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Application of medicine composition in preparation of medicine for treating inflammatory bowel disease

A technology for inflammatory bowel disease and composition, applied in the field of new medical use, can solve the problems of difficult determination of FMT time and dose, and achieve the effect of improving pathological characteristics, definite curative effect, great theoretical value and application prospect

Active Publication Date: 2022-04-12
SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to screen out the alternative pharmaceutical composition for the treatment of IBD from traditional Chinese medicines in order to avoid the side effects of existing drugs for the treatment of IBD and the difficulty in determining the time and dosage of FMT, as well as the risks of exposure to harmful bacterial strains and infection of infectious diseases.

Method used

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  • Application of medicine composition in preparation of medicine for treating inflammatory bowel disease
  • Application of medicine composition in preparation of medicine for treating inflammatory bowel disease
  • Application of medicine composition in preparation of medicine for treating inflammatory bowel disease

Examples

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Embodiment 1-8

[0044] 1 Embodiment 1-8: Preparation of pharmaceutical composition preparation for treating inflammatory bowel disease

Embodiment 1

[0046] This example provides a pharmaceutical composition preparation for treating inflammatory bowel disease. The formula of the raw materials by weight is: 160 parts of pomegranate peel, 140 parts of skullcap, 120 parts of Burnet elm and 120 parts of Cortex Phellodendri.

[0047] The preparation method of the pharmaceutical composition preparation for treating inflammatory bowel disease of the present embodiment comprises the following steps:

[0048] (1) Weigh 160 parts of pomegranate peel and crush it into coarse powder, add 60v / v% ethanol which is 6 times the weight of the pomegranate peel coarse powder for the first time, soak for 0.5h, heat and reflux for extraction for 15min, filter to obtain filtrate, add pomegranate to the filter residue Extract by heating 60v / v% ethanol which is 4 times the weight of the skin powder under reflux for 10min, filter to obtain a filtrate, and combine the two filtrates for later use.

[0049] (2) Weigh 140 parts of Scutellaria baicalens...

Embodiment 2-8

[0054] Examples 2-8 respectively provide a pharmaceutical composition preparation for the treatment of inflammatory bowel disease, the active ingredients of which are extracts of pomegranate peel, scutellaria baicalensis, Burnet burnet and Phellodendron Phellodendri, and the pharmaceutical composition for the treatment of inflammatory bowel disease is prepared The raw material medicine weight part formula of drug preparation is as shown in table 1:

[0055] Table 1

[0056] Example Medicinal raw material formula 2 130 parts of pomegranate peel, 120 parts of skullcap, 100 parts of Burnet, 100 parts of Cortex Phellodendri 3 140 parts of pomegranate peel, 130 parts of skullcap, 110 parts of Burnet, 110 parts of Cortex Phellodendri 4 150 parts of pomegranate peel, 140 parts of skullcap, 120 parts of Burnet, 120 parts of Cortex Phellodendri 5 160 parts of pomegranate peel, 140 parts of skullcap, 120 parts of Burnet, 120 parts of Cortex Phellodendr...

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Abstract

The invention belongs to the technical field of new application of medicines, and particularly discloses application of a pharmaceutical composition in preparation of medicines for treating inflammatory bowel diseases. The medicinal composition comprises the following active pharmaceutical ingredients in parts by weight: 130 to 190 parts of pomegranate bark, 120 to 160 parts of scutellaria baicalensis, 100 to 140 parts of sanguisorba officinalis and 100 to 140 parts of golden cypress. In addition, the pharmaceutical composition for treating the inflammatory bowel disease is further prepared into an enteric-coated granular preparation so as to be more accurately administered. The pharmaceutical composition for treating the inflammatory bowel disease is a pure traditional Chinese medicine preparation, has a good effect of treating the inflammatory bowel disease, is small in dosage, convenient to take, wide in application range, definite in curative effect, safe and reliable, does not depend on drug properties, does not have side effects, and can achieve the effect of treating both symptoms and root causes.

Description

technical field [0001] The invention belongs to the technical field of new application of medicine, and in particular relates to the application of a pharmaceutical composition in the preparation of medicine for treating inflammatory bowel disease. Background technique [0002] Inflammatory bowel disease (Inflammatory bowel disease, IBD) is a recurrent inflammatory disease of the gastrointestinal tract characterized by pain, diarrhea, bloody stool and weight loss, including two main types: Crohn's disease, CD) and ulcerative colitis (Ulcerative colitis, UC). The etiology and pathogenesis of IBD are generally believed to be mainly caused by factors such as environment, genetics, immunity and intestinal flora imbalance. IBD has been listed by the World Health Organization as one of the modern refractory diseases due to its protracted and difficult to heal condition, and even the risk of cancer. At present, single-target drugs such as 5-aminosalicylic acid, glucocorticoids, a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/756A61K9/50A61K47/32A61P1/00A61P1/04A61K36/185A61K36/539A61K36/739
CPCY02A50/30
Inventor 向梅先甘大莉杨素琴
Owner SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES
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