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Topical agent

A technology for external preparations and extracts, which is applied in the field of external preparations containing tranexamic acid to achieve a good sense of use and good appearance

Pending Publication Date: 2021-10-22
MARUZEN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] However, although tranexamic acid is water-soluble, on the other hand, there is a problem that crystallinity is very high, and crystals are easily precipitated by evaporation of water.

Method used

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Examples

Experimental program
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Effect test

Embodiment

[0086] Hereinafter, the present invention will be specifically described by giving test examples and examples, but the present invention is not limited by the following examples. It should be noted that, in the following examples, unless otherwise specified, “%” in the composition means mass %, and ratios mean mass ratio. "Noni Juice" and "Lemon Juice" in the table are the amount of juice, and others are the converted amount of solid content.

[0087] For the following ingredients, the tranexamic acid crystallization inhibition test was carried out at the concentrations stated in the table. Record the results together in the table.

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Abstract

This topical agent has the effect of inhibiting the crystallization of tranexamic acid, and contains (A) one or more selected from tranexamic acid, tranexamic acid derivatives, and salts thereof, and (B) one or more selected from groups: (B-1) marjoram extract, silver vine extract, plum extract, Japanese maple extract, multiflora rose fruit extract, Malva mauritiana L. extract, Arnica extract, eucalyptus extract, and royal jelly extract; (B-2) noni fruit juice and lemon juice; and (B-3) conchiolin hydrolysate and silk hydrolysate.

Description

technical field [0001] The present invention relates to external preparations containing tranexamic acid. [0002] Background of the invention [0003] Tranexamic acid has hemostatic and anti-inflammatory effects, and is widely used in toothpaste, pharmaceuticals, and the like. In addition, it has the effect of improving rough skin and whitening effect, and is also used as an external preparation for skin or hair such as cosmetics. [0004] However, although tranexamic acid is water-soluble, on the other hand, there is a problem that crystallinity is very high and crystals are easily precipitated by evaporation of water. As a method for suppressing the crystallization of such tranexamic acid, combined use of phytic acid (Patent Document 1: JP-A No. 2018-48097) and polyhydroxy acid (Patent Document 2: JP-A No. 2013-121955) has been proposed. method etc. However, a method with a better effect of inhibiting the crystallization of tranexamic acid is desired. [0005] prior ar...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/44A61K8/64A61K8/9789A61K8/98A61K47/42A61K47/46A61K31/195A61P7/04A61P29/00A61P17/16A61Q19/00A61Q19/02
CPCA61P29/00A61K47/42A61K8/9789A61Q19/00A61K8/64A61K47/46A61K8/98A61K8/44A61K31/195A61P7/04A61P17/16
Inventor 鸟家圭悟池田良
Owner MARUZEN PHARMA