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Constructs targeting labyrinthin or a portion thereof and uses thereof

A technology of constructs and proteins, applied in the direction of non-active ingredient medical preparations, immunoglobulins, anti-enzyme immunoglobulins, etc., can solve problems such as inability to provide sufficient guidance for treatment

Pending Publication Date: 2022-01-28
LABYRX IMMUNOLOGIC THERAPEUTICS(USA)LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is well known that such tissue- or organ-based cancer classifications may not provide sufficient guidance for the selection of effective treatments

Method used

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  • Constructs targeting labyrinthin or a portion thereof and uses thereof
  • Constructs targeting labyrinthin or a portion thereof and uses thereof
  • Constructs targeting labyrinthin or a portion thereof and uses thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0284] This example demonstrates the development and testing of functional single-chain variable fragment (scFv) and antigen-binding fragment (Fab) derived from an anti-labyrin antibody (MCA 44-3A6).

[0285] The heavy chain variable domain (VH) and light chain variable domain (VH) cDNAs of MCA44-3A6 were cloned using oligonucleotide primers available for cDNA synthesis and PCR methods. Clones were based on sequences published in the Immunoglobulin Database. Briefly, with commercially available reagents, from about 5x10 8 RNA prepared by hybridoma cells was used to prepare cDNA. The amplified cDNAs of VH and VL were digested with restriction enzymes whose sites were installed during PCR amplification. The genes were then subcloned into phage display vectors to construct scFvs for library selection purposes.

[0286] The library of scFv is then subcloned. For each scFv, sequences were fused such that upon subsequent expression, the product would have a C-terminal myc tag. ...

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PUM

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Abstract

Constructs comprising an antibody moiety that specifically binds to Labyrinthin or a portion thereof and an effector domain are provided. Also provided are methods of making and using these constructs and compositions thereof.

Description

[0001] Cross References to Related Applications [0002] This application claims priority to U.S. Provisional Patent Application No. 62 / 789,871, filed January 8, 2019, the disclosure of which is hereby incorporated by reference in its entirety. [0003] Submission of sequence listings in ASCII text files [0004] The contents of the following submitted ASCII text file are hereby incorporated by reference in their entirety: Computer Readable Form of the Sequence Listing (CRF) (File Name: 185722000240SEQLIST.TXT, Date of Record: January 7, 2020, Size: 9KB) . technical field [0005] The present application relates to constructs comprising an antibody portion that specifically binds Labyrinthin or a portion thereof and an effector domain. Methods of making and using these constructs and compositions thereof are also provided. Background technique [0006] Historically, the characterization of cancer has been largely based on the tissue type or organ of origin, such as lung, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K16/28C07K16/40A61K35/17
CPCC07K16/30C07K2317/55C07K2317/622C07K2317/92G01N33/57484C12N5/0636A61K35/17C07K16/28C07K16/40C07K16/2809A61P35/00C07K2317/31A61K2039/505C12N2510/00A61K47/68033A61K39/4611A61K2121/00A61K2300/00G01N33/57423G01N33/57492
Inventor M·巴比奇J·A·拉多舍维奇
Owner LABYRX IMMUNOLOGIC THERAPEUTICS(USA)LTD