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Novel Chinese herbal compound for preventing and treating sjogren syndrome and preparation method and application thereof

A technology of Sjogren's syndrome, traditional Chinese medicine

Active Publication Date: 2021-07-16
KUNMING MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, when it is used alone, the effect is slow, and it cannot quickly improve the symptoms of dry mouth and eyes, and cannot quickly reduce the degree of glandular lymphocyte infiltration and reduce the expression of autoantibodies.
In the patent 201210296796.0, the traditional Chinese medicine compound with Paeoniae Alba as one of the main traditional Chinese medicines shows that it can effectively inhibit rheumatoid factor and antibody indicators, but it has no effect on lymphocyte infiltration in glands specific to dryness, autoantibodies SSA, SSB, ANA And inflammatory TNF-α, BAFFR factors and other intervention effects are not good
In addition, there are also some traditional Chinese medicine compound prescriptions used in the treatment of Sjögren’s syndrome, such as patents 201210345391.1 and 201610918771.8, but they have the disadvantages of more traditional Chinese medicine flavors, more complex formulas and manufacturing processes, and more daily doses.

Method used

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  • Novel Chinese herbal compound for preventing and treating sjogren syndrome and preparation method and application thereof
  • Novel Chinese herbal compound for preventing and treating sjogren syndrome and preparation method and application thereof
  • Novel Chinese herbal compound for preventing and treating sjogren syndrome and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Take 2g of Prunella vulgaris, 2g of Desmodium, 2g of Hedyotis diffusa, 2g of chrysanthemum, and 2g of honeysuckle. Take the above five Chinese herbal medicines, extract them with three times of distilled water, filter, combine the filtrates, and concentrate the filtrates to 100mL.

Embodiment 2

[0051] Take 7.5g of Prunella vulgaris, 4g of Desmodium, 7.5g of Hedyotis diffusa, 12g of Chrysanthemum, and 18g of Honeysuckle. Take the above five Chinese herbal medicines, extract them with distilled water three times, filter, combine the filtrates, and concentrate the filtrates to 100mL.

Embodiment 3

[0053] Prunella vulgaris 15g, Desmodium 12g, Hedyotis diffusa 15g, Chrysanthemum 10g, Honeysuckle 15g, take the above five Chinese herbal medicines, extract them with distilled water three times, filter, combine the filtrates, and concentrate the filtrates to 100ml.

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Abstract

The invention discloses a novel Chinese herbal compound for preventing and treating the sjogren syndrome and a preparation method thereof, and is characterized in that Chinese herbal medicine components are reasonably matched, and the effective components of the formula comprise spica prunellae, herba lysimachiae, herba hedyotidis diffusae, flos chrysanthemi and flos lonicerae which are all Chinese herbal medicine components. The preparation method comprises the following process and steps: decocting the spica prunellae, the herba lysimachiae, the herba hedyotidis diffusae, the flos chrysanthemi and the flos lonicerae with 5 times of distilled water and 3 times of distilled water, performing decocting for 1 hour each time, then merging water decoctions, and then performing vacuum concentration. Animal experiment screening proves that the obtained concentrated solution has very good effects of improving dry eyes, improving gland functions, reducing autoantibody levels and resisting inflammations. Maximum dosage experiments prove that the concentrated solution has relatively high clinical safety. The novel Chinese herbal compound is used for preventing and treating the sjogren syndrome mainly with dry eyes, invasion of lymphocytes into secretory glands and inflammation, and the sjogren syndrome is not prone to relapse.

Description

technical field [0001] The invention relates to the medical application of a traditional Chinese medicine compound for preventing and treating Sjögren's syndrome, in particular to the application of the compound in treating Sjögren's syndrome. Background technique [0002] Sjogren's syndrome ( SS), also known as Sjögren's syndrome, is a chronic inflammatory autoimmune disease that primarily affects the exocrine glands. It is divided into primary and secondary categories. The typical clinical manifestations are salivary gland and lacrimal gland damage and decreased function, resulting in dry mouth and dry eyes, while other exocrine glands and other organs outside the glands are involved, resulting in multi-system damage. There are a variety of autoantibodies and high immunoglobulins in the patient's serum. Sjögren's syndrome occurs in women after menopause or 30-40 years old, and the incidence rate is about 0.3-0.4%, and it is as high as 0.77% in the elderly population. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/748A61P37/02A61P29/00A61P27/02A61P1/02
CPCA61K36/536A61K36/185A61K36/53A61K36/748A61K36/287A61K36/355A61P37/02A61P29/00A61P27/02A61P1/02A61K2236/331A61K2300/00
Inventor 郝静超赵荣惠文凤
Owner KUNMING MEDICAL UNIVERSITY
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