Preparation method of PEG/PEI-modified magnetic nanoparticles

A magnetic nanoparticle and iron particle technology, applied in the field of biomedicine, can solve the problems of endoplasmic reticulum phagocytosis, insufficient active targeting of the carrier system, and difficult tumor tissue localization and retention.
CN112791194APending Publication Date: 2021-05-14XIN HUA HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE +1
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
XIN HUA HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
Publication Date
2021-05-14

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Abstract

The invention provides a preparation method of magnetic nanoparticles. The preparation method is characterized by comprising the following steps: S1, adding alcohol into vortex iron particles, and dispersing the vortex iron particles via ultrasonic treatment; S2, carrying out magnetic adsorption separation to remove alcohol; S3, adding PEG and / or PEI and water, and performing ultrasonic emulsification; and S4, discarding a supernatant, conducting washing with water and alcohol respectively, collecting a precipitate, and drying the precipitate to obtain the PEG and / or PEI modified magnetic nanoparticles. The obtained nano-carrier is low in toxicity and good in effect.
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Description

technical field

[0001] The invention relates to the field of biomedicine, in particular to a nanocarrier, and more specifically to a preparation method and application of PEG / PEI-modified magnetic nanoparticles. Background technique

[0002] Magnetic nanoparticles, due to the nano-size effect, exhibit physical and chemical properties that are completely different from those of macroscopic magnetic materials, such as: large specific surface area, superparamagnetic properties, and diverse topological magnetic structures, etc. It can be assembled and positioned under a constant magnetic field, making it widely used in biomedical fields such as targeted drug carriers and magnetically controlled drug release, absorbing electromagnetic waves under an alternating magnetic field to generate heat for tumor hyperthermia.

[0003] In the prior art, liver cancer-specific therapeutic genes are constructed by using liver cancer-specific promoters and hypoxia-responsive sequences to guide ...

Claims

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