A kind of hydrogel material with adjustable adhesion interface, preparation method and application thereof

A hydrogel and interface technology, applied in the field of hydrogels, can solve the problems of difficult adjustment of the underwater adhesion interface, achieve the in-situ cross-linking enhancement effect, increase the injectability and adhesion, and improve the adhesion performance. Effect

Active Publication Date: 2021-12-14
PEKING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Therefore, there are few reports on underwater adhesive hydrogels, and the corresponding underwater adhesive interface is also difficult to control.

Method used

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  • A kind of hydrogel material with adjustable adhesion interface, preparation method and application thereof
  • A kind of hydrogel material with adjustable adhesion interface, preparation method and application thereof
  • A kind of hydrogel material with adjustable adhesion interface, preparation method and application thereof

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Effect test

preparation example Construction

[0038] In an embodiment of the present invention, the preparation method of the diffusion-driven hydrogel material with adjustable adhesion interface includes: using ultrapure water and natural protein to prepare a gelatin solution, mixing the gelatin solution with a cross-linking agent and continuously stirring, Raw rubber is initially formed, and kneaded repeatedly until it is fully cross-linked; then a certain proportion of cross-linking blocker is added, and kneading is continued until the cross-linking blocker fully reacts to obtain a hydrogel with super-adhesive properties. glue material. Wherein, the mass fraction of the gelatin solution is 5-20wt%, the cross-linking agent adopts polyphenol, the mass ratio of the polyphenol to the gelatin solution is 1:1, and the mass ratio of the cross-linking agent to the gelatin solution is 30: 1~10:3.

[0039] In the embodiment of the present invention, the diffusion-driven hydrogel with adjustable adhesion interface is composed of...

Embodiment 1

[0044] Example 1: Adhesion Test Implementation

[0045] Cut all bonding substrates such as clean and smooth glass, steel, wood boards made of camphor trees, PDMS without any surface treatment, and various tissue viscera into rectangles of 20mm×9mm. Pig skin, pig muscle, and pig heart are all newly purchased from the local market without any additional treatment. In terms of underwater adhesion, about 0.1 g of G0.6-T0.6-U0.12 hydrogel was used for each test in about 40 ml of ultrapure water. After pressing for 10 seconds, the external pressure is removed, and the sample is placed in water alone to measure data at different time intervals. In addition, the present invention also considers the influence of different water environments, and the glass is bonded in seawater, detergent (SDS, 1Wt% solution), flocculant (PAAK, 1Wt% solution) and acetone. Pig skin was adhered with PBS, DMEM, acid (HCl, PH=6) and base (NaOH, PH=8). For each test, the actual bonded area on the bonded s...

Embodiment 2

[0048] In order to further verify the mechanism of small molecule diffusion-driven regulation of the bonding interface, the present invention tested the experimental data of cross-linking blocker diffusion with a specific scheme and built a simulation model, as follows:

[0049] Dissolve 0.8g of 4-dimethylaminobenzaldehyde (DMAB) in 500ml of ethanol, add 50ml of hydrochloric acid (37.5%wt%) after stirring continuously. Prepare cross-linking blocker standard solutions with different concentrations (0mM, 5mM, 10mM, 20mM, 50mM, 0.2M) in distilled water. The standard cross-linking blocker solution (50 μl) and the same volume of DMAB solution were mixed and reacted and placed in a 96-well plate. The absorbance at 420 nm was measured with a multimode microplate reader (Varioskan LUX, Throme Fisher) to obtain a cross-linking blocker standard curve. In actual measurement, fresh pigskin is cut into strips of 30 mm x 9 mm. According to the same underwater adhesion shear test method, u...

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Abstract

The invention discloses a diffusion-driven hydrogel material with an adjustable adhesion interface, a preparation method and an application thereof, and belongs to the field of hydrogel technology. The main components of the hydrogel material include protein, a cross-linking agent and a cross-linking blocking agent, the protein and water form a gelatin solution, and the gelatin solution is fully cross-linked to generate viscosity after mixing with the cross-linking agent, and the Cross-linking blockers induce the adhesion mechanism of hydrogel materials and precisely regulate the adhesion interface. The present invention uses small molecules as cross-linking blockers, and the hydrogel material with the cross-linking blockers not only increases the plasticity of the hydrogel, but also improves the adhesion performance of the hydrogel. The hydrogel material has good cell compatibility, antibacterial, degradability and underwater 3D printing performance, and has potential application prospects in the fields of smart adhesives, biomedicine, wearable devices, and environmental engineering. Opening up new possibilities for designing injectable, high-performance, and smart underwater adhesives.

Description

technical field [0001] The invention relates to a diffusion-driven hydrogel material with an adjustable adhesion interface, a preparation method and an application thereof, and belongs to the field of hydrogel technology. Background technique [0002] Marine animals such as mussels, jellyfish, barnacles, and oysters have natural underwater adhesion properties through catechol chemistry, micropatterning structures, and in situ nanoparticle formation. Hagfish in the ocean have their own unique underwater defense mechanism. When they encounter danger, they will eject mucus that can quickly congeal in the water. These mucus are held together by long protein threads. The mucus reacts with water to hinder the movement of the gills of predatory fish, thus forming an effective and unique defense mechanism. When the mucus encounters prey, the "stretch thickening" effect can significantly improve the toughness and adhesion of the mucus gel; in addition, when sliding over the hagfish,...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J3/075C08L89/00C08K5/13C09J189/00C09J11/06
CPCC08J3/075C09J189/00C09J11/06C08J2389/00C08K5/13
Inventor 黄建永解文月苏醒汪溥頔田卓灵
Owner PEKING UNIV
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