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Composition with antioxidant, moisturizing and lubricating effects and application thereof

A technology of lubricating effect and composition, applied in the field of medical devices, can solve the problems of ineffective removal of free radicals in the eye, eye irritation, insufficient lubricating and moisturizing effect, etc., so as to relieve eye fatigue and discomfort, improve wearing comfort, protect eye effect

Pending Publication Date: 2022-07-15
深圳中科欣扬生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved by the present invention is that the existing lubricating liquid and artificial tears have the defects of eye irritation, insufficient lubricating and moisturizing effect, and inability to effectively remove free radicals in the eyes

Method used

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  • Composition with antioxidant, moisturizing and lubricating effects and application thereof
  • Composition with antioxidant, moisturizing and lubricating effects and application thereof
  • Composition with antioxidant, moisturizing and lubricating effects and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] (1) Weigh ectoine 1%, collagen 0.1%, ergothioneine 0.02%, humectant sodium hyaluronate 0.1%, surfactant poloxamer-407 0.1%, chelating agent EDTA-2Na 0.05 %, borate buffer 0.01-10%, osmotic pressure regulator NaCl 0.01-2% and water for injection;

[0040] (2) dissolve the borate buffer weighed in step (1) in water for injection to obtain solution A, and adjust the pH to 6.5-7.5;

[0041] (3) the sodium hyaluronate, poloxamer-407, EDTA-2Na and 80% solution A that were weighed in step (1) were continuously stirred at 60°C until completely dissolved to prepare solution B, which was cooled to room temperature;

[0042](4) ectoine, collagen and ergothioneine taken by step (1) are dissolved in remaining solution A to complete dissolution to obtain solution C;

[0043] (5) Mix solution B and solution C evenly, add the NaCl weighed in step (1) to adjust the osmotic pressure to 300mOsm / (Kg·H 2 0), carry out filtration sterilization, subpackage, and get final product.

Embodiment 2

[0045] (1) Weigh ectoine 2%, collagen 0.01%, ergothioneine 0.05%, sodium hyaluronate 0.1%, poloxamer-407 0.1%, EDTA-2Na 0.05%, borate buffer 0.01~10%, NaCl 0.01~2% and water for injection;

[0046] (2) dissolve the borate buffer weighed in step (1) in water for injection to obtain solution A, and adjust the pH to 6.5-7.5;

[0047] (3) the sodium hyaluronate, poloxamer-407, EDTA-2Na and 80% solution A that were weighed in step (1) were continuously stirred at 60 ° C until completely dissolved to prepare solution B, which was cooled to room temperature;

[0048] (4) Dissolving the ectoine, collagen and ergothioneine weighed in step (1) in the remaining solution A to complete dissolution to obtain solution C.

[0049] (5) Mix solution B and solution C evenly, add the NaCl weighed in step (1) to adjust the osmotic pressure to 300mOsm / (Kg·H 2 0), carry out filtration sterilization, subpackage, and get final product.

Embodiment 3

[0051] (1) Weigh ectoine 0.5%, collagen 0.3%, ergothioneine 0.2%, sodium hyaluronate 0.1%, poloxamer-407 0.1%, EDTA-2Na 0.05%, borate buffer 0.01-10%, NaCl 0.01-2% and water for injection. ;

[0052] (2) dissolve the borate buffer weighed in step (1) in water for injection to obtain solution A, and adjust the pH to 6.5-7.5;

[0053] (3) the sodium hyaluronate, poloxamer-407, EDTA-2Na and 80% solution A that were weighed in step (1) were continuously stirred at 60 ° C until completely dissolved to prepare solution B, which was cooled to room temperature;

[0054] (4) Dissolving the ectoine, collagen and ergothioneine weighed in step (1) in the remaining solution A to complete dissolution to obtain solution C.

[0055] (5) Mix solution B and solution C evenly, add the NaCl weighed in step (1) to adjust the osmotic pressure to 300mOsm / (Kg·H 2 0), carry out filtration sterilization, subpackage, and get final product.

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Abstract

The invention discloses a composition with antioxidant, moisturizing and lubricating effects and application of the composition, and belongs to the field of medical instruments. The invention provides an antioxidant moisturizing and lubricating composition containing Ectoine, collagen and ergothioneine. The antioxidant moisturizing and lubricating composition is prepared from the following components in percentage by mass: 0.01%-1% of collagen, 0.1%-5% of Ectoine, 0.005%-0.1% of ergothioneine, 0.01%-1% of a moisturizing agent, 0.01%-10% of a buffering agent, 0.01%-2% of an osmotic pressure regulator, 0.001%-5% of a surfactant and 0.05%-5% of a chelating agent. The moisturizing eye composition provided by the invention not only can be used as a lubricating liquid when contact lenses are worn, but also can be used as eye drops for relieving dry and uncomfortable eyes and the like, and the Ectoine and the ergothioneine in the composition also have a sterilization effect, so that the composition disclosed by the invention does not contain preservatives and bactericides.

Description

technical field [0001] The invention belongs to the field of medical devices, and in particular relates to a composition with anti-oxidative, moisturizing and lubricating effects and applications thereof. Background technique [0002] With the popularization and application of display terminals, computers have become indispensable office equipment for daily office work, and mobile phones have also become something we carry around in our lives. In recent years, people have been using computers and mobile phones for more and more time, resulting in eye resistance The oxidative defense system is weakened, causing vision loss, blurred vision and other eye diseases. According to the previous research report of the World Health Organization, the number of myopia patients in China is as high as 600 million, and the rate of myopia among adolescents ranks first in the world. In addition, the number of patients with astigmatism, hyperopia and refractive error is also increasing year b...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/39A61P27/02A61P39/06A61P29/00A61P27/04A61K31/505A61K31/4172A61K31/728
CPCA61K31/505A61K38/39A61K31/4172A61K31/728A61K9/0048A61P27/02A61P39/06A61P29/00A61P27/04A61K2300/00
Inventor 丁利平张山董亮秦丽娜
Owner 深圳中科欣扬生物科技有限公司
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