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Benazepril hydrochloride soft chewable tablet and preparation method thereof

A technology of benazepril hydrochloride and soft chewable tablets, which is applied in the fields of pharmaceutical formula, pill delivery, cardiovascular system diseases, etc. It can solve the problems of the stability of the main drug components, disintegration, and increased difficulty in dissolution, so as to improve the palatability performance, improving stability

Active Publication Date: 2016-09-28
QILU ANIMAL HEALTH PROD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this makes the disintegration and dissolution of the tablet more difficult
[0007] In addition, most of the flavoring agents added in the prior art generally have a great impact on the stability of the main ingredients. Therefore, it is also very important to solve the stability problem of soft chewable tablets

Method used

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  • Benazepril hydrochloride soft chewable tablet and preparation method thereof
  • Benazepril hydrochloride soft chewable tablet and preparation method thereof
  • Benazepril hydrochloride soft chewable tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] A soft chewable tablet of benazepril hydrochloride, calculated by weight percentage, the content of each component is as follows:

[0052]

[0053] The preparation method of benazepril hydrochloride soft chewable tablet: make benazepril hydrochloride utilize EPO is fluidized bed coated, the coating weight is increased by 5%, sieved through 40 mesh and 65 mesh, and the coated granules are obtained by removing coarse particles and uncoated fine powder; the coated granules are mixed with hydrogenated vegetable oil and soybean protein , cross-linked povidone, and artificial beef flavor are pre-mixed; then propyl p-hydroxybenzoate and propylene glycol are added for total mixing, mixed evenly and then extruded.

Embodiment 2

[0055] A soft chewable tablet of benazepril hydrochloride, calculated by weight percentage, the content of each component is as follows:

[0056]

[0057]

[0058] Preparation method: use benazepril hydrochloride EPO is used for fluidized bed coating, and the weight gain of the coating is 4%, and the granules are sieved through 40 mesh and 65 mesh, and the coarse particles and uncoated fine powder are removed to obtain the coated granules; the coated granules are mixed with hydrogenated vegetable oil and soybean protein Cross-linked povidone and artificial beef flavor are premixed; then propyl p-hydroxybenzoate and propylene glycol are added for total mixing, mixed evenly and then extruded.

Embodiment 3

[0060] A soft chewable tablet of benazepril hydrochloride, calculated by weight percentage, the content of each component is as follows:

[0061]

[0062] Preparation method: use benazepril hydrochloride EPO is fluidized bed coated, and the weight of the coating is increased by 5%; the granules are sieved through 40 mesh and 65 mesh, and the coarse particles and uncoated fine powder are removed to obtain the coated granules; the coated granules are mixed with hydrogenated vegetable oil and soybean protein Cross-linked povidone and artificial beef flavor are premixed; then propyl p-hydroxybenzoate and propylene glycol are added for total mixing, mixed evenly and then extruded.

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Abstract

A benazepril hydrochloride soft chewable tablet is prepared from, by weight, 1-5% of benazepril hydrochloride, 2-15% of hydrophobic excipient, 20-60% of a filling agent, 2-10% of a disintegrant, 10-40% of a corrigent, 0.2-1% of a preservative, 2-10% of a wetting agent and 0.01-0.3% of a coating material. Benazepril hydrochloride is used as an active ingredient of the chewable tablet, coated and then mixed with the hydrophobic excipient, the filling agent, the disintegrant and the corrigent, the preservative and the wetting agent are added, mixing is performed well, and a mixture is extruded. The benazepril hydrochloride soft chewable tablet is high in palatability and little in irritation to stomach and intestines when being taken, can quickly disintegrate and is quick in dissolution of the active ingredient and stable in quality.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a benazepril hydrochloride soft chewable tablet and a preparation method thereof. Background technique: [0002] After dogs and cats enter old age at the age of 10, various organs of the body will also age and even develop lesions. Heart disease is one of the most important and common senile diseases in dogs and cats, and it should be put in the first place. [0003] For animals with heart disease, the palatability of therapeutic drugs is very critical, because it is not possible to force-feed drugs to increase the stress on animals, and in addition, animals’ poor compliance with drugs will directly affect the therapeutic effect of drugs and cannot improve the treatment effect of patients. The quality of life of sick animals, that is, treatment failure! [0004] Benazepril hydrochloride, used in the treatment of hypertension and congestive heart failure. An angiotensi...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/55A61P9/12A61P9/06A61K9/16
CPCA61K9/0056A61K9/2031A61K9/2095A61K9/5026A61K31/55
Inventor 梁秀婷王海挺孟双双韩文王甜孔梅吴连勇
Owner QILU ANIMAL HEALTH PROD
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