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Oroxylin A pharmaceutical composition and application thereof in preparation of liver cancer drugs

A technology of melaleuca paper element and composition, applied in the field of medicine, can solve the problems of inapplicability to oral preparations, complicated process, unfavorable large-scale production, etc., and achieve the effect of improving bioavailability

Inactive Publication Date: 2021-04-20
南京芩领医药科技有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Common methods to increase drug solubility and drug dissolution include salt formation, solubilization, and solid dispersion techniques, but techniques such as salt formation and solid dispersion are generally complicated in the production process, which is not conducive to large-scale production; and surfactants Solubilization is mostly used for liquid preparations, not for oral preparations

Method used

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  • Oroxylin A pharmaceutical composition and application thereof in preparation of liver cancer drugs
  • Oroxylin A pharmaceutical composition and application thereof in preparation of liver cancer drugs
  • Oroxylin A pharmaceutical composition and application thereof in preparation of liver cancer drugs

Examples

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Embodiment 1

[0017] In this embodiment, jet milling is used to micronize the kelplin. The particle size of the kelplin raw material before micronization is 44 μm, and the particle size of the kelplinin after micronization is 4.4 μm. The particle size test results are as follows figure 1 , figure 2 shown.

[0018] The inhibitory effect of the above-mentioned kelpifene raw material and micropowder on the tumor growth of the PDX model of human liver cancer was studied. details as follows:

[0019] 1. Test drugs

[0020] Disperse the raw material and micropowder of phyllophyllin in 0.5% CMC-Na respectively, the concentration of the prepared drug is 15mg / ml, and the administration volume is 0.4ml / 20g, that is, the administration concentration is 300mg / kg.

[0021] 2. Positive control drugs

[0022] Sorafenib (Bayer pharmaceutical industry, specification: 200mg / sheet), tablet is ground into powder, takes by weighing 12.74mg drug powder (medicine content 56.51%), shakes evenly with 1.2mlCM...

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Abstract

The invention discloses an oroxylin A pharmaceutical composition and application thereof in preparation of liver cancer drugs, and belongs to the technical field of medicines. The particle size of oroxylin A in the pharmaceutical composition is 1-10 microns, and oroxylin A can be prepared into granules, tablets, capsules, pills, oral solutions, oral suspensions or oral emulsions and used for preparing liver cancer treatment drugs. According to the composition, the oroxylin A is micronized by utilizing airflow crushing, so that the bioavailability of the oroxylin A can be remarkably improved.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to a kelp paper composition and its application in the preparation of liver cancer medicines. Background technique [0002] Oroxylin A, one of the active components of Scutellaria baicalensis, has significant antitumor effects and is a natural antitumor drug with broad application prospects. However, the pharmacological effects of kelciene are extensive, and the mechanism of its anti-tumor effect has not yet been fully elucidated. The literature shows that celestein can exert its anti-tumor effect by inducing tumor cell apoptosis, and also has the effect of inhibiting the growth of tumor blood vessels. At the same time, the anti-cancer effect of celesteol is different from that of general chemotherapy and anti-cancer drugs. It can selectively kill tumor cells and has little effect on the normal hematopoietic system, which is not available in current tumor chemotherapy ...

Claims

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Application Information

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IPC IPC(8): A61K9/14A61K31/352A61P35/00
Inventor 柯学郭青龙王雅蒙
Owner 南京芩领医药科技有限公司
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