Benazepril hydrochloride-hyacinth oil nanoemulsion antihypertensive drug

Abstract

The invention discloses a benazepril hydrochloride-hyacinth oil nanoemulsion antihypertensive drug. Raw materials for the drug comprise, by mass percentage, 1% to 18% of benazepril hydrochloride, 15% to 40% of surfactant, 0 to 20% of cosurfactant and 1% to 20% hyacinth oil, with the balance being distilled water, wherein the sum of the mass percentage of the raw materials is 100%. Nanoemulsion provided in the invention has small and uniformly-distributed emulsion droplet particles, low viscosity and good fluidity. In the dosage form of nanoemulsion, the water-soluble drug benazepril hydrochloride and fat-soluble hyacinth oil are organically combined together, which improves the solubility and permeability of hyacinth oil and the stability and efficacy of benazepril hydrochloride. When the dosage form of nanoemulsion is prepared from benazepril hydrochloride and hyacinth oil, the advantages of both benazepril hydrochloride and hyacinth oil are combined; therefore, an antihypertensive effect of the drug provided in the invention is obviously improved, the half-life of the drug is prolonged, and administration frequency is reduced.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to a new dosage form of an antihypertensive drug benazepril hydrochloride and hyacinth oil, in particular to a nanoemulsion antihypertensive drug of benazepril hydrochloride and hyacinth oil. [0002] Background technique [0002] Benazepril HCL. CAS number: 86541-74-4. Molecular formula: C 24 h 29 ClN 2 o 5 , molecular weight: 460.95. Benazepril hydrochloride is an angiotensin converting enzyme inhibitor. After hydrolysis, it forms benazeprilat with strong vitality, which becomes a competitive angiotensin-converting enzyme inhibitor, prevents angiotensin I from being converted into angiotensin II, reduces vascular resistance, reduces aldosterone secretion, and plasma renin Increased activity, but does not cause compensatory fluid retention, can also reduce ventricular afterload, without increasing heart rate. Benazeprilat also reduces cardiac load: this product expands arteries an...

AI Technical Summary

Problems solved by technology

There are antihypertensive drugs such as benazepril hydrochloride tablets on the market now, and the use of hyacinth oil is also available. Although it can be absorbed from the gastrointestinal tract after oral administration, the absorption is not complete. In addition, the dissolution rate of the drug is slow and the bioavailability is poor. , coupled with the slow action of benazepril hydrochloride, the efficacy of benazepril hydrochloride and hyacinth oil cannot be fully utilized