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Application of compounds in preparation of medicines for inhibiting formation and/or growth of calculus

A technology for compounds and uses, applied in the directions of drug combinations, pharmaceutical formulations, organic active ingredients, etc., can solve problems such as formation and growth of stones that have not yet been found, and achieve the effects of good application prospects, good safety, and good protective effects.

Active Publication Date: 2022-01-18
WEST CHINA HOSPITAL SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Although the above three compounds have certain effects in medicine, they have not been found to inhibit stone formation and growth

Method used

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  • Application of compounds in preparation of medicines for inhibiting formation and/or growth of calculus
  • Application of compounds in preparation of medicines for inhibiting formation and/or growth of calculus
  • Application of compounds in preparation of medicines for inhibiting formation and/or growth of calculus

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Effect test

Embodiment 1

[0048] Embodiment 1, compound inhibits the research of calculus formation and growth

[0049] 1. Experimental animals

[0050] Thirty SD male rats, SPF grade, weighing 250-300 g, were purchased from Chengdu Dashuo Experimental Animal Co., Ltd. (ethical record number: 2018190A), and were reared adaptively for 1W in the West China Animal Room before use. Divided into normal control group; kidney stone model group; citric acid intervention positive control group; salicylic acid, gentisic acid and succinic acid intervention experimental group.

[0051] 2. In vitro crystal formation experiment

[0052] In vitro crystal formation assays can be used to quickly and easily evaluate the activity of compounds for screening potential anti-calculus inhibitors. The effects of compounds on the nucleation, growth and aggregation of calcium oxalate crystals were evaluated by in vitro crystal formation experiments. To simulate the formation of calcium oxalate in urine, a combination of calci...

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Abstract

The invention provides application of compounds in preparation of medicines for inhibiting formation and / or growth of calculi, and belongs to the technical field of biological medicine. The compounds are compounds as shown in a formula I or a formula II, or salts thereof, or stereoisomers thereof, or hydrates thereof, or solvates thereof, or prodrugs thereof. Specifically, the compounds are salicylic acid, gentisic acid and succinic acid. Studies find that the salicylic acid, the gentisic acid and the succinic acid can effectively inhibit crystal formation and growth, and can be used as crystal inhibitors for preparing medicines for inhibiting formation and growth of the calculi. Wherein the succinic acid not only has an optimal effect of inhibiting formation and growth of the calculi, but also has a good protection effect on kidneys, and is good in safety. The invention provides a new target and a treatment scheme for intervening in-vivo calculus formation and growth, and has a good application prospect.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and specifically relates to the use of compounds in the preparation of medicines for inhibiting stone formation and / or growth. Background technique [0002] Urolithiasis is one of the common diseases of urinary system, second to urinary tract infection and prostate disease. Uroliths can be divided into upper urinary tract stones (kidney, ureteral stones) and lower urinary tract stones (bladder, urethral stones), which can be regarded as two types of stones. Urolithiasis is a manifestation of abnormal mineralization of the human body, that is, under normal circumstances, mineralization should not occur at the site or excessive mineralization, which is closely related to the activity and metabolism of cells throughout the body. [0003] The occurrence and development of stones is a dynamic process. Stone formation generally goes through the following steps: crystal nucleus formation, crystal g...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/60A61K31/194A61K31/192A61P13/04A61P13/12A61P13/10A61P13/02
CPCA61K31/60A61K31/194A61K31/192A61P13/04A61P13/12A61P13/10A61P13/02
Inventor 解慧琪张秀珍雷雄心邹晨宇
Owner WEST CHINA HOSPITAL SICHUAN UNIV
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