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Application of Kauri Extract in Preparation of Products Against Nonalcoholic Fatty Liver
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A non-alcoholic, extractive technology, applied in the field of medicine, achieves the effects of drug safety, easy popularization and application, and rich source of raw materials
Active Publication Date: 2022-06-28
PEKING UNIV
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[0004] There are no reports on the effects of Kauri and its monomer components on NAFLD
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Embodiment 1
[0047] Example 1. Preparation of Kauri extract (AD) and its monomers
[0048] 1. Preparation of Kauri Extract
[0049] The dried and crushed Kauri root powder (367g) was put into a 3.0L round-bottomed flask, and 2.5L of 95% ethanol was added to soak for 1 hour, then heated to a slightly boiling state, heated and refluxed for extraction for 2 hours, and the extract was filtered while hot. The medicinal residues were then extracted with 2.0 L of 95% ethanol and heated under reflux for 2 times, 1.5 h each time. The filtrates were combined, concentrated by a rotary evaporator, vacuum-dried, and weighed to obtain 105.3 g of Kauri extract (extraction rate: 28.7%).
[0050] 2. Preparation of monomers
[0051] Take the Kauri extract (100.0 g) prepared above, add 1.0 L of water to suspend, extract with dichloromethane, and extract 3 times with 1.0 L of extractant each time, combine the extracts to obtain the dichloromethane layer extraction material 34.0g.
[0052] The dichlorometh...
Embodiment 2
[0064] Example 2. Pharmacodynamic test of Kauri extract and its monomers
[0065] 1. Experimental materials
[0066] 1.1 Experimental animals
[0067] The mice used in the experiment were male C57BL / 6 mice with an average body weight of 20-25 g, purchased from Peking University Medical Center - Laboratory Animal Center, following the principles of laboratory animal care (NIH Publication No. 85-23, revised edition 1996), and the experimental protocol Approved by the Animal Ethics Committee of Peking University School of Medicine: All mice were housed under a 12-h light / 12-h dark cycle with free access to food and water.
[0068] 1.2 Animal Feed
[0069] Animal breeding feeds are commercial rodent feeds, including ordinary feeds, methionine choline-deficient feeds and high-fat feeds.
[0070] 2. In vivo experimental method
[0071] 2.1 Establishment of MCD diet-induced non-alcoholic fatty liver model
[0072] 8-week-old male C57BL / 6 mice were fed with MCD diet for 7 consecu...
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Abstract
The invention discloses a new medicine application of a kauri extract (Agathis dammara, AD). The new application is the application of the kauri extract in the preparation of anti-nonalcoholic fatty liver disease (NAFLD) products. The present invention uses two clinically relevant NAFLD models: methionine-choline-deficient diet (MCD diet) and high-fat diet (HFD)-induced C57BL / 6 mice with non-alcoholic fatty liver disease. Experiments have shown that oral gavage of Kauri extract can significantly inhibit the occurrence and development of non-alcoholic fatty liver in mice induced by MCD diet and high-fat diet, and can be used for the prevention and treatment of non-alcoholic fatty liver.
Description
technical field [0001] The invention belongs to the field of medicine, in particular to the application of kauri extract in the preparation of anti-alcoholic fatty liver products. Background technique [0002] Kauri (Latin name Agathis dammara) tree belongs to Gymnosperm phylum taxonomically, Conifer class, Conifer order, Araucaceae, Kauri genus, mainly distributed in tropical Asia, introduced and cultivated in Xiamen, Fuzhou and other places in my country. The volatile oil in its leaves mainly contains terpenoids, of which β-solanone is the main component, and also contains alkanes, alcohols, ketones and a small amount of aldehydes, ethers and esters and other compounds. It has important uses and is of great significance in phytochemical taxonomy. The pharmacological effects of Kauri can be roughly divided into the following aspects: anti-tumor; antibacterial; anti-inflammatory; sedative; [0003] Non-alcoholic fatty liver disease (NAFLD) refers to a clinicopathological s...
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