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Compound pharmaceutical composition containing benazepril and pimobendan for pets and preparation method of compound pharmaceutical composition

A technology of pimobendan and benazepril hydrochloride, which can be used in drug combinations, medical preparations containing active ingredients, active ingredients of heterocyclic compounds, etc., can solve problems such as exercise intolerance, fluid sensation, dyspnea, etc. , to achieve the effect of improving the survival rate, fast onset speed and high bioavailability

Active Publication Date: 2021-04-09
南京朗博特动物药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This can lead to exercise intolerance (inability to perform physical activity), difficulty breathing, and fluid sensation

Method used

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  • Compound pharmaceutical composition containing benazepril and pimobendan for pets and preparation method of compound pharmaceutical composition
  • Compound pharmaceutical composition containing benazepril and pimobendan for pets and preparation method of compound pharmaceutical composition
  • Compound pharmaceutical composition containing benazepril and pimobendan for pets and preparation method of compound pharmaceutical composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053]A compound double-layer tablet containing benazepril and pimobendan for pets, comprising the following raw materials in weight percentage: benazepril hydrochloride 1.0%, pimobendan 0.5%, diluent 70.5%, sustained-release matrix 3 %, coating taste-masking material 10%, disintegrant 3%, binder 2%, solubilizer 5%, glidant 1%, lubricant 2%, flavoring agent 1% and pigment 1%.

[0054] In the present embodiment, the prescription adopted by the benazepril pimobendan hydrochloride tablet for pets is as follows:

[0055]

[0056] In this prescription, hypromellose is selected as the slow-release matrix.

[0057] The solubilizer is selected from succinic acid.

[0058] Eudragit E100 was selected as the taste-masking material for the coating.

[0059] The diluent is microcrystalline cellulose.

[0060] The disintegrating agent is selected crospovidone.

[0061] Adhesive is selected povidone for use.

[0062] The flavoring agent is beef flavor essence.

[0063] The glidant i...

Embodiment 2

[0086]

[0087] The preparation method of the pharmaceutical composition in embodiment 2 is the same as embodiment 1.

Embodiment 3

[0089]

[0090] The preparation method of the pharmaceutical composition in embodiment 3 is the same as embodiment 1.

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PUM

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Abstract

The invention relates to the technical field of pharmaceutical compositions, in particular to a compound pharmaceutical composition containing benazepril and pimobendan for pets and a preparation method of the compound pharmaceutical composition. The pharmaceutical composition comprises the following active pharmaceutical ingredients in percentage by weight: 1%-8.0% of benazepril hydrochloride, 0.5%-4.0% of pimobendan, 42%-71% of diluent, 1%-5% of sustained-release skeleton, 10%-20% of coating taste masking material, 1.5%-4% of disintegrating agent, 1%-5% of adhesive, 5%-15% of solubilizer, 1%-5% of flow aid, 1%-3% of lubricant , 0.5%-2% of corrigent and a small amount of pigment. The compound composition prepared by the invention has the characteristics of convenience in administration, lasting effect and stable curative effect, can relax blood vessels and reduce blood pressure so as to reduce heart burden, and also can improve myocardial contractility and improve the survival rate of sick dogs; the medicine is high in effect taking speed and high in bioavailability; moreover, a taste masking coating process and a proper amount of meat flavor flavoring agent are added, so that it has a pleasant taste for pets and the medicine taking compliance of animals is greatly improved.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical compositions, in particular to a compound pharmaceutical composition containing benazepril and pimobendan for pets and a preparation method thereof. Background technique [0002] Benazepril Hydrochloride is a prodrug that is hydrolyzed in the liver to the active metabolite benazeprilat. The latter is an angiotensin-converting enzyme (ACE) inhibitor without a sulfhydryl group, which can inhibit the conversion of angiotensin Ⅰ to angiotensin Ⅱ, resulting in decreased vascular resistance, decreased aldosterone secretion, and plasma renin or renin activity. increased. It can also inhibit the degradation of bradykinin, reduce vascular resistance, and lower blood pressure. In heart failure, benazepril can dilate arteries and veins, reduce peripheral vascular resistance (afterload) and pulmonary capillary wedge pressure (preload), thereby improving cardiac output and improving exercise tolerance...

Claims

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Application Information

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IPC IPC(8): A61K9/24A61K31/501A61K31/55A61K47/32A61K47/38A61K47/12A61P9/04
CPCA61K9/209A61K9/2095A61K9/2027A61K9/2054A61K9/2013A61K31/501A61K31/55A61P9/04A61K2300/00
Inventor 刘利锋朱玉玲朱成强
Owner 南京朗博特动物药业有限公司
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