Application of an ionizable lipid compound in nucleic acid drug delivery system

A nucleic acid drug and delivery system technology, applied in drug delivery, nano-drugs, medical preparations of non-active ingredients, etc., can solve the problems of increased drug dose, increased liver metabolic burden, and low delivery efficiency of the delivery system, reducing the The effect of cumulative side effects
CN114191561BActive Publication Date: 2022-08-02WUHAN BINHUI BIOTECH CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
WUHAN BINHUI BIOTECH CO LTD
Publication Date
2022-08-02

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Abstract

The present invention provides an application of an ionizable lipid compound in a nucleic acid drug delivery system. Most of the existing nucleic acid drug carriers have problems such as low delivery efficiency in vivo or accumulation of toxic and side effects in the liver. In order to solve these problems, the present invention provides a new drug delivery system. The nucleic acid drug delivery system of the present invention is suitable for a variety of administration modes, has little liver toxicity and high nucleic acid delivery efficiency, and can even efficiently deliver nucleic acid drug molecules to the spleen with high specificity and efficiently translate them into target molecules.
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Description

technical field

[0001] The invention belongs to the technical field of nucleic acid drug delivery, in particular to the application of an ionizable lipid compound in a nucleic acid drug delivery system. Background technique

[0002] The active molecules of nucleic acid drugs include messenger RNA (mRNA), small interfering RNA (siRNA), antisense oligonucleotide (ASO) or plasmid DNA (pDNA), which have great potential for application in vaccines and gene therapy in vitro or in vivo . How to successfully deliver nucleic acid drug molecules to in vivo cells and express them efficiently to achieve the purpose of prevention or treatment is one of the urgently needed technologies. Most of the existing nucleic acid drug carriers are prone to accumulate in the liver after entering the body, increase the metabolic burden of the liver, and cause obvious toxic and side effects. In addition, there is a phenomenon that the delivery system is not very efficient, and it is easy to increase...

Claims

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