that emits instant pulses of laser light in a wavelength cycling mode, fiberoptic bundles or optical arc-shaped fiber bundles configured todeliver laser light, an imaging module with an imaging tank, an optoacoustic array(s) of ultrawide-band ultrasonic transducers and ultrasound array(s) of ultrasonic transducers and a coupling medium and an electronics subsystem. Also provided is a method for imaging quantitative functional parameters and / or molecular parameters and anatomical structures in a tissue volume of interest, such as a breast, in a subject utilizing the system for quantitative tomography.

Description

[0001]Cross references to related applications[0002]This international application is filed on April 4, 2018 in accordance with 35 USC §119(e) in the priority rights of U.S. Provisional Application Serial No. 62 / 652,337, and the entire content of the provisional patent application is hereby incorporated by reference .[0003]Federal funding description[0004]The present invention was completed with government support, and the grant number granted by the National Institutes of Health is R01CA167446. The government has certain rights in the invention.Technical field[0005]The present invention relates to the field of biomedical imaging and tomography systems, which can provide medical information about the volume of interest area of ​​the examined body. More specifically, the present invention provides a laser photoacoustic ultrasound imaging system assembly (LOUISA) that is used for quantitative three-dimensional tomography of a subject's tissue region of interest to obtain anatomical im...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B6/03A61B8/08
CPCA61B8/08A61B5/0033G01S15/8915A61B5/0073A61B2576/00A61B8/0825A61B5/0095A61B8/5223A61B5/0091A61B8/5261A61B8/5246A61B8/483A61B8/4483A61B8/40A61B8/4272A61B8/463A61B8/0808A61B8/481G01S15/8965G01S15/8993G01S15/894A61B8/085G01S7/521A61B8/0858
Inventor A·A·奥拉耶夫斯基
Owner 托莫维实验室有限公司
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