34 results about "Benazepril Hydrochloride" patented technology

The invention relates to a preparation method of a key intermediate of a medicine benazepril hydrochloride, that is, 3-[(1-(1S)-phenylethyl) amino]-2,3,4,5-tetrahydro-2-oxo-1H-(3S)-benzazepine. 3-bromo benzo caprolactam and (S)-1-phenylethylamine are used as raw materials; an object product is obtained by amination and a solvent-free configuration transformation reaction; the preparation method has low production cost and simple operations, and has industrial production value.

The invention discloses an amlodipine benazepril impulse tablet and a preparation method thereof. The amlodipine benazepril impulse tablet comprises a rapid-release tablet core and a controlled-release coating layer, wherein the rapid-release tablet core is prepared from a main drug and a tablet core auxiliary material, and the main drug is prepared from amlodipine besylate and benazepril hydrochloride. The preparation method comprises the following steps that (1) after the main drug and the tablet core auxiliary material are uniformly mixed, the rapid-release tablet core is prepared by adopting a direct powder compression method; (2) optionally, a swelling coating layer is formed on the rapid-release tablet core prepared in the step (1); and (3), the controlled-release coating layer is formed on the rapid-release tablet core prepared in the step (1) or the swelling coating layer prepared in the step (2) so as to obtain the amlodipine benazepril impulse tablet. According to the amlodipine benazepril impulse tablet and the preparation method thereof, the drug release time lag of the amlodipine benazepril impulse tablet can reach 1-10 h, the drug is completely and rapidly released, the drug release time lag accords with the pathogenetic time rule of hypertension and adverse reaction thereof, and the compliance of a patient is better; and in addition, a preparation process is simple, and relatively good industrial application values are achieved.

The invention relates to a preparation method of a key intermediate of a medicine benazepril hydrochloride, that is, 3-[(1-(1S)-phenylethyl) amino]-2,3,4,5-tetrahydro-2-oxo-1H-(3S)-benzazepine. 3-bromo benzo caprolactam and (S)-1-phenylethylamine are used as raw materials; an object product is obtained by amination and a solvent-free configuration transformation reaction; the preparation method has low production cost and simple operations, and has industrial production value.

The invention relates to an amlodipine and benazepril composition which is a tablet. The amlodipine benazepril tablet is obtained by treating amlodipine besylate and benazepril hydrochloride as active components, aerosil as a lubricant, lactose and microcrystalline cellulose as fillers and sodium carboxymethyl starch as a disintegrant and adopting a direct powder tabletting technology. The method has the advantages of simple process, and energy and time saving; and the prepared tablet has the advantages of stable quality, high dissolvability, and good disintegration.

The invention discloses a benazepril hydrochloride composition with effect of reducing blood pressure and a preparation method thereof. The preparation process comprises a solid fermentation method and a liquid fermentation method. Aspergillus CICC 2436 produces enzyme to hydrolyze benazepril hydrochloride, wherein the structure of part of benazepril hydrochloride is changed, namely an analog of benazepril hydrochloride. The original benazepril hydrochloride forms a composition containing the benazepril hydrochloride and the analog of the benazepril hydrochloride under the action of the enzyme, and the level of reducing the blood pressure by using the composition is superior to that of the benazepril hydrochloride with the same concentration.

The invention discloses an improved preparation method of benazepril hydrochloride and pharmaceutical composition containing the benazepril hydrochloride. With the adoption of the preparation method, the safety is high, the cost is low, the clean production value is high, industrial production is easy to realize, and meanwhile, the pharmaceutical composition is easy to prepare and use.

The present invention provides a kind of preparation method of benazepril hydrochloride tablet, by benazepril hydrochloride as the active ingredient of medicine, and pharmaceutical adjuvant filler, binding agent, disintegrant, lubricant magnesium stearate, The coating materials are combined into granules and made into tablets, which are characterized in that the lubricant magnesium stearate is added after the other components are granulated and coated, mixed and pressed into tablets. The invention can effectively physically separate the benazepril hydrochloride from the magnesium stearate, solves the problem that the related impurities of the variety rise too fast during storage, effectively controls the quality of the medicine, and has high use value.

The invention discloses an amlodipine / benazepril medicament composition liposome solid preparation and a preparation method thereof. The liposome is prepared by combining active components of benzenesulfonic acid amlodipine, benzepril hydrochloride and specific combination of phosphatidyl ethanolamine, dioleoyl phosphatidylglycerol, cholesterol and deoxysodium cholate, so that the stability, dissolution and bioavailability of the medicament are greatly improved, and the effect is stable and durable, and the curative effect is obvious. By utilizing the amlodipine / benazepril medicament composition liposome solid preparation, the quality of the product is improved, and the toxic and side effects are reduced.

The invention discloses an amlodipine / benazepril medicament composition liposome solid preparation and a preparation method thereof. The liposome is prepared by combining active components of benzenesulfonic acid amlodipine, benzepril hydrochloride and specific combination of phosphatidyl ethanolamine, dioleoyl phosphatidylglycerol, cholesterol and deoxysodium cholate, so that the stability, dissolution and bioavailability of the medicament are greatly improved, and the effect is stable and durable, and the curative effect is obvious. By utilizing the amlodipine / benazepril medicament composition liposome solid preparation, the quality of the product is improved, and the toxic and side effects are reduced.

A process for the preparation of benazepril hydrochloride (2) starting from the Michael adduct (14), obtained reacting compounds of formula (11) and (13), as defined in the disclosure

The invention discloses a benazepril hydrochloride composition with effect of reducing blood pressure and a preparation method thereof. The preparation process comprises a solid fermentation method and a liquid fermentation method. Aspergillus CICC 2436 produces enzyme to hydrolyze benazepril hydrochloride, wherein the structure of part of benazepril hydrochloride is changed, namely an analog of benazepril hydrochloride. The original benazepril hydrochloride forms a composition containing the benazepril hydrochloride and the analog of the benazepril hydrochloride under the action of the enzyme, and the level of reducing the blood pressure by using the composition is superior to that of the benazepril hydrochloride with the same concentration.

The invention relates to a preparation process of benazepril hydrochloride tablets which are traditional Chinese and western medicine composited preparations. The benazepril hydrochloride tablets are prepared from the following raw materials: 1 part of benazepril hydrochloride, 35 parts of curcuma aromatic, 35 parts of the root of red-rooted salvia, 35 parts of rhizoma corydalis, 30 parts of semen cassiae, 30 parts of the root of kudzu vine, 30 parts of burdock root, 25 parts of rhodiola rosea, 25 parts of honeysuckle, 25 parts of dandelion, 25 parts of uncaria rhynchophylla, 20 parts of ligusticum wallichii, 20 parts of polygala tenuifolia, 20 parts of eucommia ulmoides, 20 parts of cassia twig, 15 parts of hawthorn, 15 parts of liquorice, 15 parts of semen plantaginis, 10 parts of folium mori, 10 parts of the fruit of Chinese wolfberry, 8 parts of herba lycopi, 8 parts of root of common peony, 5 parts of the root of bidentate achyranthes, and 5 parts of peach kernel. The composition medicine can treat both symptoms and root causes of hypertension, is small in side effect, small in price, and simple and convenient to prepare, and has a wide application prospect.

The invention provides a traditional Chinese medicine for treating diabetic nephropathy and a preparation method thereof. The traditional Chinese medicine for treating diabetic nephropathy is prepared from the following traditional Chinese medicinal materials by weight: 6 to 15 parts of common fenugreek seed, 6 to 15 parts of milkvetch root, 3 to 8 parts of epimedium herb, 3 to 8 parts of malaytea scurfpea fruit, 3 to 8 parts of Asiatic cornelian cherry fruit, 1 to 5 parts of rhubarb root and rhizome, 3 to 8 parts of Chinese cassia tree and 2 to 6 parts of coptis. The invention further discloses the preparation method for the traditional Chinese medicine. According to the invention, renal tubulointerstitial fibrosis is dose-dependently inhibited through reduction of urine protein of rats with diabetic nephropathy, so a certain treatment effect is exerted on type 1 diabetic nephropathy and the treatment effect is equal to that of a benazepril hydrochloride tablet but better than that of a kidney-qi-tonifying pill. The traditional Chinese medicine also exerts a certain treatment effect on rats with type 2 diabetic nephropathy through approaches like protection of a kidney structure, reduction of the content of urine protein and improvement of in-vivo lipid metabolism disorder.