Chinese herbal medicine active matter and vesicle compound with hair nourishing and developing effects as well as preparation method and application of Chinese herbal medicine active matter and vesicle compound

A technology for Chinese herbal medicines and active substances, applied in the field of Chinese herbal medicine actives@vesicle complexes and their preparation, can solve problems such as precipitation, and achieve the effects of improving solubility and dispersibility, improving stability and long-lasting release

Inactive Publication Date: 2022-04-19
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

And it is easily affected by strong electrolytes such as acid, alkali, salt, and even charged Chinese herbal medicine extracts to destroy its vesicle structure and cause precipitation

Method used

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  • Chinese herbal medicine active matter and vesicle compound with hair nourishing and developing effects as well as preparation method and application of Chinese herbal medicine active matter and vesicle compound
  • Chinese herbal medicine active matter and vesicle compound with hair nourishing and developing effects as well as preparation method and application of Chinese herbal medicine active matter and vesicle compound
  • Chinese herbal medicine active matter and vesicle compound with hair nourishing and developing effects as well as preparation method and application of Chinese herbal medicine active matter and vesicle compound

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0071] (1) Weigh Polygonum multiflorum 10g, Senecio 10g, Eclipta 10g, Radix 30g, Atractylodes macrocephala 30g, Alisma 12g, Radix Paeoniae Rubra 30g, Qingpi 12g, Phellodendron 15g, Polygonatum 30g, Zhishouwu 30g, Gynostemma 30g, Mix 30g orientalis leaves, 12g chuanxiong, 12g Gastrodia elata, 10g ebony charcoal, 10g Kochia scoparia, 25g red clover, and 35g donkey-hide gelatin and grind them into powder state.

[0072] (2) Put the Chinese herbal medicine powder in operation (1) into an extraction tank, add 650 mL of water and 800 mL of ethanol for three times, soak for 30 minutes, ethanol precipitation, concentration, and extraction to obtain the Chinese herbal medicine extract. The number of times of extraction is 4 times, the time of each extraction is 4 hours, and the temperature of extraction is 70°C.

[0073] (3) Add 0.3g of glyceryl laurate to the Chinese herbal medicine extract obtained in operation (2), vortex and stir, centrifuge, let stand for 24 hours, filter and conc...

Embodiment 2

[0076] (1) Weigh Polygonum multiflorum 10g, Senecio 10g, Eclipta 10g, Radix 30g, Atractylodes 30g, Alisma 12g, Radix Paeoniae Rubra 30g, Qingpi 12g, Phellodendron 15g, Polygonatum 30g, Zhishouwu 30g, Gynostemma 30g, Mix 30g orientalis leaves, 12g chuanxiong, 12g Gastrodia elata, 10g ebony charcoal, 10g Kochia scoparia, 25g red clover, and 35g donkey-hide gelatin and grind them into powder state.

[0077] (2) Put the Chinese herbal medicine powder in operation (1) into an extraction tank, add 650 mL of water and 800 mL of ethanol for three times, soak for 30 minutes, ethanol precipitation, concentration, and extraction to obtain the Chinese herbal medicine extract. The number of times of extraction is 4 times, the time of each extraction is 4 hours, and the temperature of extraction is 70°C.

[0078] (3) Add 1.5g of monosodium monododecyl phosphate to the Chinese herbal medicine extract obtained in operation (2), vortex and stir, centrifuge, let stand for 24 hours, filter, and ...

Embodiment 3

[0081] (1) Weigh Polygonum multiflorum 10g, Senecio 10g, Eclipta 10g, Radix 30g, Atractylodes 30g, Alisma 12g, Radix Paeoniae Rubra 30g, Qingpi 12g, Phellodendron 15g, Polygonatum 30g, Zhishouwu 30g, Gynostemma 30g, Mix 30g orientalis leaves, 12g chuanxiong, 12g Gastrodia elata, 10g ebony charcoal, 10g Kochia scoparia, 25g red clover, and 35g donkey-hide gelatin and grind them into powder state.

[0082] (2) Put the Chinese herbal medicine powder in operation (1) into an extraction tank, add 650 mL of water and 800 mL of ethanol for three times, soak for 30 minutes, ethanol precipitation, concentration, and extraction to obtain the Chinese herbal medicine extract. The number of times of extraction is 4 times, the time of each extraction is 4 hours, and the temperature of extraction is 70°C.

[0083] (3) Add 0.5g of nicotinic acid to the Chinese herbal medicine extract obtained in operation (2), vortex, centrifuge, let stand for 24 hours, filter and concentrate to obtain the ac...

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Abstract

The invention relates to a Chinese herbal medicine active substance and vesicle compound with hair nourishing and developing effects and a preparation method and application thereof. The compound comprises Chinese herbal medicine active substances and vesicles. The Chinese herbal medicine active matter is coated in the vesicles; the hydrophilic substance is coated in a hydrophilic micro-area, namely in a water core; and the hydrophobic substance is solubilized between the double-layer membrane of the vesicle. According to the Chinese herbal medicine active matter and vesicle compound disclosed by the invention, the Chinese herbal medicine active matter and the vesicle are integrated, and the core-shell double-layer membrane structure of the vesicle can be used for simultaneously solubilizing hydrophilic and hydrophobic active ingredients in the Chinese herbal medicine extract; a stable Chinese herbal medicine active matter and vesicle micro-ecological environment is formed around the scalp and the hair follicles, so that the optimal utilization of the medicine effect is achieved, and the hair nourishing and growing effects are achieved. The invention has the advantages of better permeability, dispersibility and slow release performance, simple process, and good application in the fields of cosmetics and drug delivery and controlled release.

Description

technical field [0001] The invention relates to a Chinese herbal medicine active substance@vesicle complex with the effect of nourishing and hair growth and its preparation, which belongs to the technical field of cosmetics. Background technique [0002] Hair is one of the components of the human body, and changes in hair are closely related to physiological and pathological changes in the human body. Modern people have a fast-paced life, long working hours, high mental stress, and irregular work and rest. Hair loss has gradually become a problem for more and more contemporary people, and it is showing a younger trend. As far as China is concerned, the number of people with hair loss has risen sharply in recent years, and one out of every six people has hair loss. According to statistics, the hair loss rate of the world's population has reached 32.13%, and the number of patients with hair loss is increasing year by year. Hair growth cosmetic products that help with hair gr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/98A61K8/9794A61K8/9789A61K8/9761A61K8/67A61K8/55A61K8/37A61K8/14A61Q5/12A61Q7/00A61P17/14
CPCA61K8/9789A61K8/9794A61K8/9761A61K8/985A61K8/375A61K8/55A61K8/675A61K8/14A61Q7/00A61Q5/12A61P17/14A61K2800/56
Inventor 杜娜陈楠王春省侯万国骆兴伟
Owner SHANDONG UNIV
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