Traditional Chinese medicine composition for treating diabetes and preparation method thereof

A technology of composition and compound, which is applied in the field of traditional Chinese medicine, can solve the problems of further improvement of the effect, poor utilization of medicinal material resources, and low utilization rate of medicinal materials, and achieve obvious synergy, improved color and taste, and increased bioavailability Effect

Pending Publication Date: 2022-05-31
ZHEJIANG XINCHANG NATURAL HEALTH PROD CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] The above-mentioned methods all have a certain hypoglycemic effect, but either the medicinal taste is too much, or the utilization of clinical deployment and medicinal resources is poor, the utilization rate of the medicinal materials is low, and the maximum efficacy of the medicinal materials has not been exerted. Compared with chemical medicines, The effect needs to be further improved

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  • Traditional Chinese medicine composition for treating diabetes and preparation method thereof
  • Traditional Chinese medicine composition for treating diabetes and preparation method thereof
  • Traditional Chinese medicine composition for treating diabetes and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] The proportion of raw materials in this example is as follows: 120 parts of bitter gourd, 80 parts of mulberry leaves, 85 parts of American ginseng, 8 parts of propolis, and 0.022 parts of chromium picolinate.

[0052] The preparation method of the present embodiment is as follows:

[0053] (1) pulverize bitter gourd and American ginseng, add 5 times of water to soak for 30min, then add cellulase and bromelain for enzymolysis to obtain enzymolysis solution, and filter to obtain medicinal residue 1;

[0054] The mass ratio of cellulase and bromelain is 1:6, the temperature of the enzymatic hydrolysis is 30° C., the pH of the enzymatic hydrolysis is 5.5, and the time of the enzymatic hydrolysis is 1 h.

[0055] (2) Mixing medicinal residue 1 and 87.5% mulberry leaves, adding 80% ethanol and refluxing for 2 hours to obtain alcohol extract and medicinal residue 2; Concentrating the alcohol extract to a relative density of 1.2 (at 60°C), the concentrated solution was first ...

Embodiment 2

[0062] The proportion of raw materials in this example is as follows: 130 parts of bitter gourd, 90 parts of mulberry leaves, 100 parts of American ginseng, 15 parts of propolis, and 0.03 part of chromium picolinate.

[0063] The preparation method of the present embodiment is as follows:

[0064] (1) pulverize bitter gourd and American ginseng, add 5 times the amount of water to soak for 10 minutes, then add cellulase and bromelain for enzymatic hydrolysis to obtain enzymatic hydrolysis solution, and filter to obtain medicinal residue 1;

[0065] The mass ratio of cellulase and bromelain is 1:10, the temperature of the enzymatic hydrolysis is 40° C., the pH of the enzymatic hydrolysis is 6.5, and the time of the enzymatic hydrolysis is 2 h.

[0066] (2) Mixing medicinal residue 1 and 85% mulberry leaves, adding 75% ethanol and refluxing for 1 hour to obtain alcohol extract and medicinal residue 2; Concentrating the alcohol extract to a relative density of 1.2 (at 60°C), the c...

Embodiment 3

[0073] The proportion of raw materials in this example is as follows: 100 parts of bitter gourd, 60 parts of mulberry leaves, 75 parts of American ginseng, 5 parts of propolis, and 0.01 part of chromium picolinate.

[0074] The preparation method of the present embodiment is as follows:

[0075] (1) pulverize bitter gourd and American ginseng, add 5 times the amount of water to soak, then add cellulase and bromelain for enzymatic hydrolysis to obtain enzymatic hydrolysis solution, and filter to obtain medicinal residue 1;

[0076] The mass ratio of cellulase to bromelain is 1:8, the temperature of the enzymatic hydrolysis is 40° C., the pH of the enzymatic hydrolysis is 6.5, and the time of the enzymatic hydrolysis is 2 h.

[0077] (2) Mixing medicinal residue 1 and 87.5% mulberry leaves, adding 80% ethanol and refluxing for 1 hour to obtain alcohol extract and medicinal residue 2; Concentrating the alcohol extract to a relative density of 1.2 (at 60°C), the concentrated solut...

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Abstract

The invention belongs to the field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating diabetes and a preparation method thereof. The composition is prepared from the following raw materials: 100 to 140 parts of bitter gourd, 50 to 90 parts of folium mori, 70 to 100 parts of American ginseng, 5 to 15 parts of propolis and 0.01 to 0.05 part of chromium picolinate. The preparation method comprises the following steps: firstly, carrying out enzymolysis on bitter gourd and American ginseng, concentrating to obtain enzymatic hydrolysate, and filtering to obtain decoction dregs 1; then carrying out mixed alcohol purification and water extraction on the medicine residue 1 and part of mulberry leaves to obtain eluent and polysaccharide; and stirring the dry paste powder of the enzymatic hydrolysate and the eluent with lecithin and sucrose ester to obtain a compound, mixing the compound with polysaccharide, adding the remaining mulberry leaf powder, propolis and chromium picolinate, and mixing to obtain the mulberry leaf extract. The composition prepared by the invention is good in hypoglycemic effect, high in medicinal material utilization rate, free of toxic and side effects on liver and kidney and good in application prospect.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition for treating diabetes and a preparation method thereof. Background technique [0002] Diabetes mellitus is an endocrine and metabolic syndrome characterized by disorders of glucose metabolism. It is caused by relative or absolute insufficiency of insulin, or a deficiency in the utilization of insulin. and chronic complications of tissues and organs such as heart disease. [0003] Western medicines for the treatment of diabetes mainly include the following categories: [0004] ①Biguanide: Biguanide hypoglycemic drugs are such drugs mainly by inhibiting the intestinal recycling of glucose and promoting the decomposition of glucose in the tissue to lower blood sugar, so as to achieve the purpose of treating diabetes, representative drugs include metformin, phenformin, etc. ; [0005] ②Sulfonylureas: mainly by promot...

Claims

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Application Information

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IPC IPC(8): A61K36/605A61P3/10B01D11/02B01D36/00A61K31/555A61K35/644
CPCA61K36/42A61K36/605A61K36/258A61K35/644A61K31/555A61P3/10B01D11/02B01D11/0288B01D36/008A61K2236/19A61K2236/333A61K2236/39A61K2236/53A61K2236/51A61K2236/55A61K2300/00
Inventor孙载明孙思南
OwnerZHEJIANG XINCHANG NATURAL HEALTH PROD CO LTD