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Mixed triglyceriges

A technology of triglyceride and tributyrin, which can be used in drug combination, fatty acid esterification, edible oil/fat, etc., and can solve problems such as limiting blood ketones

Pending Publication Date: 2021-07-30
SOC DES PROD NESTLE SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, adverse consequences of gastrointestinal intolerance, such as diarrhea and stomach cramps, are associated with high dose intake (>10g), which limits the amount that can be ingested at one time, and thus the amount of blood ketones produced

Method used

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  • Mixed triglyceriges
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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0167] Example 1—Preparation of Butylated Triglycerides (TAG)

[0168] Compositions comprising butylated TAG were produced by chemical transesterification between tributyrin and tricaprylycerin in the presence of a sodium methoxide catalyst.

[0169] Use the following steps:

[0170] reaction

[0171] • Tricaprylycerin (Neobee 895 from Stepan) and tributyrin were added sequentially to the multifunctional reactor L2600 at room temperature. Set aside 1 liter of tricaprylycerin to facilitate the addition of sodium methoxide.

[0172] · While stirring, deaerate with nitrogen gas.

[0173] • Heat the reactor to 60°C.

[0174] • Add sodium methoxide suspended in 1 liter of tricaprylycerin (stir before addition).

[0175] • Heat the mixture to 80°C under an inert atmosphere (nitrogen) for 3 h (start timing at 60°C.

[0176] Post-processing

[0177] • Cool the mixture to below 60°C.

[0178] • The mixture was washed in deionized water (approximately 8 L) until neutral pH...

Embodiment 2

[0202] Example 2 - (In Vivo) Administration of Butylated Triglycerides (TAG)

[0203] After an overnight fast, at time 0, 15 healthy volunteers orally administered 15 g of the C4C8 butylated triglyceride "MCT C4 / C8" of Example 1 emulsified in 70 mL of 5% milk protein aqueous solution, and 15 healthy volunteers Patients were orally administered 15 g of medium chain triglycerides, wherein a mixture of "MCT" with a C8:C10 ratio of about 58:42 was emulsified in 70 mL of a 5% milk protein aqueous solution. At 30 minutes, a standard breakfast is served and eaten within 15 minutes. Blood samples were collected at regular intervals over 4 h via a venous catheter and analyzed for C3, C4, C8, 3-hydroxybutyric acid (BHB) and acetoacetate (AcAc) in plasma by UPLC-MSMS.

[0204] The mean total plasma ketone (BHB and AcAc) levels of 15 patients in each treatment group: C4C8 butylated triglyceride "MCT C4 / C8" group and MCT group within 4 hours are shown in figure 1 middle. as from figu...

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Abstract

The invention provides a composition comprising a compound having the formula (1), (2), (3), (4) or combinations thereof, wherein n1, n2, n3, n4, n5 and n6 are independently 4 to 10.

Description

technical field [0001] The present invention relates to a dietary source of triglycerides comprising butyric acid having improved organoleptic properties. The present invention also provides triglycerides comprising butyric acid which provide a rich source of ketones. Background technique [0002] Salts and esters of butyric acid are known as butyrates or butanoates. Butyric acid in ester form is present in many foods such as milk, especially of goat, sheep, cow, camel and buffalo, and dairy products such as butter and cheese such as Parmesan. Butyric acid is also a product of anaerobic fermentation, for example, as a product of fermentation produced by gut microbiota. Tributyrin is a triglyceride composed of three ester functional groups, having three butyrate moieties and a glycerol backbone. Under hydrolysis conditions, such as those occurring during digestion, tributyrin may be a source of three moles of butyric acid per mole of tributyrin. [0003] The multiple bene...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23D9/02A61K31/215C11C3/10
CPCA23D9/02C11C3/10A61K31/225A61P35/00A61P9/10
Inventor C·布朗夏尔B·屈埃努F·德塔亚E·福布斯-布洛姆H·厄特林A·帕汀
Owner SOC DES PROD NESTLE SA