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Composition for muscle relaxation

一种肌肉松弛、组合物的技术，应用在药物组合、肌肉系统疾病、神经肌肉系统疾病等方向，能够解决治疗效果丧失等问题

Active Publication Date: 2021-02-12
CAREGEN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This is a very serious problem due to the formation of antibodies against botulinum toxin which can lead to a significant loss of therapeutic effect

Method used

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  • Composition for muscle relaxation
  • Composition for muscle relaxation
  • Composition for muscle relaxation

Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

[0108] Preparation Example 1. Preparation of Novel Peptides with Various Physiological Activities

[0109] A novel peptide sequence "KFLIK" having an amino acid sequence represented by SEQ ID NO: 1 was prepared using a known method. The novel peptide has a molecular weight of 647.4 Da.

experiment example 1

[0110] Experimental example 1. Evaluation of high temperature stability of peptides

[0111] 1-1. Evaluation of high-temperature stability during long-term storage

[0112] The peptide of the present invention having the amino acid sequence of SEQ ID NO: 1 was dissolved in sterile distilled water at a concentration of 1,000 ppm, stored at 45° C. for 7 days, 14 days, 28 days, 60 days, and 75 days, and then subjected to HPLC analysis .

[0113] As a result, such as figure 1 As shown, it can be seen that under the condition of 45°C, the stability of the peptide of the present invention is maintained during the longest observation period of 75 days.

[0114] 1-2. Evaluation of high temperature stability

[0115] The peptide of the present invention was dissolved in sterile distilled water at a concentration of 1,000 ppm, warmed at 121° C. for 15 minutes and 30 minutes, and then subjected to HPLC analysis.

[0116] As a result, such as figure 2 As shown, it can be seen that t...

experiment example 2

[0117] Experimental Example 2. Confirmation of the Decomposition Degree of Syntaxin 1A by the Action of Peptides Soluble N-ethylmaleimide-sensitive factor-attached protein receptor (SNARE) protein is involved in membrane fusion that occurs in cells . Neuronal SNAREs involved in neurotransmission are associated with the binding of synaptic vesicles to the presynaptic membrane. Synaptic vesicles that carry neurotransmitters and simultaneously release neurotransmitters should fuse with the presynaptic membrane to form neurotransmitter release channels. In this case, fusion occurs by means of SNAREs that exist as protein complexes. In particular, the t-SNARE complex (which is a complex of the SNAP-25 protein and the syntaxin 1A protein attached to the target membrane) and the v-SNARE attached to the vesicle participate in this fusion. Membrane fusion fails when the SNARE conjugation and twisting process is not sufficiently completed. As a result, the muscles relax because the n...

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Abstract

The present invention relates to a peptide exhibiting physiological activity and a composition comprising the same peptide. The peptide of the present invention exhibits various physiological activities such as muscle relaxation, reduction of skin wrinkles, inhibition of sebum generation, and the like and as such, can be used as an active ingredient in a pharmaceutical composition for muscle relaxation or in a cosmetic for alleviation of skin wrinkles, inhibition of sebum generation or reduction of acne.

Description

technical field [0001] The present invention relates to a physiologically active peptide and a composition comprising the peptide, more specifically, the present invention relates to a combination for muscle relaxation or for improving skin wrinkles, inhibiting sebum production, or improving acne A substance (eg, a pharmaceutical composition or a cosmetic composition) comprising the physiologically active peptide. Background technique [0002] Neurons (ie, nerve cells) that make up an animal's nervous system have axons that have unique structures not found in other cells. An axon is a long, thin structure that protrudes from the nerve cell body so that the axon is connected to the target neuron through which signal transmission and material transfer take place. [0003] The neuromuscular synapse has a specifically differentiated synaptic structure in which the terminal synapse of the axon connects to the skeletal muscle cell for impulse transmission from the neuron to the m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/64A61Q19/08A61K38/08A61P21/02A61Q17/00
CPCA61K8/64A61P21/02A61Q19/08A61Q19/008A61K38/08A61K9/1652A61K9/2018A61K9/4866A61K9/4825A61K9/2059A61K9/0014A61Q17/00C07K7/06
Inventor 郑镕池金银美李应智
Owner CAREGEN
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