Application of artemisia annua extract in preparing preparation for treating or preventing AD

A technology of Artemisia annua and water extract, which is applied to the application field of Artemisia annua water extract in the prevention or treatment of Alzheimer's disease, and can solve the problems of inability to extract artemisinin compounds, structural damage, improper extraction method, etc. To reduce the loss of mitochondrial transmembrane potential, improve activity, and avoid secondary damage

Pending Publication Date: 2021-11-19
UNIVERSITY OF MACAU
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Artemisinin compounds are generally sensitive to heat and are almost insoluble in water. Alcohol extraction or organic solvent extraction is generally used. If the extraction method is improper, its structure is easily destroyed or artemisinin compounds cannot be extracted.

Method used

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  • Application of artemisia annua extract in preparing preparation for treating or preventing AD
  • Application of artemisia annua extract in preparing preparation for treating or preventing AD
  • Application of artemisia annua extract in preparing preparation for treating or preventing AD

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0037] For convenience of comparison, the Artemisia annua extract ZWH2880 used in the following experiments was prepared as follows.

[0038] Preparation of Artemisia annua Extract ZWH2880

[0039] S1) Take Artemisia annua and add 10 times of water to soak for 2 hours, then start heating, start timing when the water boils, keep boiling and extract for 2 hours,

[0040] Take the filtrate;

[0041] S2) Add 8 times of water to the medicinal dregs, heat and boil for extraction for 2 hours, and take the filtrate;

[0042] S3) Concentration: Combine the two extracts, raise the temperature of the concentrator to 65°C, and vacuum to -0.08MPa, and concentrate the relative density of the extract to 1.12;

[0043] S4) Spray drying: the equipment controls the air inlet temperature at 180°C and the outlet air temperature at 90°C, and dries the concentrate to be sprayed.

[0044] The obtained product is recorded as Artemisia annua extract ZWH2880.

[0045] Effects of different concentra...

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Abstract

The invention discloses an application of an artemisia annua extract in preparing a preparation for treating or preventing AD. The artemisia annua boiled water extract can unexpectedly improve the learning and memory ability of Alzheimer's disease transgenic model mice, prevent nerve cell death caused by oxidative damage, promote mitochondrial transmembrane potential recovery, reduce amyloid plaque deposition, nerve fiber entanglement and neuron loss, and provides an experimental basis for clinical research on treatment of the AD.

Description

technical field [0001] The invention relates to a new application of the extract of Artemisia annua, in particular to the application of the water extract of Artemisia annua in preventing or treating Alzheimer's disease (AD). Background technique [0002] Alzheimer's disease (AD) is one of the most devastating diseases affecting older adults. Amyloid-β (Aβ) accumulation and downstream pathological events (eg, inflammation, oxidative stress) play a key role in the pathogenesis of AD. Including Tau hyperphosphorylation, glial activation, neuroinflammation, neuronal loss, and synaptic dysfunction, resulting in great economic burden and social pressure. Alzheimer's disease in the elderly, whose incidence increases year by year with disease (AD), is the most common form of population aging worldwide and imposes a huge social and economic burden on families and societies. [0003] At present, the etiology of Alzheimer's disease is still unclear, and a large number of studies hav...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/282A61P25/28A21D13/06A23C9/152A23G3/36A23G3/48A23L2/385A23L2/52A23L7/10A23L13/40A23L19/00A23L33/105
CPCA61K36/282A61P25/28A23L33/105A23L2/385A23L2/52A23G3/364A23G3/48A21D13/06A23C9/152A23L13/42A23L7/10A23L7/198A23L19/00A61K2236/331A61K2236/39A61K2236/53A61K2236/51A23V2002/00A23V2200/322A23V2250/21
Inventor 郑文华
Owner UNIVERSITY OF MACAU
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