Application of indoleacetic acid (IAA) in preparation of medicine for preventing or treating inflammatory bowel disease

A technology of inflammatory bowel disease and indole acetic acid, applied in the field of medicine, can solve the problems of poor tolerance, unsuitable for long-term use, unsatisfactory long-term efficacy, etc., and achieve the effect of good therapeutic effect

Pending Publication Date: 2022-01-28
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These drugs mainly reduce inflammation by inhibiting abnormal immune response, but they have many disadvantages such as unsatisfactory long-term efficacy, poor tolerance, many side effects, and high price, so they are not suitable for long-term use. Looking for safe, effective and low-cost anti-IBD drugs Has important theoretical significance and clinical application value

Method used

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  • Application of indoleacetic acid (IAA) in preparation of medicine for preventing or treating inflammatory bowel disease
  • Application of indoleacetic acid (IAA) in preparation of medicine for preventing or treating inflammatory bowel disease
  • Application of indoleacetic acid (IAA) in preparation of medicine for preventing or treating inflammatory bowel disease

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Experimental program
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Effect test

Embodiment 1

[0023] This embodiment establishes the following models and performs corresponding drug intervention:

[0024] (1) Animal experiments Using 3% DSS solution to induce C57BL / 6 mice to construct a colitis model (free drinking water DSS aqueous solution for 10 days), and mice were divided into groups, ten in each group, respectively recorded as IAA-IAA treatment group, 5 -ASA-5-aminosalicylic acid treatment group, Colitis-colitis group (use DSS chemical reagent to cause colitis model group), set Ctrl-blank control group (healthy mice without DSS chemical reagent) at the same time;

[0025] (2) Give the model mice IAA (with a dose of 20 mg / kg) or the positive drug 5-ASA (with a dose of 100 mg / kg) by intragastric administration once a day, and record the changes in body weight and DAI scores of the mice every day. See Table 1 for scoring criteria:

[0026] Table 1

[0027]

[0028]

[0029] (3) Collection and analysis of biological samples: the mice were killed on the tenth ...

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Abstract

The invention discloses application of IAA in preparation of a medicine for preventing or treating inflammatory bowel diseases, belonging to the technical field of medicines. Experiments prove that IAA can significantly inhibit the occurrence and development of experimental colitis, effectively relieve colitis related symptoms, relieve weight loss, disease activity index (DAI) up-regulation, colon and spleen swelling and other symptoms of experimental animals caused by colitis, can also obviously regulate the increase of the contents of myeloperoxidase (MPO) and related inflammatory factors (TNF-alpha and IL-1beta) and the reduction of the content of an anti-inflammatory factor (IL-10) in a colitis state, and can restore the integrity of the structure and the function of the intestinal mucosal barrier and correct the imbalance of intestinal homeostasis in an animal body by increasing the expression of intestinal mucosal barrier integrity related proteins (ZO-1 and Occludin), thereby achieving the purpose of preventing and treating inflammatory bowel diseases.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to the application of indole acetic acid (IAA) in the preparation of drugs for preventing or treating inflammatory bowel disease. Background technique [0002] Inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease, is a common clinical chronic digestive system disease that can lead to intestinal mucosal ulceration and progressive destruction of intestinal function. The clinical manifestations of inflammatory bowel disease mainly include abdominal pain, diarrhea, and even bloody stools, which are often protracted and easy to recur, and can induce colon cancer. Ulcerative colitis is a continuous inflammation of the colonic mucosa and submucosa, with lesions concentrated in the colon; Crohn's disease is a discontinuous full-thickness inflammation involving the entire gastrointestinal tract. Over the past decade, IBD has emerged as a global pub...

Claims

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Application Information

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IPC IPC(8): A61K31/405A61P1/00A61P1/04
CPCA61K31/405A61P1/00A61P1/04
Inventor 景王慧王嗣岑包涛董思晶朱敏许银月张梦改
Owner XI AN JIAOTONG UNIV
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