Arctiin compound entrapped local skin external preparation based on solid particle emulsification technology and preparation method and application of arctiin compound entrapped local skin external preparation

Abstract

The embodiment of the invention relates to the field of preparations, in particular to an arctiin compound entrapped local skin external preparation based on a solid particle emulsification technology and a preparation method and application of the arctiin compound entrapped local skin external preparation. The arctiin compound entrapped external preparation provided by the embodiment of the invention comprises the following components in parts by weight: 1-15 parts of arctiin or arctigenin, 0.5-10 parts of a solid particle emulsifier, 10-40 parts of an oil phase, 5-30 parts of a solubilizer and 1-10 parts of a thickening agent, wherein the particle size of the solid particle emulsifier is nanometer or micrometer. According to the arctiin compound entrapped external preparation provided by the embodiment of the invention, the arctiin compound forms a stable and efficient system through the solid particle emulsifier, and can stably release medicine in the medication process. In addition, compared with a traditional emulsion, the external preparation also enhances the skin permeability and retention property of the arctiin compound, and shows better pharmacological activity and curative effect.

Description

technical field

[0001] The invention relates to the field of preparations, in particular to a topical skin external preparation loaded with arctiin compounds based on solid particle emulsification technology and its preparation method and application. Background technique

[0002] Emulsions are one of the main dosage forms for topical therapy, with the advantage of protecting the encapsulated drug while increasing its solubility and improving drug skin penetration behavior. Since the emulsion is a thermodynamically unstable system, it is necessary to use a stabilizer to form a stable system and ensure its long-term stability. To date, most emulsions have relied on synthetic surfactants for stabilization. More and more studies have shown that the application of surfactants will lead to skin safety problems, while their role in stabilizing the emulsion system is not strong and the cost is high.

[0003] In addition, the traditional emulsion process is relatively complicated,...

Examples

Embodiment 1

[0083] 1. an external preparation matrix of arctiin compounds, comprising:

[0084] 244FP 1.5g, diethylene glycol monoethyl ether 11.5g, hydroxypropyl cellulose 2g, light liquid paraffin 25g, water 60g.

[0085] The preparation method of above-mentioned external preparation matrix comprises the following steps:

[0086] Add water and hydroxypropyl cellulose to diethylene glycol monoethyl ether to fully swell to obtain an aqueous phase; Disperse 244FP in light liquid paraffin to obtain an oil phase; add the oil phase to the water phase and homogenize at a speed of 15,000 rpm for 5 minutes to obtain the product.

[0087] 2. An external preparation of arctiin compounds, comprising:

[0088] Arctigenin 5g, 244FP 1.5g, diethylene glycol monoethyl ether 11.5g, hydroxypropyl cellulose 2g, light liquid paraffin 25g, water 60g.

[0089] The preparation method of above-mentioned external preparation comprises the steps:

[0090] Dissolving arctigenin in the prescription amount ...

Embodiment 2

[0092] An external preparation of arctiin compounds, comprising:

[0093] Arctiin 5g, 244FP 1.5g, diethylene glycol monoethyl ether 11.5g, hydroxypropyl cellulose 2g, light liquid paraffin 25g, water 60g.

[0094] The preparation method of above-mentioned external preparation comprises the steps:

[0095] Disperse the arctiin of the prescribed amount in diethylene glycol monoethyl ether, add water and hydroxypropyl cellulose, fully swell, and obtain the water phase; Disperse 244FP in light liquid paraffin to obtain an oil phase; add the oil phase to the water phase and homogenize at a speed of 15,000 rpm for 5 minutes to obtain the product.

Embodiment 3

[0097] An external preparation of arctiin compounds, comprising:

[0098] Arctigenin 2.5g, MCG 591P 5g, propylene glycol 20g, povidone K30 5g, simethicone 10g, water 57.5g.

[0099] The preparation method of above-mentioned external preparation comprises the steps:

[0100] Dissolve the prescribed amount of arctigenin in propylene glycol, add water and povidone K30, fully dissolve, and then add MCG 591P is uniformly dispersed to obtain a water phase; add simethicone as an oil phase to the water phase, and homogenize at a speed of 7000rpm for 20 minutes to obtain the product.

technical field

[0001] The invention relates to the field of preparations, in particular to a topical skin external preparation loaded with arctiin compounds based on solid particle emulsification technology and its preparation method and application. Background technique

[0002] Emulsions are one of the main dosage forms for topical therapy, with the advantage of protecting the encapsulated drug while increasing its solubility and improving drug skin penetration behavior. Since the emulsion is a thermodynamically unstable system, it is necessary to use a stabilizer to form a stable system and ensure its long-term stability. To date, most emulsions have relied on synthetic surfactants for stabilization. More and more studies have shown that the application of surfactants will lead to skin safety problems, while their role in stabilizing the emulsion system is not strong and the cost is high.

[0003] In addition, the traditional emulsion process is relatively complicated,...

Examples

Embodiment 1

[0083] 1. an external preparation matrix of arctiin compounds, comprising:

[0084] 244FP 1.5g, diethylene glycol monoethyl ether 11.5g, hydroxypropyl cellulose 2g, light liquid paraffin 25g, water 60g.

[0085] The preparation method of above-mentioned external preparation matrix comprises the following steps:

[0086] Add water and hydroxypropyl cellulose to diethylene glycol monoethyl ether to fully swell to obtain an aqueous phase; Disperse 244FP in light liquid paraffin to obtain an oil phase; add the oil phase to the water phase and homogenize at a speed of 15,000 rpm for 5 minutes to obtain the product.

[0087] 2. An external preparation of arctiin compounds, comprising:

[0088] Arctigenin 5g, 244FP 1.5g, diethylene glycol monoethyl ether 11.5g, hydroxypropyl cellulose 2g, light liquid paraffin 25g, water 60g.

[0089] The preparation method of above-mentioned external preparation comprises the steps:

[0090] Dissolving arctigenin in the prescription amount ...

Embodiment 2

[0092] An external preparation of arctiin compounds, comprising:

[0093] Arctiin 5g, 244FP 1.5g, diethylene glycol monoethyl ether 11.5g, hydroxypropyl cellulose 2g, light liquid paraffin 25g, water 60g.

[0094] The preparation method of above-mentioned external preparation comprises the steps:

[0095] Disperse the arctiin of the prescribed amount in diethylene glycol monoethyl ether, add water and hydroxypropyl cellulose, fully swell, and obtain the water phase; Disperse 244FP in light liquid paraffin to obtain an oil phase; add the oil phase to the water phase and homogenize at a speed of 15,000 rpm for 5 minutes to obtain the product.

Embodiment 3

[0097] An external preparation of arctiin compounds, comprising:

[0098] Arctigenin 2.5g, MCG 591P 5g, propylene glycol 20g, povidone K30 5g, simethicone 10g, water 57.5g.

[0099] The preparation method of above-mentioned external preparation comprises the steps:

[0100] Dissolve the prescribed amount of arctigenin in propylene glycol, add water and povidone K30, fully dissolve, and then add MCG 591P is uniformly dispersed to obtain a water phase; add simethicone as an oil phase to the water phase, and homogenize at a speed of 7000rpm for 20 minutes to obtain the product.

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