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Targeting molecular probe for non-invasive evaluation of sentinel lymph node metastasis of breast cancer

A technology of sentinel lymph nodes and targeting molecules, which is applied in the medical field, can solve the problems of lack of targeting of nanoprobes, and achieve the effects of assisting axillary lymph node staging, improving prognosis, and large spatial resolution of imaging

Pending Publication Date: 2022-06-24
厦门大学附属翔安医院 +1
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, simple nanoprobes lack targeting, and it is difficult to accurately locate tumors only by relying on the EPR effect.

Method used

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  • Targeting molecular probe for non-invasive evaluation of sentinel lymph node metastasis of breast cancer
  • Targeting molecular probe for non-invasive evaluation of sentinel lymph node metastasis of breast cancer
  • Targeting molecular probe for non-invasive evaluation of sentinel lymph node metastasis of breast cancer

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preparation example Construction

[0042] The synthetic method of targeting molecular probe ErNPs@POL6326 according to the embodiment of the present invention includes the following steps:

[0043] 1) Synthesis of NaErF by high temperature co-precipitation synthesis 4 nuclear

[0044] Take a three-necked flask, add 3-8 mL of oleic acid (OA) and 10-15 mL of octadecene (ODE), and then add Er (CH3COO) 3 (1mmol, 0.3444g) mixed and stirred, and vacuumed at room temperature; the temperature was raised to 110~150°C, and the reaction was carried out until the liquid was clear without solid particles; cooled to 40~60°C; 0.7~0.9M ammonium fluoride methanol solution, 0.4~ 5mL each of 0.6M sodium hydroxide methanol solution, react at 40~60℃ for 20-30min; open the glass stopper of the three-necked flask, heat up to 100~150℃, completely remove methanol; 2 , 3 times; heat up to 280~320℃, react for 1.5~2h; cool to room temperature, add excess ethanol, centrifuge at 6000~8000rpm, 5~15min; discard the supernatant, add cyclohex...

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Abstract

The invention discloses a targeting molecular probe for non-invasive evaluation of breast cancer sentinel lymph node metastasis, and relates to the technical field of medicine. Rare earth nanoparticles NaErF4 are used as an inner core, NaYF4 covers the surface of the inner core, rare earth core-shell nanoparticles NaErF4-coated NaYF4 (ErNPs) are synthesized, the outer surface of the NaYF4 layer is modified with PAA to provide carboxyl, the carboxyl is activated through EDC / NHS, and CXCR4-targeted tumor specific guide peptide Balixazotide (POL6326) is coupled, so that the NIR-IIb luminous rare earth nanoprobe ErNPs-coated POL6326 is synthesized. Whether breast cancer sentinel node metastasis exists or not is judged based on near-infrared two-b region imaging, the sentinel node metastasis state is judged in real time in a non-invasive mode before an operation, excessive biopsy is avoided, axillary lymph node staging in the operation is assisted, the life quality of a patient is improved, and the method has important clinical significance on improvement of prognosis of the patient.

Description

technical field [0001] The invention relates to the field of medical technology, in particular to a targeted molecular probe for non-invasive assessment of sentinel lymph node metastasis of breast cancer. Background technique [0002] Breast cancer is the malignant tumor with the highest incidence in the world, which seriously affects the physical and mental health of women. Sentinel lymph node biopsy (SLNB) is the main method for axillary staging of early breast cancer. Sentinel lymph node (SLN) needs to be removed for pathological examination to determine whether metastasis. However, SLNB may cause sequelae such as lymphedema and arm numbness, and studies have shown that about 70% of SLNB patients have no metastasis, so SLNB should be avoided. Currently commonly used lymph node tracers such as methylene blue and ICG can only play a tracer role, and the assessment of lymph node metastasis still needs to rely on pathological biopsy. How to non-invasively assess SLN metasta...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/00
CPCA61K49/0019A61K49/0056A61K49/0093
Inventor 张国君朱媛媛张云宋良张永渠黄文河刘婉玲
Owner 厦门大学附属翔安医院
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