Three-layer co-extrusion polyolefin infusion film and preparation method thereof

A three-layer co-extrusion, infusion film technology, applied in the field of infusion film, can solve the problems of high cost, complex process, many layers of infusion film, etc., achieve good compatibility and combination, and improve the effect of antibacterial properties

Pending Publication Date: 2022-01-21
JIMIN HEALTH MANAGEMENT CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantages are that the infusion film has many layers, the process is complex, and the cost is high, and the antibacterial properties of polyethylene, polypropylene and SEBS used are not good for the safety and stability of infusion drugs during use.

Method used

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  • Three-layer co-extrusion polyolefin infusion film and preparation method thereof

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preparation example Construction

[0028] In addition, the preparation method of chitosan antibacterial modified polypropylene comprises the following steps: 4 ~10 5Mix and swell chitosan in lactic acid with a pH of 3-5, add 2-methyl-2-octenal and dimethyl sulfoxide and react at 30-50°C for 2-4 hours; adjust the pH to neutral , then add propylene monomer, sodium persulfate, polyoxypropylene ether and water to carry out polymerization reaction at 70-90°C for 3-5 hours, the polymerization pressure is 3-4MPaG, chitosan, 2-methyl-2-octene The mass ratio of aldehyde, propylene monomer, sodium persulfate and polyoxypropylene ether is 10-15:3-5:45-55:1-2:1-2; then methanol and saturated saline are added to break the emulsion, and then After filtering, washing and drying successively, the chitosan antibacterial modified polypropylene is obtained.

[0029] The preparation method of the above-mentioned three-layer co-extruded polyolefin infusion film comprises the following steps: the weather-resistant layer, the core ...

Embodiment 1

[0031] The three-layer co-extruded polyolefin infusion film includes a weather-resistant layer, a core layer and an inner sealing layer from outside to inside. The raw material of the weather-resistant layer includes polypropylene, and the thickness is 30 μm. The raw materials of the core layer include polyethylene, polypropylene and SEBS, and the thickness is 80 μm. The raw materials of the inner sealing layer include 43% chitosan antibacterial modified polypropylene and 57% SEBS, and the thickness is 70 μm. The total thickness of the prepared infusion film is 180 μm, and the materials such as polyethylene, polypropylene and SEBS are all medical grade materials, among which, the melting point of polypropylene is 140°C, and the melting point of polyethylene is 110°C; the styrene of SEBS is The block content is 32%.

[0032] In addition, the preparation method of chitosan antibacterial modified polypropylene comprises the following steps: the relative molecular weight is 8*10...

Embodiment 2

[0035] The three-layer co-extruded polyolefin infusion film includes a weather-resistant layer, a core layer and an inner sealing layer from outside to inside. The raw material of the weather-resistant layer includes polypropylene, and the thickness is 30 μm. The raw materials of the core layer include polyethylene, polypropylene and SEBS, and the thickness is 70 μm. The raw materials of the inner sealing layer include 35% chitosan antibacterial modified polypropylene and 65% SEBS, and the thickness is 65 μm. The prepared transfusion film has a total thickness of 165 μm, and the polyethylene, polypropylene, SEBS and other materials used are all medical grade materials, among which, the melting point of polypropylene is 140°C, and the melting point of polyethylene is 95°C; the styrene of SEBS is The block content was 17%.

[0036] In addition, the preparation method of chitosan antibacterial modified polypropylene comprises the following steps: the relative molecular weight i...

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Abstract

The invention relates to the technical field of infusion films, and discloses a three-layer co-extrusion polyolefin infusion film and a preparation method thereof, and the three-layer co-extrusion polyolefin infusion film sequentially comprises a weather-proof layer, a core layer and an inner sealing layer from outside to inside; the raw material of the weather-proof layer comprises polypropylene; the raw materials of the core layer comprise polyethylene, polypropylene and SEBS; and the inner sealing layer is prepared from the following raw materials: 35 to 55% of chitosan antibacterial modified polypropylene and 45 to 65% of SEBS (Styrene-Ethylene-Butylene-Styrene). The polyethylene, the polypropylene, the SEBS and other materials adopted in the invention are all medical-grade materials, so that the product can be in direct contact with drugs, and the materials have good compatibility and combinability; the inner sealing layer comprises chitosan antibacterial modified polypropylene, so that the antibacterial property of the infusion film is improved, and the safety and the stability of an infusion medicine in the using process are facilitated; and the method does not need irradiation crosslinking, does not need an adhesive, adopts a whole-process automatic control system and a fault alarm system, and can be used for industrial large-scale application.

Description

technical field [0001] The invention relates to the technical field of transfusion membranes, more specifically, the invention relates to a three-layer co-extruded polyolefin transfusion membrane and a preparation method thereof. Background technique [0002] Infusion products are the most widely used category of pharmaceutical products, and their safety, stability and effectiveness have always attracted the attention of the industry. The choice of packaging container is an important factor affecting the quality of infusion products. In recent years, the general trend of domestic infusion product packaging has developed from glass bottles and plastic bottles to soft bags. With the continuous advancement of science and technology, the composition and structure of soft bag film materials are also undergoing continuous changes. The PVC soft bag material contains polyvinyl chloride monomer, which is not conducive to human health. At the same time, the PVC soft bag has a thick ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B32B27/08B32B27/18B32B27/30B32B27/32C08L23/12C08L23/06C08L53/02C08L51/00C08J5/18C08F251/00C08F210/06C08F216/34B29C55/28B29L7/00
CPCB32B27/32B32B27/08B32B27/302B32B27/18C08J5/18C08F251/00B29C55/28C08J2323/12C08J2323/06C08J2353/02C08J2451/00C08J2453/02C08J2351/00B32B2307/7145B29L2007/00C08F210/06C08F216/34
Inventor 李慧慧
Owner JIMIN HEALTH MANAGEMENT CO LTD
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