Compositions and methods for enhancing the killing of target cells by nk cells

一种NK细胞、B细胞的技术，应用在化学仪器和方法、抗受体/细胞表面抗原/细胞表面决定因子免疫球蛋白、药物组合等方向，能够解决患者不适合免疫疗法等问题
CN112384534APending Publication Date: 2021-02-19COMPASS THERAPEUTICS LLC
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
COMPASS THERAPEUTICS LLC
Publication Date
2021-02-19

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Abstract

The present disclosure provides immunotherapeutic compositions and methods for enhancing an immune response and for treating cancer or inflammatory conditions mediated by autoreactive B cells in a subject. In some aspects, multispecific antigen-binding constructs are provided that recognize at least one tumor antigen or B-lineage cell antigen and NKp30 and / or another activating NK receptor. In some aspects, multispecific antigen-binding constructs are provided that recognize at least two tumor antigens or two antigens expressed by B-lineage cells, NKp30, and another activating NK receptor. Themultispecific antigen-binding constructs and methods disclosed herein can be used for the treatment of cancer, even a cancer characterized by a CD16 deficient microenvironment and / or characterized bytarget cells (e.g., cancer cells) having a low level of expression of the tumor antigen.
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Description

[0001] Cross References to Related Applications

[0002] This application claims U.S. Provisional Patent Application No. 62 / 674,289 filed May 21, 2018; U.S. Provisional Patent Application No. 62 / 674,279 filed May 21, 2018; U.S. Provisional Patent Application No. 62 / 674,286; U.S. Provisional Patent Application No. 62 / 728,542 filed September 7, 2018; U.S. Provisional Patent Application No. 62 / 731,030 filed September 13, 2018; U.S. Provisional Patent Application No. 62 / 731,045 filed on the 13th; U.S. Provisional Patent Application No. 62 / 731,047 filed on September 13, 2018; U.S. Provisional Patent Application No. 62 / 756,012 filed on November 5, 2018; U.S. Provisional Patent Application No. 62 / 760,473, filed November 13, 2018; U.S. Provisional Patent Application No. 62 / 760,670, filed November 13, 2018; U.S. Provisional Patent Application No. 62, filed November 13, 2018 / 760,644; U.S. Provisional Patent Application No. 62 / 767,786, filed November 15, 2018; U.S. Provisional Patent App...

Claims

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