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Compound traditional Chinese medicine gel el containing podophyllotoxin and preparation method thereof

A technology of podophyllotoxin and compound traditional Chinese medicine, which can be applied to medical preparations containing active ingredients, medical preparations without active ingredients, antiviral agents, etc., and can solve the problems of low dispersion uniformity, complex process, short action time, etc. , to achieve the effect of enhancing the dispersion uniformity, the preparation process is simple, and the product quality is stable.

Pending Publication Date: 2021-03-12
广西达庆生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, in order to reduce the irritation of podophyllotoxin tincture to the skin and improve its shortcomings such as short action time, podophyllotoxin gel has been developed
[0004] For example, Chinese invention CN201510837328.3 discloses a compound podophyllotoxin gel for treating HPV virus and its preparation method. In this method, the drug is dissolved in ethanol, and the carbomer is swelled with purified water to make a gel matrix, and then the The ethanol solution in which the drug is dissolved is directly mixed with the gel matrix. Since podophyllotoxin is insoluble in water, this method can easily cause the problem of podophyllotoxin precipitation and low dispersion uniformity when the drug is mixed with the matrix, thus affecting the curative effect
And this invention utilizes medicine to corrode the superficial cells infected by HPV in condyloma acuminatum, and the HPV virus in its deep cells cannot be effectively removed, and it is easy to relapse
[0005] Another example is the Chinese invention CN201510793711.3 which discloses a preparation method and application of podophyllotoxin transdermal drug delivery preparation. This method is complex in process and high in manufacturing cost.
It also acts on the superficial cells of genital warts and cannot effectively remove the deep HPV virus, which may easily cause the recurrence of genital warts

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] A preparation method of a compound Chinese medicine gel containing podophyllotoxin, the preparation method of the compound Chinese medicine gel comprises three parts:

[0032] The first part is the preparation of the gel matrix: Weigh purified water, glycerin, propylene glycol and ethanol, mix and stir evenly, add Chinese herbal extracts and borax, stir until all materials are dissolved, then sprinkle carbomer into the solution, and swell for more than 12 hours , wherein, the parts by weight of purified water, glycerin, propylene glycol, ethanol, Chinese medicine extract, borax, and carbomer are 500, 100, 20, 80, 30, 2, 8;

[0033] The second part is the preparation of podophyllotoxin ethanol solution: successively weigh podophyllotoxin and borneol and add them to ethanol, stir and dissolve to make podophyllotoxin ethanol solution, wherein the weight parts of podophyllotoxin, borneol and ethanol are 5, 2, 70;

[0034] The third part is the mixing of podophyllotoxin sol...

Embodiment 2

[0039] A preparation method of a compound Chinese medicine gel containing podophyllotoxin, the preparation method of the compound Chinese medicine gel comprises three parts:

[0040] The first part is the preparation of the gel matrix: Weigh purified water, glycerin, propylene glycol and ethanol, mix and stir evenly, add Chinese herbal extracts and borax, stir until all materials are dissolved, then sprinkle carbomer into the solution, and swell for more than 12 hours , wherein, the parts by weight of purified water, glycerin, propylene glycol, ethanol, Chinese medicine extract, borax, and carbomer are 550, 150, 30, 100, 50, 3, 10;

[0041] The second part is the preparation of podophyllotoxin ethanol solution: successively weigh podophyllotoxin and borneol and add them to ethanol, stir and dissolve to make podophyllotoxin ethanol solution, wherein the weight parts of podophyllotoxin, borneol and ethanol are 7, 4, 80;

[0042] The third part is the mixing of podophyllotoxin s...

Embodiment 3

[0047] A preparation method of a compound Chinese medicine gel containing podophyllotoxin, the preparation method of the compound Chinese medicine gel includes three parts:

[0048]The first part is the preparation of the gel matrix: Weigh purified water, glycerin, propylene glycol and ethanol, mix and stir evenly, add Chinese herbal extracts and borax, stir until all materials are dissolved, then sprinkle carbomer into the solution, and swell for more than 12 hours , wherein, the parts by weight of purified water, glycerin, propylene glycol, ethanol, Chinese medicine extract, borax, and carbomer are 600, 200, 50, 120, 60, 5, 12;

[0049] The second part is the preparation of podophyllotoxin ethanol solution: successively weigh podophyllotoxin and borneol and add them to ethanol, stir and dissolve to make podophyllotoxin ethanol solution, wherein the weight parts of podophyllotoxin, borneol and ethanol are 8, 5, 90;

[0050] The third part is the mixing of podophyllotoxin sol...

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PUM

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Abstract

The invention relates to the technical field of traditional Chinese medicine gel, in particular to compound traditional Chinese medicine gel containing podophyllotoxin and a preparation method of thecompound traditional Chinese medicine gel, the preparation process is simple and convenient, the product quality is stable, a solution obtained after traditional Chinese medicine extracts are dissolved is used for swelling carbomer, the dispersion uniformity of traditional Chinese medicine ingredients in the gel is enhanced to a great extent. Ethanol, glycerin and propylene glycol are added duringpreparation of the gel matrix, so that the gel matrix has certain solubility to podophyllotoxin, precipitation of podophyllotoxin is avoided when a podophyllotoxin ethanol solution is dropwise addedto the gel matrix for mixing, and the problem that podophyllotoxin is insoluble in hydrogel is solved. The podophyllotoxin-containing compound traditional Chinese medicine gel prepared by the method disclosed by the invention has the advantages of excellent properties, uniform components and stable gel quality. The gel disclosed by the invention contains podophyllotoxin and traditional Chinese medicine extract, so that the rapid curative effect of podophyllotoxin and the recurrence prevention effect of traditional Chinese medicines can be well combined. The gel can be used for treating condyloma acuminatum or preventing postoperative recurrence, can be used immediately after being applied, is convenient to use, can form a film quickly after being used, and avoids polluting clothes.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine gel, in particular to a compound traditional Chinese medicine gel containing podophyllotoxin and a preparation method thereof. Background technique [0002] Podophyllotoxin is the roots and roots of plants of the genus Peach Seven in the Berberidaceae genus Peach Seven, and Podophyllum plants such as Star Anise, Hexagon, Yunnan Star Anise, Tibet Star Anise, and Mountain Lotus. The lignan components extracted from the stem have significant anti-tumor, anti-virus, and anti-immune effects. [0003] The clinical application of podophyllotoxin mainly focuses on the treatment of genital warts. Podophyllotoxin can effectively inhibit herpes virus and mitosis in the middle stage of cells, and is used for viral sexually transmitted diseases. At present, in order to reduce the skin irritation of podophyllotoxin tincture and improve its shortcomings such as short action time, podophyllo...

Claims

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Application Information

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IPC IPC(8): A61K36/896A61K36/90A61K47/10A61K47/32A61P31/20A61K9/06A61K31/045A61K31/365A61K33/22
CPCA61K9/06A61K31/045A61K31/365A61K33/22A61K36/11A61K36/185A61K36/195A61K36/234A61K36/315A61K36/489A61K36/704A61K36/756A61K36/82A61K36/855A61K36/896A61K36/90A61K47/10A61K47/32A61P31/20A61K2300/00
Inventor 林福明
Owner 广西达庆生物科技有限公司
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