Silicon dioxide adsorbent for vitamin carrier and preparation method thereof

A technology of silicon dioxide and vitamins, applied in the directions of silicon dioxide, silicon oxide, chemical instruments and methods, etc., can solve the problems of no flow aid and anti-caking effect, small adsorption capacity, low particle surface energy, etc. The effect of flow and anti-junction effect, controllable conditions, and simple and easy-to-operate preparation method

Active Publication Date: 2021-03-09
GUANGZHOU FEIXUE MATERIAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, silica with a small particle size of D50 has a low apparent density (≤0.2g/mL), and the flow-aiding effect is insufficient.
[0004] The patent publication No. US4717561A discloses a precipitated silica vitamin carrier, the particle size D50=0.14-0.25mm, the specific surface area=140-160m 2 /g, oil absorption value (dibutyl phthalate oil)=160-220mL/100g, although the specific surface area of ​​this kind of silicon dioxide vitamin ...

Method used

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  • Silicon dioxide adsorbent for vitamin carrier and preparation method thereof
  • Silicon dioxide adsorbent for vitamin carrier and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Embodiment 1, a kind of preparation method of silica adsorbent for vitamin carrier

[0031] The preparation method of the silica adsorbent for the vitamin carrier comprises the following steps:

[0032] S1. After liquefying solid sodium silicate with a modulus of 1.5 at high temperature, add water to form a sodium silicate solution with a concentration of 1.10mol / L;

[0033] S2, configuration concentration is the sulfuric acid solution of 2.50mol / L;

[0034] S3, add 8m in the reactor 3 of tap water, then add 1m 3 The sodium silicate solution prepared in step S1 is heated to 65°C, the stirring device is turned on, the stirring frequency is 50Hz, and the sulfuric acid solution prepared in step S2 is added dropwise at a rate of 2 m 3 / h, the control reaction terminal pH value is 7.5;

[0035] S4, continue to drip the sodium silicate solution that step S1 makes and the sulfuric acid solution that step S2 makes in reaction system, the rate of addition of sodium silicate ...

Embodiment 2

[0037] Embodiment 2, a kind of preparation method of silica adsorbent for vitamin carrier

[0038] The preparation method of the silica adsorbent for the vitamin carrier comprises the following steps:

[0039] S1. After liquefying solid sodium silicate with a modulus of 3.5 at high temperature, add water to form a sodium silicate solution with a concentration of 1.80mol / L;

[0040] S2, configuration concentration is the sulfuric acid solution of 6.50mol / L;

[0041] S3, add 12m in the reactor 3 of tap water, then add 3m 3 The sodium silicate solution prepared in step S1 is heated to 90°C, the stirring device is turned on, the stirring frequency is 60 Hz, and the sulfuric acid solution prepared in step S2 is added dropwise at a rate of 5 m 3 / h, the pH value of the control reaction end point is 10.0;

[0042] S4, continue to drip the sodium silicate solution that step S1 makes and the sulfuric acid solution that step S2 makes in reaction system, the rate of addition of sodiu...

Embodiment 3

[0044] Embodiment 3, a kind of preparation method of silica adsorbent for vitamin carrier

[0045] The preparation method of the silica adsorbent for the vitamin carrier comprises the following steps:

[0046] S1. After liquefying solid sodium silicate with a modulus of 2.1 at high temperature, add water to form a sodium silicate solution with a concentration of 1.34mol / L;

[0047] S2, configuration concentration is the sulfuric acid solution of 4.30mol / L;

[0048] S3, add 9m in the reactor 3 of tap water, then add 2m 3 The sodium silicate solution prepared in step S1 was heated to 75 °C, the stirring device was turned on, the stirring frequency was 54 Hz, and the sulfuric acid solution prepared in step S2 was added dropwise at a rate of 3 m 3 / h, the control reaction terminal pH value is 8.0;

[0049] S4, continue to drip the sodium silicate solution that step S1 makes and the sulfuric acid solution that step S2 makes in reaction system, the rate of addition of sodium sil...

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Abstract

The invention belongs to the technical field of silicon dioxide, and particularly relates to a silicon dioxide adsorbent for a vitamin carrier and a preparation method thereof. Water is used as a reaction base solution, a water glass solution with the modulus of 1.5-3.5 and a sulfuric acid solution are used as reaction raw materials, polyethylene glycol with the mass percent of 0.01-0.1% is used as a reaction aid, and the precipitated silicon dioxide adsorbent for the vitamin carrier with the low specific surface area and the high oil absorption value is prepared. The specific surface area ofthe silicon dioxide adsorbent for the vitamin carrier is 140-200 m<2>/g, the D50 particle size is 20-70 microns, the VE oil absorption value is 240-300 g/100 g, the apparent density is 0.2-0.6 g/mL, alarge amount of vitamins can be adsorbed after the silicon dioxide adsorbent is mixed with the vitamins, the system is stable after adsorption, and powder has excellent flow aiding and anti-caking effects in the vitamin preparation process.

Description

technical field [0001] The invention belongs to the technical field of silicon dioxide, and in particular relates to a silicon dioxide adsorbent for vitamin carriers and a preparation method thereof. Background technique [0002] Lipids can be widely used in the field of pharmaceutical products as drug solubilizers to improve the oral availability of poorly soluble drugs. Liquid vitamins are convenient for humans and animals to absorb and utilize, but they are expensive to manufacture and transport, and risky to use. Solid vitamins are not easy for the body to absorb, but they are low in cost and easy to store and transport. Therefore, the main challenge of lipid drug formulations such as vitamins is to convert oil-based solutions and liquid formulations into compressible solid or semi-solid formulations to facilitate the storage, transportation and administration of drugs, while improving the absorption and utilization of humans and animals . One of the most commonly use...

Claims

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Application Information

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IPC IPC(8): B01J20/10B01J20/30C01B33/12
CPCB01J20/103B01J2220/4806B01J2220/4812C01B33/12
Inventor 梁少彬马逸敏侯灿明林英光胡非
Owner GUANGZHOU FEIXUE MATERIAL TECH
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