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Application of MT-ND6 as new target in metabolic syndrome diagnosis and treatment drugs

A MT-ND6, 1. MT-ND6 technology is applied in the fields of biology and medicine, achieving good application prospects, important development value, and easy operation

Active Publication Date: 2021-06-18
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report on whether the MT-ND6 gene can regulate the occurrence of metabolic diseases such as obesity, diabetes, and hyperlipidemia.

Method used

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  • Application of MT-ND6 as new target in metabolic syndrome diagnosis and treatment drugs
  • Application of MT-ND6 as new target in metabolic syndrome diagnosis and treatment drugs
  • Application of MT-ND6 as new target in metabolic syndrome diagnosis and treatment drugs

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] The methylation of MT-ND6 gene can be used as a biomarker for early clinical screening, diagnosis and prognosis of insulin resistance-based metabolic syndrome such as obesity, type 2 diabetes and its complications

[0051] Such as figure 1 As shown in A and C, the methylation level of MT-ND6 gene was significantly increased in the peripheral blood leukocytes of type 2 diabetics and the liver of obese mice. Such as figure 2 As shown in C and D, linear correlation analysis showed that the methylation level of MT-ND6 gene in human peripheral blood leukocytes was positively correlated with the content of HOMA-IR and glycosylated hemoglobin, suggesting that methylation of MT-ND6 could be used as a biomarker of insulin resistance thing. Since insulin resistance is the pathological basis and core link of many metabolic diseases such as obesity and type 2 diabetes, the methylation of MT-ND6 gene can be used as an early clinical screening for metabolic syndrome and its compli...

Embodiment 2

[0053] Methylation of MT-ND6 gene can be used as a biomarker for early clinical screening, diagnosis and prognosis of hyperlipidemia (or hyperlipidemia)

[0054] Elevated triglyceride content in serum is one of the most important features of hyperlipidemia (or hyperlipidemia), such as figure 2 As shown in B, the methylation modification level of the MT-ND6 gene in human peripheral blood leukocytes is linearly positively correlated with the serum triglyceride level, suggesting that the methylation of the MT-ND6 gene can be a symptom of hyperlipidemia (or hyperlipidemia) Biomarkers for early clinical screening, diagnosis and prognosis.

Embodiment 3

[0056] The expression level of MT-ND6 can be used as a biomarker for early clinical screening, diagnosis and prognosis of hyperlipidemia (or hyperlipidemia), obesity, type 2 diabetes and metabolic syndrome and its complications

[0057] Such as figure 1 As shown in B and D, the mRNA expression level of MT-ND6 gene was decreased in type 2 diabetic humans and obese mice, and at the same time as figure 2 As shown in A, the methylation of MT-ND6 gene in human peripheral blood leukocytes is linearly negatively correlated with its mRNA expression. Since the methylation level of MT-ND6 was linearly positively correlated with serum triglyceride, HOMA-IR and glycosylated hemoglobin ( figure 2 B-D), it can be seen that the mRNA expression of MT-ND6 gene is linearly and negatively correlated with serum triglyceride, HOMA-IR and glycosylated hemoglobin content, suggesting that the expression level of MT-ND6 (mRNA and protein level) can be used as a sign of hyperlipidemia (or hyperlipid...

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PUM

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Abstract

According to an application of MT-ND6 as a new target in metabolic syndrome diagnosis and treatment drugs, expression of the MT-ND6 gene in peripheral blood leucocytes of type 2 diabetes patients and livers of obese mice is remarkably reduced, meanwhile, methylation level of the MT-ND6 gene is remarkably increased, linear correlation analysis shows that the methylation level of the MT-ND6 gene is in negative correlation with expression of mRNA of the MT-ND6 gene, and in positive correlation with insulin resistance index HOMA-IR, glycosylated hemoglobin content and serum triglyceride level, and knock-down of the MT-ND6 can cause mitochondrial dysfunction, increase liver lipid droplet accumulation and reduce insulin sensitivity, indicating that the MT-ND6 gene is closely related to metabolic syndrome. The invention provides a new target for clinical diagnosis and treatment of metabolic syndrome and complications thereof, and has important application value.

Description

technical field [0001] The invention belongs to the fields of biology and medicine, and particularly relates to the application of MT-ND6 as a new target in the diagnosis and treatment of metabolic syndrome. Background technique [0002] Metabolic syndrome is a pathological state in which a variety of metabolic disorders such as obesity, diabetes, and dyslipidemia are clinically abnormally aggregated, and insulin resistance is considered to be the pathological basis and core link of metabolic syndrome. With the development of society and economy and the change of people's lifestyle, metabolic syndrome and the chronic non-communicable diseases it causes have seriously threatened the health and quality of life of Chinese people. It is urgent to clarify its pathogenesis and seek more effective prevention targets important question. [0003] Mitochondria are key organelles that regulate glucose and lipid metabolism in cells. Under physiological conditions, the process of mitoch...

Claims

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Application Information

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IPC IPC(8): A61K45/00A61P5/00A61P5/50A61P3/10A61P1/16A61P3/06
CPCA61K45/00A61P5/00A61P5/50A61P3/10A61P1/16A61P3/06
Inventor 刘健康曹可柳絮云龙建纲臧伟进冯智辉
Owner XI AN JIAOTONG UNIV
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