Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Bacteria comprising myo-inositol to propionic acid pathway

A technology of bacteria and inositol, applied in the field of prevention and/or treatment of metabolic diseases, can solve problems such as unclear mechanism of occurrence

Pending Publication Date: 2022-05-13
WAGENINGEN UNIV
View PDF3 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, although dietary supplementation of inositol is known to reduce insulin resistance, the mechanism by which this phenomenon occurs remains unclear

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Bacteria comprising myo-inositol to propionic acid pathway
  • Bacteria comprising myo-inositol to propionic acid pathway
  • Bacteria comprising myo-inositol to propionic acid pathway

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0012] The present disclosure relates to a bacterium comprising a gene set encoding the inositol to propionate pathway, which allows the bacterium to convert inositol into propionate or a salt or ester thereof for the prevention and / or treatment of metabolic syndrome, insulin resistance and / or insulin resistance-related conditions.

[0013] Specifically, the bacterium is capable of converting inositol to propionic acid or its derivatives through inositol metabolism and propionic acid synthesis. The inositol may be chiro-inositol or myo-inositol, preferably myo-inositol. In a preferred embodiment, the bacterium is also a butyrogenic (butyrogenic) bacterium that produces butyrate and / or butyrate (salt / ester) (i.e. also contains butyrate / butyrate synthesis pathway genes set).

[0014] Without wishing to be bound by theory, it is believed that bacteria according to the present disclosure (or strains derived therefrom), when administered to or ingested in sufficient quantities by...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention relates to a bacterium comprising an inositol-to-propionic acid pathway gene set that allows the bacterium to convert inositol to propionic acid or a salt or ester thereof. The bacteria are useful as probiotics or supplements to promote the production of propionic acid in the gastrointestinal tract, thereby preventing and / or treating conditions or diseases that benefit from the production of propionic acid, such as metabolic diseases, metabolic syndromes, insulin resistance or insulin resistance-related conditions, in particular insulin resistance of dyslipidemia, type 2 diabetes and endocrine diseases.

Description

technical field [0001] The present invention relates to the field of prevention and / or treatment of metabolic diseases, such as metabolic syndrome and insulin resistance or insulin resistance-related conditions, including dyslipidemia and type 2 diabetes and endocrine diseases (for example, people with type 1 diabetes, Cushing's disease or fat Insulin resistance in obese subjects with lipodystrophy syndrome). Background technique [0002] Insulin resistance is a medical condition in which cells become resistant to insulin, resulting in high blood sugar levels. People with type 2 diabetes often already experience the early stages of insulin resistance, although this early stage is often undiagnosed. [0003] Dietary supplementation with myo-inositol has been found to be effective in reducing postprandial plasma glucose in several animal models of diabetes or insulin resistance (Ortmeyer et al 1993 Endocrinology 132:646-651; Ortmeyer et al 1995 Obesity Research 3:605S-608S; C...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C12N1/21C12N15/53C12N15/60C12N15/55C12N15/61C12N15/54A23C9/12A61K35/74A61P3/06A61P3/10A61P5/50C12R1/01
CPCC12Y101/01018C12Y402/01044C12Y307/01C12Y503/01C12Y207/01092C12Y401/02029C12Y503/01001C12Y102/01012C12Y207/02003C12Y504/02001C12Y402/01011C12Y102/07C12Y208/03008C12Y103/08001C12Y402/01055C12Y503/99C12Y101/01027C12Y101/01001C12Y102/0101C12Y207/0104C12N9/0006C12N9/0008C12N9/88C12N9/90C12N9/14C12N9/1205C12N9/1217C12N9/13C12N9/001A23C9/12A61K35/74A61P3/06A61P3/10A61P5/50A61K31/047C12N15/52C12P7/52C12N1/205C12R2001/01C12R2001/19A61K2300/00A61K35/742
Inventor W·M·德沃斯T·P·N·布
Owner WAGENINGEN UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com