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Benazepril hydrochloride chewable tablet for pet and preparation method of benazepril hydrochloride chewable tablet

A technology of benazepril hydrochloride and chewable tablets, which is applied in the field of pet benazepril hydrochloride chewable tablets and its preparation, can solve the problems of increased difficulty in disintegration and dissolution, and solve the problems of difficult disintegration and dissolution, combination Reasonable portion ratio and the effect of improving compliance

Inactive Publication Date: 2018-12-11
河北远征药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this makes the disintegration and dissolution of the tablet more difficult

Method used

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  • Benazepril hydrochloride chewable tablet for pet and preparation method of benazepril hydrochloride chewable tablet
  • Benazepril hydrochloride chewable tablet for pet and preparation method of benazepril hydrochloride chewable tablet
  • Benazepril hydrochloride chewable tablet for pet and preparation method of benazepril hydrochloride chewable tablet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] A pet benazepril hydrochloride chewable tablet, comprising the following raw materials in weight percentage: benazepril hydrochloride 2.5%, binding agent 2%, diluent 56%, disintegrant 1.75%, glidant 2.5%, 15% flavoring agent, 20.25% coating taste-masking material.

[0040] In the present embodiment, the prescription adopted for the pet benazepril hydrochloride chewable tablet is the following table:

[0041]

[0042] In this prescription, the disintegrating agent is crospovidone.

[0043] The adhesive is hypromellose.

[0044] The flavoring agent is selected from yeast extract and beef powder seasoning.

[0045] Glidant selects talcum powder for use.

[0046] The diluent is microcrystalline cellulose.

[0047] Taste-masking materials for coating include blank core pellets, Eudragit E100 and talcum powder.

[0048] see figure 1 The preparation flowchart, the preparation method of benazepril hydrochloride chewable tablet for pets, comprises the following steps: ...

Embodiment 2

[0082] A pet benazepril hydrochloride chewable tablet, comprising the following raw materials in weight percentage: benazepril hydrochloride 5.715%, binder 4.57%, diluent 30.058%, disintegrant 1.714%, glidant 2.514%, The flavoring agent is 9.142%, and the coating taste-masking material is 46.287%.

[0083] The prescription that embodiment 2 adopts is the following table:

[0084]

[0085] In this prescription, the disintegrating agent is crospovidone.

[0086] The adhesive is hypromellose.

[0087] The flavoring agent is selected from yeast extract and beef powder seasoning.

[0088] Glidant selects talcum powder for use.

[0089] The diluent is microcrystalline cellulose.

[0090] Coating taste-masking materials include blank core pellets (coating matrix), Eudragit E100 and talcum powder (coating solution).

[0091] see figure 1 The preparation flowchart, the preparation method of benazepril hydrochloride chewable tablet for pets, comprises the following steps:

[0...

Embodiment 3

[0124] A kind of benazepril hydrochloride medicine tablet for pet, comprises following raw material in percentage by weight: benazepril hydrochloride 2%, hypromellose 2%, microcrystalline cellulose 50%, crospovidone 1.5% , talcum powder 6.5%, yeast extract and beef powder seasoning 16%, coating taste-masking material 22% (including blank core balls, Eudragit E100 and talcum powder). Among them, the ratio of blank core pellets, Eudragit E100 and talcum powder is about 64:8:9.

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Abstract

The invention relates to a benazepril hydrochloride chewable tablet for a pet. The benazepril hydrochloride chewable tablet for the pet is prepared from the following raw materials in percentage by weight: 2.0-6.0 percent of benazepril hydrochloride, 2-5 percent of an adhesive, 30-60 percent of a diluent, 1.5-2.5 percent of a disintegrant, 2.5-6.5 percent of a glidant, 9-16 percent of a corrigentand 20-47 percent of coating smell masking material. The chewable tablet provided by the invention can mask smell without influencing dissolution. A benazepril hydrochloride drug composition preparedwith the method keeps all effective components of the raw materials, greatly improves the compliance after being orally taken by adding the diluent and an embedding skeleton and reaches better maintenance effect without generating larger stimulation to gastrointestinal tract.

Description

technical field [0001] The invention belongs to the technical field of veterinary pharmacy, and in particular relates to a benazepril hydrochloride chewable tablet for pets and a preparation method thereof. The benazepril hydrochloride chewable tablet for pets can mask the smell without affecting the dissolution, and can be easily taken orally by animals. Background technique [0002] Benazepril Hydrochloride (Benazepril Hydrochloride, C 24 h 28 N 2 o 5 ﹒ HCl) is an angiotensin-converting enzyme inhibitor, mainly used in animal husbandry and pet breeding. At present, benazepril hydrochloride has been widely used in the treatment of hypertension and congestive heart failure at home and abroad. Benazepril hydrochloride, as the second-generation non-sulfhydryl angiotensin-converting enzyme inhibitor, is a drug with better clinical efficacy, high safety and less adverse reactions among the current international ACEI drugs. It is different from other drugs for the treatment...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K9/50A61K47/38A61K47/32A61K47/02A61K31/55A61P9/04A61P13/12A61P9/00
CPCA61K9/0056A61K9/2027A61K9/2054A61K9/2081A61K9/501A61K9/5047A61K9/5073A61K31/55A61P9/00A61P9/04A61P13/12
Inventor 廖洪
Owner 河北远征药业有限公司
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