Application of tripterine in preparation of medicine for inhibiting staphylococcus aureus

Abstract

The invention discloses an application of tripterine in preparation of a medicine for inhibiting staphylococcus aureus. Through homologous modeling and molecular docking, it is found that tripterine can resist methicillin-resistant staphylococcus aureus through P5CDh. On the basis, the minimum inhibitory concentration and the minimum bactericidal concentration of the tripterine on the staphylococcus aureus are measured by utilizing a microdilution method, and the result shows that the tripterine has an exact inhibitory effect on the staphylococcus aureus and can be applied to preparation of drugs or related preparations for inhibiting the staphylococcus aureus.

Description

technical field [0001] The invention relates to a new pharmacological application of tripterine, in particular to the application of tripterine in the preparation of drugs for inhibiting Staphylococcus aureus, and belongs to the field of new pharmacological applications of tripterine. Background technique [0002] Staphylococcus aureus (Staphylococcus aureus) is a common Gram-positive bacterium belonging to the genus Staphylococcus. Under the microscope, it appears as grape clusters, without flagella and spore formation. At present, antibacterial drugs are mainly used to treat Staphylococcus aureus infection clinically, which has led to the emergence of a large number of drug-resistant Staphylococcus aureus. Among them, Methicillin-resistant Staphylococcus aureus (Methicillin-resistant S.aureus, MRSA) is the most notorious. According to reports, MRSA infection has been listed as the world's three most difficult infectious diseases along with HBV infection and AIDS. More th...

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