Sihuang heart-fire-clearing pill and preparation method thereof

A technology of Sihuang Qingxin pills and pills, which is applied in pill delivery, pharmaceutical formulations, medical preparations of non-active ingredients, etc., and can solve problems such as slow absorption, large pills, and high operating process costs

Active Publication Date: 2022-05-10
沈阳清宫药业集团有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Sihuang Qingxin Pills prepared by the preparation method of the prior art has the following disadvantages: (1) a large amount of Sihuang Qingxin Pills are used in the preparation process Honey, so it is not suitable for diabetic patients, and the scope of application is limited; (2) The actual drug content is low; (3) The body absorbs slowly after taking it, and the effect is slow; (4) The pellets are large and inconvenient to take; (5) Chinese herbal medicines have a strong smell
However, because the preparation method of this patent involves concentrated extraction, the operating process cost of the required equipment is relatively high, and the relative production cost increases. The above-mentioned problems that the preparation method of pill exists

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0018] A preparation method of Sihuang Qingxin Pills, comprising: (1) raw material pretreatment: artificial bezoar, cork, baicalin, rhubarb, talcum powder, licorice, cinnabar, gardenia, gypsum and borneol are crushed into 80-100 mesh Sieve to obtain the pretreatment powder. In the present application, further, the mass ratio of artificial bezoar, Phellodendri baicalensis, Scutellaria baicalensis, rhubarb, talcum powder, licorice, cinnabar, gardenia, gypsum and borneol is 7.5:201:201:100.5:100.5:100.5:40:67.5: 134:14.

[0019] (2) Binder configuration: Prepare deionized water, adjust the pH of the deionized water to 5.8-6.4, and adjust the temperature to 28-30°C; mix and dissolve κ-carrageenan and konjac gum in deionized water, stir until sticky thick; the mass ratio of deionized water, kappa-carrageenan and konjac gum is 500-580:2-3:1-2.

[0020] Among them, konjac gum and κ-carrageenan are commonly used gelling agents in the food industry, but the former must be at a concen...

Embodiment 1

[0029] This example provides a preparation method of Sihuang Qingxin Pills, including: (1) Raw material pretreatment: 7.5 g of artificial bezoar, 201 g of Phellodendron cortex, 201 g of Scutellaria baicalensis, 100.5 g of rhubarb, 100.5 g of talcum powder, and 100.5 g of licorice , 40 g of cinnabar, 67.5 g of gardenia, 134 g of gypsum, and 14 g of borneol were crushed and passed through an 80-mesh sieve to obtain a pretreatment powder; (2) Binder configuration: prepare deionized water, and adjust the pH of the deionized water to 6.0, adjust the temperature to 29°C; mix and dissolve κ-carrageenan and konjac gum in deionized water, and stir until viscous; the mass ratio of deionized water, κ-carrageenan and konjac gum is 550:2.5:1.5; ( 3) Mold release: Mix cellulose powder, water and binder according to the mass ratio of 1:0.2:0.1 to form a soft material, push through a 25-mesh sieve to obtain granules, repeatedly rotate and hit the granules, and continue to add in multiple times...

Embodiment 2

[0031] This example provides a preparation method of Sihuang Qingxin Pills, including: (1) Raw material pretreatment: 7.5 g of artificial bezoar, 201 g of Phellodendron cortex, 201 g of Scutellaria baicalensis, 100.5 g of rhubarb, 100.5 g of talcum powder, and 100.5 g of licorice , 40 g of cinnabar, 67.5 g of gardenia, 134 g of gypsum and 14 g of borneol were crushed and passed through a 100-mesh sieve to obtain a pretreatment powder; (2) Binder configuration: prepare deionized water, and adjust the pH of the deionized water to 6.0, adjust the temperature to 29°C; mix and dissolve κ-carrageenan and konjac gum in deionized water, and stir until viscous; the mass ratio of deionized water, κ-carrageenan and konjac gum is 550:2.5:1.5; ( 3) Mold release: Mix cellulose powder, water and binder according to the mass ratio of 1:0.3:0.2 to form a soft material, push through a 30-mesh sieve to obtain granules, repeatedly rotate and hit the granules, and continue to add multiple times at ...

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PUM

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Abstract

The invention belongs to the technical field of pharmaceutical preparations, and provides a Sihuang heart-fire-clearing pill and a preparation method thereof. The preparation method comprises the following steps: (1) pretreating raw materials to obtain pretreated medicine powder; (2) binder preparation: preparing a binder from kappa-carrageenan and konjac glucomannan; (3) drawing: drawing by adopting cellulose powder, water and a binder to obtain a mold; and (4) pelleting and covering to obtain the Sihuang heart-fire-clearing pill. By adopting the preparation method, the defects of a large honeyed bolus preparation method can be overcome, the production cost is relatively low, the preparation method is suitable for large-scale production, the prepared product has better comprehensive performance, can be suitable for diabetics to take, can keep higher drug content, and meanwhile, the pill has good roundness, can be quickly absorbed in vivo after being taken, and is suitable for clinical application. The pill is small in size, convenient to take and small in smell of traditional Chinese medicinal materials.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a Sihuang Qingxin Pill and a preparation method thereof. Background technique [0002] Sihuang Qingxin Pills can be used for febrile diseases with high fever, qi and blood burnt due to its functions of clearing away heart-fire, relieving heat, resuscitating the mind and awakening the mind. The specific composition and preparation method of Sihuang Qingxin Pills are recorded in the "National Compilation of Standards of Chinese Patent Medicine Meridian, Limbs and Brain Systems, Page Number: GJN-246". The raw materials of Sihuang Qingxin Pills include artificial bezoar, phellodendron, scutellaria baicalensis, rhubarb, talc, licorice, cinnabar, gardenia, gypsum, borneol, and honey. The finished product is brown to tan large honeyed pills, with the aroma of borneol, and the taste is slightly sweet at first, and then slightly bitter. [0003] The Sihua...

Claims

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Application Information

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IPC IPC(8): A61K36/756A61K9/20A61K47/38A61K47/36A61P29/00A61P1/02A61P25/00A61P1/10A61K35/413A61K33/12A61K33/28A61K33/06A61K31/045
CPCA61K35/413A61K36/756A61K36/539A61K36/708A61K33/12A61K36/484A61K33/28A61K36/744A61K33/06A61K31/045A61K9/2054A61K9/205A61P29/00A61P1/02A61P25/00A61P1/10A61K2300/00Y02A50/30
Inventor 耿福能林庆华沈咏梅耿越飞
Owner 沈阳清宫药业集团有限公司
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