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Oral care products and methods of use and preparation thereof

A technology for oral care and oral cavity, which is applied in skin care preparations, oral care, cosmetic preparations, etc., and can solve problems such as promoting calcium ions, increasing pH, and stimulating

Pending Publication Date: 2022-07-15
COLGATE PALMOLIVE CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, there was previous concern that basic amino acids could raise the pH and facilitate the dissociation of calcium ions, which could react with fluoride ions to form insoluble precipitates
Also, higher pH may cause irritation

Method used

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  • Oral care products and methods of use and preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0431] Example 1 - Formulation

[0432] Table 1 below lists representative oral care formulations of the present invention. Specifically, the formulations indicate representative toothpaste formulations.

[0433] Table 1.

[0434]

example 2

[0436] The ability of the combination of xylitol and arginine to inhibit the growth of Streptococcus mutans was tested in culture. The percent growth inhibition was measured 24 hours after application of the neat solutions listed in the table below. Percent growth inhibition was measured relative to a control solution without arginine and / or xylitol.

[0437] Table 2 (wt%) (% growth inhibition relative to control)

[0438] 1.5% Arginine 4.1％ 1% Xylitol 17.9％ 5% Xylitol 40.3％ 10% Xylitol 45.6％ 1% Xylitol and 1.5% Arginine 24.2％ 5% Xylitol and 1.5% Arginine 37.2％ 10% Xylitol and 1.5% Arginine 43.5％

[0439] The results in Table 2 were obtained without the addition of sucrose.

[0440] Determination of Minimum Inhibitory Concentration (MIC) of xylitol: In a separate experiment, simple solutions with only different concentrations of xylitol tested in combination with controls were also tested to determine inhibition of planktoni...

example 3

[0447] There may be a relatively significant reduction in pH of S. mutans biofilms. Such pH reductions can be detrimental to oral health. However, cells in culture were unexpectedly protected from these pH decreases after exposure to certain combinations of arginine and xylitol for 24 hours with the addition of growth medium. Notably and unexpectedly, the combination of 1.5 wt% arginine with 5 wt% or 10 wt% xylitol caused the greatest improvement in preventing pH reduction, which is glycolysis by S. mutans active function. Table 5 illustrates that the combination of 1.5% arginine with 5% or 10% xylitol showed improvement compared to solution cells with arginine or xylitol alone.

[0448] table 5

[0449] Table 5 (wt%) (total AUC of ΔpH)

[0450] Control (without arginine or xylitol) 29.5 1.5% Arginine 28.9; Δ (relative to control) = 0.6 1% Xylitol 27.8; Δ (relative to control) = 1.7 5% Xylitol 25.3; Δ (relative to control) = 4.2 10% Xyl...

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Abstract

The present invention relates to an oral care composition comprising a basic amino acid or salt thereof, a sugar alcohol, and optionally a fluoride source wherein the oral care composition is in an amount effective to inhibit a reduction in pH in the oral cavity due to bacterial glycolysis; and methods of using and making these compositions.

Description

[0001] CROSS-REFERENCE TO RELATED APPLICATIONS [0002] This application claims the benefit of and priority to US Provisional Application 62 / 944,696, filed December 06, 2019, the contents of which are incorporated herein by reference in their entirety. technical field [0003] The present invention relates to oral care compositions comprising sugar alcohols and basic amino acids or salts thereof, and optionally a source of fluoride, and methods of using and making these compositions. Background technique [0004] When used in oral care compositions, arginine and other basic amino acids are believed to have significant benefits in combating cavity formation and tooth sensitivity. However, combining these basic amino acids with minerals with oral care benefits such as fluoride and calcium to form oral care products with acceptable long-term stability has proven challenging. Various formulation problems exist with the use of amino acids in oral care compositions. For example,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/34A61K8/44A61Q11/00A61Q17/00
CPCA61K8/345A61Q11/00A61K8/44A61Q17/005A61P1/02A61P31/04A61K31/045A61K31/198A61K2800/59
Inventor 斯泰西·拉文德卢恰娜·林奥迪马龙徐云埃林·拉斯科夫斯基希拉·皮尔希佐耶·斯库尔洛斯
Owner COLGATE PALMOLIVE CO
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