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A kind of lignan compound in lilac and its preparation method and application

A compound, the technology of lilac, which is applied in the field of medicine, can solve the problem of less lilac stems, achieve significant effects, calm the nerves, and reduce the amount of NO released by cells

Active Publication Date: 2022-03-08
JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the research on lilac at home and abroad is mainly concentrated on the flower buds, leaves and bark, and there is little research on the stem, and the stem is also called Tibetan agarwood in Tibetan areas. There are few reports on composition research, therefore, it is of great significance to carry out the separation and preparation of chemical components of lilac stems

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  • A kind of lignan compound in lilac and its preparation method and application
  • A kind of lignan compound in lilac and its preparation method and application
  • A kind of lignan compound in lilac and its preparation method and application

Examples

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Effect test

Embodiment 1

[0042] This example provides a lignan compound in lilac, the name of the lignan compound is 2-(benzo[D][1,3]dioxolane-5-methylene)- 3-(4-Hydroxy-3-methoxybenzyl)butane-1,4-diol, the structural formula is as follows:

[0043] .

[0044] This embodiment also provides a preparation method for the above-mentioned lignan compound, which specifically includes the following steps:

[0045](1) Take the lilac stem, add 10 times the amount of 70% (volume concentration) ethanol solution, reflux extraction twice, each time for 2 hours, collect the extract, filter, and concentrate the filtrate under reduced pressure until it has no alcohol smell, and the extract is concentrated liquid;

[0046] (2) Extract the concentrated solution with dichloromethane and ethyl acetate sequentially, the amount of dichloromethane and ethyl acetate is 1 / 3 of the volume of the concentrated solution to obtain the extract of the dichloromethane part and the ethyl acetate part extract;

[0047] (3) Take t...

Embodiment 2

[0051] This embodiment provides a kind of preparation method of the lignan compound in Lilac:

[0052] (1) Take lilac stems, add 20 times the amount of 95% (volume concentration) ethanol solution, cold soak for 3 times, each cold soak for 3 days, collect the extract, filter, and concentrate the filtrate under reduced pressure until it has no alcohol smell. Obtain the extract concentrate;

[0053] (2) Extract the concentrated extract with dichloromethane and ethyl acetate in sequence, the amount of dichloromethane and ethyl acetate each time is 1 / 4 of the volume of the concentrated solution to obtain the extract of the dichloromethane part and the ethyl acetate part extract.

[0054] All the other steps are the same as in Example 1.

Embodiment 3

[0056] This embodiment provides a kind of preparation method of the lignan compound in Lilac:

[0057] (1) Take the lilac stem, add 6 times the amount of 5% (volume concentration) ethanol solution, reflux extraction 3 times, each time for 1 hour, collect the extract, filter, and concentrate the filtrate under reduced pressure until it has no alcohol smell, and the extract is concentrated liquid;

[0058] (2) Extract the concentrated extract with dichloromethane and ethyl acetate in sequence, the amount of dichloromethane and ethyl acetate each time is 1 / 5 of the volume of the concentrated solution to obtain the extract of the dichloromethane part and the ethyl acetate part extract;

[0059] All the other steps are the same as in Example 1.

[0060] 1. Compound structure analysis and identification

[0061] Spectroscopy techniques are mainly used, including ultraviolet, infrared, mass spectrometry, nuclear magnetic resonance ( 1 H-NMR, 13 C-NMR, 2D-NMR) to identify its str...

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Abstract

The invention belongs to the technical field of medicine, and specifically discloses a lignan compound in lilac, a preparation method and application thereof. The name of the compound is 2-(benzo[D][1,3]dioxolane-5-methylene)-3-(4-hydroxy-3-methoxybenzyl)butane-1 ,4‑diol. The preparation method of the lignan compound of the present invention is simple to operate, and the pure compound can be obtained by separation. Experiments have shown that the lignan compound obtained by the present invention can significantly reduce the amount of NO released by LPS-induced BV-2 cells, relieve the inflammation induced by the inflammatory factor LPS, and can prolong the sleep time of mice and significantly reduce the amount of autonomic activity of mice. The number of activities has a good sedative and tranquilizing effect, and can be used as a potential anti-inflammatory, sedative and tranquilizing drug.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a lignan compound in lilac and its preparation method and application. Background technique [0002] Sleep disorder is a common disease, and it is the accompanying symptom of many diseases. Insomnia is the most common sleep disorder, mainly manifested as difficulty in falling asleep and maintaining sleep. Long-term insomnia is easy to cause damage to the patient's psychology and physiology, and seriously affects the quality of life and work of the patient. According to the statistics of the World Health Organization, the global sleep disorder rate reaches 27%. According to the sleep survey results released by the Chinese Sleep Research Association in 2016, the incidence of insomnia among Chinese adults is as high as 38.2%. It can be seen that insomnia has become one of the major global public health problems. At present, the clinical demand for drugs for the trea...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D317/54A61P29/00A61P25/20A61K31/36
CPCC07D317/54A61P29/00A61P25/20
Inventor 冯育林何明珍李志强杨世林李志峰欧阳辉李军茂
Owner JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE