Oral care products and methods of use and preparation thereof
A technology for oral care and oral cavity, which is applied in skin care preparations, oral care, cosmetic preparations, etc., and can solve problems such as promoting calcium ions, increasing pH, and stimulating
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example 1
[0431] Example 1 - Formulation
[0432] Table 1 below lists representative oral care formulations of the present invention. Specifically, the formulations indicate representative toothpaste formulations.
[0433] Table 1.
[0434]
example 2
[0436] The ability of the combination of xylitol and arginine to inhibit the growth of Streptococcus mutans was tested in culture. The percent growth inhibition was measured 24 hours after application of the neat solutions listed in the table below. Percent growth inhibition was measured relative to a control solution without arginine and / or xylitol.
[0437] Table 2 (wt%) (% growth inhibition relative to control)
[0438] 1.5% Arginine 4.1％ 1% Xylitol 17.9％ 5% Xylitol 40.3％ 10% Xylitol 45.6％ 1% Xylitol and 1.5% Arginine 24.2％ 5% Xylitol and 1.5% Arginine 37.2％ 10% Xylitol and 1.5% Arginine 43.5％
[0439] The results in Table 2 were obtained without the addition of sucrose.
[0440] Determination of Minimum Inhibitory Concentration (MIC) of xylitol: In a separate experiment, simple solutions with only different concentrations of xylitol tested in combination with controls were also tested to determine inhibition of planktoni...
example 3
[0447] There may be a relatively significant reduction in pH of S. mutans biofilms. Such pH reductions can be detrimental to oral health. However, cells in culture were unexpectedly protected from these pH decreases after exposure to certain combinations of arginine and xylitol for 24 hours with the addition of growth medium. Notably and unexpectedly, the combination of 1.5 wt% arginine with 5 wt% or 10 wt% xylitol caused the greatest improvement in preventing pH reduction, which is glycolysis by S. mutans active function. Table 5 illustrates that the combination of 1.5% arginine with 5% or 10% xylitol showed improvement compared to solution cells with arginine or xylitol alone.
[0448] table 5
[0449] Table 5 (wt%) (total AUC of ΔpH)
[0450] Control (without arginine or xylitol) 29.5 1.5% Arginine 28.9; Δ (relative to control) = 0.6 1% Xylitol 27.8; Δ (relative to control) = 1.7 5% Xylitol 25.3; Δ (relative to control) = 4.2 10% Xyl...
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