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Cell inflammatory factor adsorbent and preparation method thereof

A technology of inflammatory factors and adsorbents, which is applied in the field of cell inflammatory factor adsorbents and its preparation, can solve the problems of low efficiency of coupling ligands, and achieve improved selective scavenging ability, increased biocompatibility, and high coupling efficiency Effect

Pending Publication Date: 2021-11-02
北京中科太康科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to epoxidation and then coupled ligands, the efficiency of coupling ligands is not high

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] 1-1 Pretreatment

[0038] Take 20% wt glycine aqueous solution, adjust the pH of the solution to 9 with 0.5% NaOH, or use other low-concentration strong bases to adjust the solution to alkaline; measure 50 ml of the prepared glycine solution, and then add 26.4 g of benzoyl chloroformate Ester, mix well, and stir for 1 h at 40°C with a stirrer rotating speed of 100 rpm for later use. The chloroformate can be benzyl chloroformate or tertiary butyl chloroformate, and the molar ratio to glycine should be controlled between 1:1 and 3:1.

[0039] 1-2 Conjugated Glycine

[0040] Take 10g of polystyrene chlorine balls (commercially available, the parameters are: chlorine content 20%, pore diameter 2~60nm, specific surface area not less than 500㎡ / g), add 50ml dichloroethane to swell for 2h, and then add 10ml thionyl chloride respectively and 20 ml of the solution obtained in step 1-1, and the reaction was stirred at a temperature of 40° C. for 48 hours, and the stirring speed ...

Embodiment 2

[0044] 2-1 Pretreatment

[0045] Take 20% wt glycine aqueous solution, drop 0.5% NaOH solution to pH 10, measure 30ml of the prepared glycine solution, then add 12.8g tertiary butyl chloroformate, mix well, and stir for 1h at room temperature at 100rpm. use.

[0046] 2-2 Conjugated Glycine

[0047] Take 10g polystyrene chlorine ball (commercially available, the parameters are: chlorine content 18%, pore diameter 5~50nm, specific surface area not less than 500㎡ / g), add 50ml dichloroethane to swell for 2h, and then add 10ml thionyl chloride respectively 20 ml of the solution obtained from 2-1 was stirred and reacted at 40° C. for 24 hours, and the stirring speed was 100 rpm. Then add 10ml of ether and 30ml of 2% cold trifluoroacetic acid solution, reduce the speed of the stirrer to 50rpm and continue the reaction for 8h, extract with ethyl acetate for 8h, then wash with alcohol, wash the microspheres with water, and dry for later use.

[0048] 2-3 Conjugated valine

[0049] ...

Embodiment 3

[0051] 3-1 Pretreatment

[0052] Take 20% wt glycine aqueous solution, add 0.5% NaOH dropwise to adjust the solution to be alkaline, measure 20 ml of the prepared glycine solution, then add 8.5 g of tertiary butyl chloroformate, mix well, and stir at 40°C for 1 hour at 100 rpm. back up.

[0053] 3-2 Conjugated Glycine

[0054] Take 10g polystyrene chlorine ball (commercially available, the parameters are: chlorine content 18%, pore diameter 5~50nm, specific surface area not less than 500㎡ / g), add 50ml dichloroethane to swell for 2h, and then add 10ml thionyl chloride respectively and 20ml of the solution obtained from 2-1, stirred and reacted at 40°C for 24 hours, rotating at 100rpm, then added 10ml of ethyl acetate and 30ml of 2% cold trifluoroacetic acid solution, reduced the rotating speed to 50rpm and continued the reaction for 8h, and then added ethyl acetate Ester extraction for 8h, then alcohol washing, water washing of the microspheres, and drying for use.

[0055] 3-...

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Abstract

The invention discloses a cell inflammatory factor adsorbent and a preparation method. A skeleton of the cell inflammatory factor adsorbent is a polystyrene chlorine ball, and glycine is coupled to a carrier by utilizing the activity of benzyl chloride on the skeleton. Amino acids are directly coupled by utilizing the activity of benzyl chloride on polystyrene chlororine beads, the coupling efficiency is high, and amino acids such as valine and the like can be linked by further modifying the coupled amino acids, so that the chain linking efficiency is high.

Description

technical field [0001] The invention relates to a polymer biomedical material, in particular to a cell inflammatory factor adsorbent applied to blood perfusion and a preparation method thereof. Background technique [0002] With economic development, the pace of urbanization continues to accelerate, urban clusters and population density continue to increase, and transportation convenience continues to improve, which not only facilitates people's lives and travel, but also increases the risk of infectious disease transmission. In addition, economic activities lead to environmental pollution. Increasingly serious, these have brought new challenges to public health security and people's health. [0003] Recent studies of COVID-19 cases show that most elderly people and those with underlying medical conditions (eg, hypertension, chronic obstructive pulmonary disease, diabetes, cardiovascular disease) rapidly develop acute respiratory distress syndrome, septic shock, and even sep...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J20/28B01J20/26B01J20/30
CPCB01J20/28019B01J20/261B01J20/28011B01J2220/44Y02P20/55
Inventor 刘群奇白珂
Owner 北京中科太康科技有限公司
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