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Cancer prognosis

A cancer and patient technology, applied in the field of predicting the treatment response of cancer patients to anticancer therapy, can solve the problem of increasing clinical decision-making

Pending Publication Date: 2021-11-05
F HOFFMANN LA ROCHE & CO AG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Thus, there is an unmet need for larger sample sizes to enable more accurate predictions that increase confidence in clinical decision making

Method used

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  • Cancer prognosis
  • Cancer prognosis
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Embodiment Construction

[0229] Exemplary methods of modeling and scoring will now be described. It will be appreciated that alternative statistical techniques for analyzing the contribution of parameters to mortality risk may be utilized to form the model. Examples include all of parameters (i) to (xxvi) or (i) to (xxix), but as noted above, the method can be adapted to select only these parameters and / or to include parameters other than (i) to (xxvi) respectively Or parameters other than (i) to (xxix).

[0230] Two examples of models and scores are now described as Roche Prognostic Scale (RoPro) 1 and 2. RoPro1 is the weighted sum of the 26 parameters (i) to (xxvi) of the difference between the patient data and the mean value of the corresponding reference parameter, while RoPro 2 is the weighted sum of the 29 parameters (i) to (xxvi) of the difference between the patient data and the mean value of the corresponding reference parameter xxix). A higher RoPro indicates a higher risk of death and a ...

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Abstract

The application relates to methods of assessing whether a cancer patient is at high risk or low risk of mortality, as well as methods of predicting the treatment response to an anti- cancer therapy in a cancer patient. The methods of the invention find application in the selection of patients for clinical trials, the selection of patients for treatment with anti-cancer therapies, monitoring cancer patients during treatment with an anti-cancer therapy, and evaluating the results of clinical trials for anti-cancer therapies, for example.

Description

technical field [0001] The present invention relates to methods of assessing whether a cancer patient is at high or low risk of death, and methods of predicting the therapeutic response of a cancer patient to anticancer therapy. The methods of the invention are applicable, for example, to selecting patients for clinical trials, selecting patients for treatment with anticancer therapies, monitoring cancer patients during treatment with anticancer therapies, and evaluating the results of clinical trials of anticancer therapies. Background technique [0002] Factors affecting life expectancy are very important in public health (Ganna & Ingelsson, 2015). In oncology, prediction of patient survival helps optimize patient management (Halabi & Owzar, 2010). By understanding which variables are prognostic for outcome, it is possible to gain insight into disease biology, which could allow individualized treatment for patients and perhaps improve clinical trial design, conduct, and d...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/574
CPCG01N33/574G01N33/57484G01N2800/52G01N2800/54G16H50/30G16B5/20G16B40/20
Inventor D·路汀尔A·鲍尔·梅伦T·贝克尔
Owner F HOFFMANN LA ROCHE & CO AG