Desorption electrospray ionization mass spectrometry system and mass spectrometry detection method

A technology of electrospray ionization and electrospray ionization source, which is applied in the field of desorption electrospray ionization mass spectrometry equipment to achieve the effects of reducing blooming, reducing contact area and high resolution

Pending Publication Date: 2022-06-24
UNIV OF SCI & TECH OF CHINA
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] Aiming at the existing technical problems, the present invention provides a desorption electrospray ionization mass spectrometry system and a mass spectrometry detection method for at least partially solving the above technical problems

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  • Desorption electrospray ionization mass spectrometry system and mass spectrometry detection method
  • Desorption electrospray ionization mass spectrometry system and mass spectrometry detection method
  • Desorption electrospray ionization mass spectrometry system and mass spectrometry detection method

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Embodiment Construction

[0037] In order to make the objectives, technical solutions and advantages of the present invention more clearly understood, the present invention will be further described in detail below in conjunction with specific embodiments and with reference to the accompanying drawings.

[0038] The terminology used herein is for the purpose of describing particular embodiments only and is not intended to limit the present disclosure. The terms "comprising", "comprising" and the like used herein indicate the presence of stated features, steps, operations and / or components, but do not preclude the presence or addition of one or more other features, steps, operations or components.

[0039] All terms including technical and scientific terms used herein have the meanings commonly understood by those skilled in the art unless otherwise defined. It should be noted that the terms used herein should be construed to have meanings consistent with the context of the present specification and sho...

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Abstract

The present disclosure provides a desorption electrospray ionization mass spectrometry system, comprising: a translation assembly configured to translate in a horizontal direction and suitable for placing a sample to be subjected to mass spectrometry detection; the desorption electrospray ion source comprises a spray needle and is suitable for spraying ions to the sample; the flow guide plate is arranged between the translation assembly and the spray needle, a flow guide hole is formed in the flow guide plate, and the flow guide hole is located in the range of ion spray formed by ions sprayed by the spray needle and is suitable for intercepting part of ions and guiding the other part of ions to the projection position, opposite to the flow guide hole, of the sample. The invention also provides a mass spectrometry method which comprises the following steps: adjusting the relative positions of the flow guide plate, the spray needle and the translation assembly, and keeping the flow guide hole at a target position; and controlling the mass spectrometer, the translation assembly and the flow valve to periodically start according to the time sequence signal, so as to gradually sample the sample until the mass spectrometric detection of the sample is completed.

Description

technical field [0001] At least one embodiment of the present disclosure relates to a desorption electrospray ionization mass spectrometry device, and in particular, to a desorption electrospray ionization mass spectrometry system and a mass spectrometry detection method. Background technique [0002] Mass spectrometry imaging technology based on focused ion and laser technology has high imaging resolution and can form relatively fine spatial resolution information of biomolecules. [0003] At present, an open analytical electrospray ionization mass spectrometer system generally includes a desorption electrospray ionization source (DESI), a mobile platform and a mass spectrometer. During the mass spectrometry process, the desorption electrospray ionization source ejects ions in the form of charged droplets. The spray is formed on the surface of the sample and imaged by a mass spectrometer. [0004] In the mass spectrometry process, due to the large contact area between the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/68
CPCG01N27/68
Inventor 黄光明侯壮豪
Owner UNIV OF SCI & TECH OF CHINA
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