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Particle analysis method and apparatus for a spectrometry-based particle analysis

A technology of particle analysis and spectrometry, which is applied in the fields of biology, medicine and biochemistry, and can solve problems such as expensive, complex geometric structures, etc.

Pending Publication Date: 2021-04-23
MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN EV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Second, in addition to reducing the information content of the measurement, if the technique of Ref. [1] is used to detect multiple spectral elements, a large number of quantum cascade lasers and the same number of detectors are required, resulting in expensive and geometrically Complex and huge

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  • Particle analysis method and apparatus for a spectrometry-based particle analysis
  • Particle analysis method and apparatus for a spectrometry-based particle analysis
  • Particle analysis method and apparatus for a spectrometry-based particle analysis

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Embodiment Construction

[0071] A key aspect of the invention lies in the ability to broadband, temporally and / or spectrally resolve optical Measurement. This enables the following four advantageous features of the invention, which are described in further detail below:

[0072] 1. Broadband (for example, from 1000-3000cm -1 or other ranges as mentioned above) sample beam, allowing fast measurements with sufficient signal-to-noise ratio, especially for high-throughput performance;

[0073] 2. Methods and apparatus that can introduce and achieve a rapid and controlled change in relative phase delay between a sample beam and a probe beam (in particular, the probe beam can be a portion / copy of the output of the laser source that produced the sample beam, or be a beam generated by a second laser system coupled to the laser source that generates the sample beam);

[0074] 3. Fast and sensitive light detection schemes, especially utilizing fast readout electronics and data processing;

[0075] 4. The li...

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Abstract

A particle analysis method and apparatus, including a spectrometry- based analysis of a fluid sample (1), comprises the steps of creating a sample light beam S and a probe light beam P with a light source device (10) and periodically varying a relative phase between the sample and probe light beams S, P with a phase modulator device (20), irradiating the fluid sample (1) with the sample light beam S, detecting the sample and probe light beams S, P with a detector device (40), and providing a spectral response of the at least one particle (3), wherein the light source device (10) comprises at least one broadband source, which has an emission spectrum covering a mid-infrared MIR frequency range, and the phase modulator device (20) varies the relative phase with a scanning period equal to or below the irradiation period of irradiating the at least one particle (3, 4).

Description

technical field [0001] The present invention relates to a particle analysis method comprising spectrometry-based analysis of a flowing fluid sample having at least one particle to be analyzed, in particular at least one biological particle such as a biological cell or a component thereof. In particular, the invention relates to a method of particle analysis that allows providing diagnostically relevant information. Furthermore, the invention relates to a particle analysis device for spectrometry-based analysis of a flowing fluid sample having at least one particle. The invention can be applied in the fields of biology, medicine (especially medical diagnostics and therapy) and biochemistry (especially fast infrared spectroscopy for flow cytometry). The particle analysis device can be used as a particle sorting and / or detection device, in particular as a cell sorting and / or detection device. Background technique [0002] This specification describes the background technology...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N15/14G01N15/10
CPCG01N15/1429G01N15/1434G01N15/1459G01N2015/1006G01N2015/1454G01N33/4833G01N2015/0065
Inventor 费伦茨·克劳斯约阿希姆·普佩扎M·齐尔曼科尔迈尔M·胡贝尔
Owner MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN EV