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Polysaccharide-based tissue bonding medical adhesive and application thereof

一种多糖、组织的技术，应用在应用、医药科学、外科黏合剂等方向，能够解决多孔和粗糙表面填隙性能差、体内降解时间快、抗冲击性能差等问题，达到良好生物安全性、快组织粘合时间、强度低的效果

Active Publication Date: 2021-06-15
WENDE XILIN (HANGZHOU) BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the defects of poor impact resistance, low viscosity, poor interstitial performance to porous and rough surfaces, fast degradation time in vivo, no heat resistance, and poor water resistance, this adhesive has been restricted in its application in medicine to a certain extent. limitations

Method used

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  • Polysaccharide-based tissue bonding medical adhesive and application thereof
  • Polysaccharide-based tissue bonding medical adhesive and application thereof
  • Polysaccharide-based tissue bonding medical adhesive and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] The preparation of polysaccharide-based tissue-adhesive medical glue: the dextran (structural formula is: wherein m=5-2000, n=1-1800, degree of substitution 90%) and 0.5 g of branched polyethyleneimine are dissolved in 50 mL of deionized water, and stirred for 6 hours. After routine purification, drying, and grinding, the powdered polysaccharide-based tissue-adhesive medical glue 1 is obtained,

Embodiment 2

[0030] Preparation of polysaccharide-based tissue adhesive medical glue: 2g oxidized sodium alginate powder (structural formula is: wherein m=20-1000, n=1-900, degree of substitution 70%) mixed with 0.8 g of dopamine hydrochloride powder to obtain powdery polysaccharide-based tissue-adhesive medical glue 2.

Embodiment 3

[0032] The preparation of polysaccharide-based tissue-adhesive medical glue: the pullulan (structural formula is:

[0033] wherein m=15-4000, n=1-3600, substitution degree 5%) and 0.6 g of α-cyclodextrin were dissolved in 60 mL of deionized water, and stirred for 3 hours. After routine purification, drying, and grinding, the powdery polysaccharide-based tissue-adhesive medical glue 3 was obtained.

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PUM

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Abstract

The invention discloses a polysaccharide-based tissue bonding medical adhesive and application thereof. The polysaccharide-based tissue bonding medical adhesive is prepared from a polysaccharide derivative and a compound with at least two reaction functional groups, wherein the polysaccharide derivative and the compound with at least two reaction functional groups generate a bonding effect through one or more of physical action or chemical reaction; and the polysaccharide derivative is polysaccharide substituted by functional groups. The polysaccharide-based tissue bonding medical adhesive can bear larger tension; compared with a cyanoacrylate medical adhesive, the polysaccharide-based tissue bonding medical adhesive has the advantages of shorter tissue bonding time and higher tissue stripping force, and can realize quick bonding and sealing of wounds; and meanwhile, after application, the polysaccharide-based tissue bonding medical adhesive has strong adhesive force with tissues, is not easy to strip, can be suitable for stretched wounds, and can realize effective closing.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and relates to polysaccharide-based tissue bonding medical glue and its application. Background technique [0002] Medical glue refers to the preparation, material or substance that can adhere to the surface or cause adhesion between surfaces in medical applications, mainly used for local adhesion and repair of organs or tissues, replacing traditional sutures; or tissues, blood vessels The combination and positioning of plugging and other technical fields. Compared with traditional methods such as suturing and stapling, the use of medical glue can effectively shorten the operation time and significantly reduce the patient's pain. In tissue bonding, bonding generally involves the following aspects: 1. The adhesion between the internal activities of living tissue; 2. The adhesion between the organism and the medical glue; 3. The adhesion between the medical glue of adhesion. An important part...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/04A61L24/00
CPCA61L24/001A61L24/043C08L5/08C08L5/04C08L5/12C08L3/02C08L1/02C08L5/00C08L5/02C08L5/16
Inventor 徐福建李杨
Owner WENDE XILIN (HANGZHOU) BIOTECHNOLOGY CO LTD
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