Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Novel diaryl nonane II free radical inhibitor in Saxifraga sinomontana as well as separation and preparation process and application of novel diaryl nonane II free radical inhibitor

A diaryl nonane, preparation technology, applied to the new diaryl nonane class II free radical inhibitor in saxifrage and its separation preparation process and application field, achieving low average cost of separation and suitable scale Production, easy-to-handle effects

Active Publication Date: 2021-07-13
CHINA ACAD OF SCI NORTHWEST HIGHLAND BIOLOGY INST
View PDF3 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no literature report on the separation, preparation and application of free inhibitors in saxifrage

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Novel diaryl nonane II free radical inhibitor in Saxifraga sinomontana as well as separation and preparation process and application of novel diaryl nonane II free radical inhibitor
  • Novel diaryl nonane II free radical inhibitor in Saxifraga sinomontana as well as separation and preparation process and application of novel diaryl nonane II free radical inhibitor
  • Novel diaryl nonane II free radical inhibitor in Saxifraga sinomontana as well as separation and preparation process and application of novel diaryl nonane II free radical inhibitor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] The separation and preparation process of the new diarylnonane class II free radical inhibitors in saxifrage, specifically includes the following steps:

[0042] Step 1, extraction: take 170g of saxifrage whole herb and dry it in the shade, coarsely crush it and extract it with methanol at a solid-to-liquid ratio of 1g: 5mL, extract 4 times at room temperature, each time for 2h, filter and combine the filtrates, that is, filtrate A, the The filtrate A is dried under reduced pressure to obtain the saxifrage extract, according to the amount of polyamide: the amount of the saxifrage extract=3:1, mix the sample and dry under reduced pressure, and then the mixed sample of the saxifrage extract is obtained ; Among them, the conditions of the two decompression drying are: vacuum degree 50mbar, temperature 40°C, and the mixed sample of the obtained saxifrage extract is 70.8g;

[0043] Step 2, online free radical inhibitor component screening: Add methanol with a volume concentr...

Embodiment 2

[0049] The separation and preparation process of the new diarylnonane class II free radical inhibitors in saxifrage, specifically includes the following steps:

[0050] Step 1, extraction: take 500g of saxifrage whole herb and dry it in the shade, coarsely crush it and extract it according to the ratio of solid to liquid: 1g: 100mL of methanol, extract twice at room temperature, each time for 4h, filter and combine the filtrates, that is, filtrate A, the The filtrate A is dried under reduced pressure to obtain the saxifrage extract, according to the amount of polyamide: the amount of the saxifrage extract=3:1, mix the sample and dry under reduced pressure, and then the mixed sample of the saxifrage extract is obtained ; Among them, the conditions of the two decompression drying are: the vacuum degree is 250mbar, the temperature is 60°C, and the mixed sample of the obtained saxifrage extract is 198.5g;

[0051] Step 2, online free radical inhibitor component screening: add meth...

Embodiment 3

[0057] The separation and preparation process of the new diarylnonane class II free radical inhibitors in saxifrage, specifically includes the following steps:

[0058] Step 1, extraction: take 1000g of saxifrage whole herb and dry it in the shade, coarsely crush it and extract it according to the ratio of solid to liquid: 1g: 50mL of methanol, extract 3 times at room temperature, each time for 3h, filter and combine the filtrates, that is, filtrate A, the The filtrate A is dried under reduced pressure to obtain the saxifrage extract, according to the amount of polyamide: the amount of the saxifrage extract=3:1, mix the sample and dry under reduced pressure, and then the mixed sample of the saxifrage extract is obtained ; Among them, the conditions of the two decompression drying are: the vacuum degree is 100mbar, the temperature is 50°C, and the mixed sample of the obtained saxifrage extract is 389.4g;

[0059]Step 2, online free radical inhibitor component screening: add met...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a novel diaryl nonane II free radical inhibitor in Saxifraga sinomontana as well as a separation preparation process and application of the diaryl nonane II free radical inhibitor. The specific preparation process comprises the following five steps: extraction, on-line free radical inhibitor component screening, medium-pressure chromatography coarse separation in a microporous resin column, on-line free radical inhibitor screening and reversed-phase preparative column preparation. The novel diaryl nonane Saximonsin B free radical inhibitor in the Saxifraga sinomontana prepared by the method can be applied to preparation of free radical inhibition medicines or health foods, and is specifically used as an effective component to be prepared into various medicinal preparations or health foods according to any pharmaceutically or food science acceptable carrier. An extraction solvent, a microporous resin column, a reversed-phase chromatographic column separation solvent and materials for reversed-phase chromatographic separation in the preparation process can be recycled; and the raw material source is wide, large-scale operation can be realized in the process steps such as methanol room-temperature cold leaching extraction, and high-pressure preparative chromatographic separation can ensure that the purity of the product is greater than 95%.

Description

technical field [0001] The invention relates to the technical field of separation of new diarylnonane free radical inhibitors in saxifrage, in particular to a new diarylnonane II free radical inhibitor in saxifrage and its separation and preparation process and application. Background technique [0002] Saxifraga montana is a perennial herb of Saxifragaceae (Saxifragaceae) genus Saxifraga, Tibetan medicine name: "Hanrenjiaomu", mainly distributed in Shaanxi, Qinghai, and western Sichuan in China , northwestern Yunnan and eastern and southern Tibet. Main effects: clearing heat and detoxifying, calming the liver and suppressing yang. Cure mainly damp-heat in the liver and gallbladder, damp-heat in the spleen and stomach, carbuncle and sores are used for headaches caused by hyperactivity of liver-yang. Modern pharmacological studies have proved that phenols are the main active ingredients of saxifrage plants. According to literature reports, phenolic compounds have good fre...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C07C49/248C07C45/78C07C45/79A61K31/12A61P39/06A23L33/105
CPCC07C49/248A61P39/06A23L33/105A23V2002/00A23V2200/302Y02A50/30
Inventor 党军王启兰陶燕铎
Owner CHINA ACAD OF SCI NORTHWEST HIGHLAND BIOLOGY INST
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com