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Bacteria comprising myo-inositol to propionic acid pathway

A technology of bacteria and inositol, applied in the field of prevention and/or treatment of metabolic diseases, can solve problems such as unclear mechanism of occurrence

Pending Publication Date: 2022-05-13
WAGENINGEN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] However, although dietary supplementation of inositol is known to reduce insulin resistance, the mechanism by which this phenomenon occurs remains unclear

Method used

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  • Bacteria comprising myo-inositol to propionic acid pathway
  • Bacteria comprising myo-inositol to propionic acid pathway
  • Bacteria comprising myo-inositol to propionic acid pathway

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Embodiment Construction

[0012] The present disclosure relates to a bacterium comprising a gene set encoding the inositol to propionate pathway, which allows the bacterium to convert inositol into propionate or a salt or ester thereof for the prevention and / or treatment of metabolic syndrome, insulin resistance and / or insulin resistance-related conditions.

[0013] Specifically, the bacterium is capable of converting inositol to propionic acid or its derivatives through inositol metabolism and propionic acid synthesis. The inositol may be chiro-inositol or myo-inositol, preferably myo-inositol. In a preferred embodiment, the bacterium is also a butyrogenic (butyrogenic) bacterium that produces butyrate and / or butyrate (salt / ester) (i.e. also contains butyrate / butyrate synthesis pathway genes set).

[0014] Without wishing to be bound by theory, it is believed that bacteria according to the present disclosure (or strains derived therefrom), when administered to or ingested in sufficient quantities by...

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Abstract

The present invention relates to a bacterium comprising an inositol-to-propionic acid pathway gene set that allows the bacterium to convert inositol to propionic acid or a salt or ester thereof. The bacteria are useful as probiotics or supplements to promote the production of propionic acid in the gastrointestinal tract, thereby preventing and / or treating conditions or diseases that benefit from the production of propionic acid, such as metabolic diseases, metabolic syndromes, insulin resistance or insulin resistance-related conditions, in particular insulin resistance of dyslipidemia, type 2 diabetes and endocrine diseases.

Description

technical field [0001] The present invention relates to the field of prevention and / or treatment of metabolic diseases, such as metabolic syndrome and insulin resistance or insulin resistance-related conditions, including dyslipidemia and type 2 diabetes and endocrine diseases (for example, people with type 1 diabetes, Cushing's disease or fat Insulin resistance in obese subjects with lipodystrophy syndrome). Background technique [0002] Insulin resistance is a medical condition in which cells become resistant to insulin, resulting in high blood sugar levels. People with type 2 diabetes often already experience the early stages of insulin resistance, although this early stage is often undiagnosed. [0003] Dietary supplementation with myo-inositol has been found to be effective in reducing postprandial plasma glucose in several animal models of diabetes or insulin resistance (Ortmeyer et al 1993 Endocrinology 132:646-651; Ortmeyer et al 1995 Obesity Research 3:605S-608S; C...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N1/21C12N15/53C12N15/60C12N15/55C12N15/61C12N15/54A23C9/12A61K35/74A61P3/06A61P3/10A61P5/50C12R1/01
CPCC12Y101/01018C12Y402/01044C12Y307/01C12Y503/01C12Y207/01092C12Y401/02029C12Y503/01001C12Y102/01012C12Y207/02003C12Y504/02001C12Y402/01011C12Y102/07C12Y208/03008C12Y103/08001C12Y402/01055C12Y503/99C12Y101/01027C12Y101/01001C12Y102/0101C12Y207/0104C12N9/0006C12N9/0008C12N9/88C12N9/90C12N9/14C12N9/1205C12N9/1217C12N9/13C12N9/001A23C9/12A61K35/74A61P3/06A61P3/10A61P5/50A61K31/047C12N15/52C12P7/52C12N1/205C12R2001/01C12R2001/19A61K2300/00A61K35/742
Inventor W·M·德沃斯T·P·N·布
Owner WAGENINGEN UNIV
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