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Novel molecules for therapy and diagnosis

A technology for binding molecules, synuclein, applied in the field of α-synuclein antibody or its antigen-binding fragment or its derivatives

Pending Publication Date: 2022-03-18
AC IMMUNE SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

To our knowledge, there are currently no approved or clinically available biomarkers for monitoring pathological α-synuclein levels on the market, despite a critical need for Parkinson's disease research and drug development ( Eberling et al., JParkinsons Dis. 2013;3(4):565-7)

Method used

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  • Novel molecules for therapy and diagnosis
  • Novel molecules for therapy and diagnosis
  • Novel molecules for therapy and diagnosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0930] Preparation of α-synuclein liposome vaccine composition

[0931] Liposome-based antigenic constructs were prepared according to the protocol disclosed in WO2012 / 055933. Liposomal vaccine with human full-length α-synuclein as antigen for antibody production (Table 2, SEQ ID NO: 1) or liposomal vaccine with α-synuclein peptide as antigen for antibody production .

[0932] Table 2: Antigen description

[0933]

[0934] mouse immunization

[0935] Female C57BL / 6JOlaHsd and BALB / cOlaHsd mice (Envigo, USA) were vaccinated at 10 weeks of age. The C57BL / 6JOlaHsd substrain is known to have a spontaneous deletion of the α-synuclein gene. Mice were vaccinated with a vaccine in which synthetic monophosphorylhexayl lipid A 3-deacylated (3D-(6-acyl) ) (Avanti Polar Lipids, USA) containing α-synuclein peptide or human full-length α-synuclein present on the surface of liposomes.

[0936] Mice were vaccinated by subcutaneous injection (s.c.) on days 0, 5, 8, 21, 35, 84 and in ...

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Abstract

The present invention relates to novel molecules useful in the prevention, amelioration, treatment and / or diagnosis of diseases, disorders and abnormalities associated with alpha-synuclein (a-synuclein, A-synuclein, a-synuclein, A-syn, alpha-syn, aSyn, a-syn) aggregates, including, but not limited to, Lewy bodies and / or Lewy neurons, such as, but not limited to, Alpha-synuclein, Alpha-synuclein, Alpha-synuclein, Alpha-synuclein, Alpha-synuclein, Alpha-synuclein, Alpha-synuclein, Alpha-synuclein, Alpha-synuclein, Alpha-synuclein, Alpha-synuclein and Alpha-synuclein. For example, Parkinson's disease, multi-system atrophy, dementia with Lewy bodies (LBD; dementia with Lewy bodies (DLB) ('pure 'dementia with Lewy bodies), dementia with Parkinson's disease (PDD) or diffuse Lewy body disease. The present invention relates to alpha-synuclein binding molecules, in particular alpha-synuclein antibodies or antigen binding fragments or derivatives thereof, and uses thereof. The molecules of the invention may also be used to determine the predisposition of predisposition to such a condition, disease, or abnormality, to monitor a residual condition, disease, or abnormality, or to predict the responsiveness of a patient suffering from such a condition, disease, or abnormality to a treatment with a certain drug.

Description

technical field [0001] The present invention relates to can be used for preventing, alleviating, treating and / or diagnosing and alpha-synuclein (alpha-synuclein, A-synuclein, alpha synuclein, A-syn, alpha-syn, aSyn, a-syn) aggregate-associated diseases, disorders, and abnormalities including, but not limited to, Lewy bodies and / or Lewy neurites, such as Parkinson's disease, multiple Systemic atrophy, Lewy Body dementia (LBD; dementia with Lewy body (DLB) ("pure" dementia with Lewy bodies), Parkinson's disease dementia (PDD)), or diffuse Lewy Physical illness. The present invention relates to α-synuclein binding molecules, especially α-synuclein antibodies or antigen-binding fragments or derivatives thereof and uses thereof. The molecules of the invention can also be used to determine a predisposition to such a condition, disease or disorder, to monitor a residual condition, disease or disorder, or to predict the response to a drug in a patient suffering from such a condition...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61P25/28C07K16/18
CPCC07K2317/24C07K16/18C07K2317/34C07K2317/76A61P25/28C07K2317/92G01N33/6896G01N33/582A61K2039/505A61P25/00
Inventor 尔必达·齐卡约翰·瓦尔纳罗曼·克里斯蒂安·奥利耶扬·彼得·亨宁·斯特尔
Owner AC IMMUNE SA
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