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Cyclopentane compounds

A compound, cyclopentyl technology, applied in the field of cyclopentane compounds, can solve the problems of no TRPC6, no dual inhibitors of TRPC6 and TRPC3, etc.

Active Publication Date: 2021-02-26
DIZAL JIANGSU PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] To our knowledge, to date there are no inhibitors of TRPC6 or TRPC3, and no dual inhibitors of TRPC6 and TRPC3 approved for clinical use

Method used

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  • Cyclopentane compounds
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Experimental program
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Embodiment Construction

[0169] The compounds of the present application will now be further explained with reference to the following non-limiting examples.

[0170] 1H NMR measurements were performed on a Bruker Avance spectrometer at 300 and 400 MHz 1 Operates at H frequency. Experiments are typically recorded at 25°C. Chemical shifts are given in ppm with solvent as internal standard. HPLC is typically performed on a Shimadzu UHPLC coupled with DAD detector, ELSD detector and 2020EV MS or a Shimadzu UFLC coupled with DAD detector, ELSD detector and 2020EV MS. Use normal phase silica FLASH+ TM (40M, 25M or 12M) or SNAP TM KP-Sil Cartridges (340, 100, 50 or 10), using CIS-Flash columns or Standard Flash, in Biotage TM SP1 TM Flash chromatography was performed using normal phase flash chromatography on the purification system. In general, all solvents used were commercially available and of analytical grade. Anhydrous solvents are usually used for the reactions. The phase separator used in t...

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Abstract

The present invention relates to cyclopentane compounds of Formula (I), physical forms thereof, processes for their production and their use in medicine.

Description

[0001] field of invention [0002] The present disclosure relates to substituted cyclopentane compounds and pharmaceutically acceptable salts thereof, which inhibit the canonical transient receptor potential channels TRPC6 and TRPC3. The present disclosure also relates to the use of these compounds and pharmaceutically acceptable salts thereof in medicine, eg for the treatment of diseases for which inhibition of TRPC6 or TRPC3 function is of therapeutic interest. The present disclosure also relates to methods of treatment and methods of preparing medicaments using the compounds according to the present disclosure. Background technique [0003] Transient receptor potential channels (TRP channels) are a group of ion channels located mostly on the plasma membrane of certain mammalian cells. TRP channels normally regulate ion entry drive and Ca in the plasma membrane 2+ and Mg 2+ transport mechanism. Seven canonical transient receptor potential channels (TRPC channels) are pot...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D401/08C07D211/56A61P13/12A61K31/451A61K31/454A61K31/4545
CPCC07D211/56C07D401/08A61P13/12Y02P20/55A61K31/454C07B2200/13
Inventor 张小林潘伟涛G·尼奇迪斯J·S·M·林德哈根
Owner DIZAL JIANGSU PHARMA CO LTD