32 results about "PH reduction" patented technology

A combined rapid acting-long acting insulin formulation has been developed wherein the pH of the rapid acting insulin is decreased so that the long acting glargine remains soluble when they are mixed together. In the preferred embodiment, this injectable basal bolus insulin is administered before breakfast, provides adequate bolus insulin levels to cover the meal, does not produce hypoglycemia after the meal and provides adequate basal insulin for 24 hours. Lunch and dinner can be covered by two bolus injections of a fast acting, or a rapid acting or a very rapid acting insulin. As a result, a patient using intensive insulin therapy should only inject three, rather than four, times a day. Experiments have been performed to demonstrate the importance of the addition of specific acids to hexameric insulin to enhance speed and amount of absorption and preserve bioactivity following dissociation into the monomeric form by addition of a chelator such as EDTA. As shown by the examples, the preferred acids are aspartic, glutamic and citric acid. These are added in addition to a chelator, preferably ethylenediaminetetraacetic acid (EDTA). The results show that the citric acid formulation was more effective at dropping the blood glucose rapidly than the identical rapid acting formulation prepared with HCl in swine. Charge masking by the polyacid appears to be responsible for rapid insulin absorption. EDTA was not effective when used with adipic acid, oxalic acid or HCl at hastening the absorption of insulin. These results confirm the results seen in clinical subjects and patients with diabetes treated with the rapid acting insulin in combination with citric acid and EDTA.

A pH increasing material is placed in contact with the surface of an initial comminuted meat product. This contact with the pH increasing material increases the pH of the initial meat product to produce an intermediate meat product. The method also includes the step of removing the pH increasing material and preferably applying a driving force to the intermediate, pH increased meat product. The method may also include placing a pH lowering gas at a neutralizing pressure in contact with the surface of the intermediate meat product to decrease the pH of the meat product back to a final level.

A water treatment system includes a circulation pump and a chlorine-generating electrolytic cell in fluid communication with a main body of water. When mineral deposits foul the generator, water is stagnated within the electrolytic cell and a minimal amount of a pH-reducing agent is added to remove the mineral deposits. The pH-reducing agent is admitted on a periodic timed basis or when the pH of the main body of water exceeds a predetermined threshold. Cleaning is accomplished by adding the pH-reducing agent when water in the electrolytic cell is not circulating so that the acid dwells within the electrolytic cell for a sufficient amount of time. Re-activation of circulation through the electrolytic cell causes the pH-reducing agent to enter the main body of water.

A method for injecting or forcing an ammonia-based pH modifying material into the interior of a meat product to raise the pH at one or more points within the interior of the meat product preferably to a pH above approximately 6.0. The ammonia-based pH modifying material may comprise aqueous ammonia (ammonium hydroxide solution) or a gas including some ammonia gas fraction. The temperature of the meat product may be controlled to a temperature near or just below the initial freezing temperature of the meat product during the time that the pH modifying material is injected. pH decreasing materials may be injected into the interior of the meat product either before or after injection the ammonia-based pH modifying material.

The present invention discloses a double-layer coated colon targeting oral preparation consisting of a tablet core or a pill core, an inner coated layer and an outer coated layer. The tablet core or the pill core is made from pharmic acceptable auxiliary material. The inner coated layer is chitosan, pectin, guar gum or xanthan. The outer coated layer is acrylic resin which is soluble when pH value is more than 6.5. A double-layer coated colon targeting oral preparation of the present invention not only ensures that drug can still be released at the colon, but also can ensure that the drug is not released inside a stomach and small intestines when the environmental pH value of the colon is reduced, which takes effect of targeting oriented treatment towards the colon disease.

The invention discloses an egg roll containing resistant starch, which comprises wheat flour, white yam composite flour, beaten egg, cane sugar, fructooligosaccharide, mixed oil and water. Compared with the prior art, the egg roll containing resistant starch is made of the important material, white yam added to the traditional egg roll, and the fructooligosaccharide, and accordingly has new health functions under synergism of the white yam and the fructooligosaccharide; and the egg roll has the gastrointestinal assistance health physiological functions of intestinal pH reduction, colorectal cancer prevention, constipation improvement and the like, and is more effective than dietary fibers. The egg roll retains original flavor and characteristics such as fragrance, crispiness and bulkinessof the egg roll; as pectin powder capable of structurally improving the egg roll and isomalto-oligosaccharide capable of reducing sweetness and substituting part of granulated sugar are added, the shortages of the existing egg roll such as low formation rate due to proneness to breakage and over-high sweetness are overcome. In addition, production equipment is simple, and investment scale is small.

The invention discloses a traditional Chinese medicine feed additive improving the quality of fresh water aquiculture animal and a preparation method for the traditional Chinese medicine feed additive, and belongs to the field of aquiculture feed additives. The traditional Chinese medicine feed additive comprises the following components: astragalus, turmeric, hawthorn, orange peel, shizandra berry and liquorice. The invention further discloses the method for preparing the traditional Chinese medicine feed additive. The method comprises the following steps: weighing the components according to weight matching; smashing, screening and mixing the components to obtain the traditional Chinese medicine feed additive. The traditional Chinese medicine feed additive can reduce pH reduction speed after cultured fish is killed, improves muscular system water power, remarkably improves flavor substances of muscle free amino acid, inosine monophosphate and intramuscular fat content, can efficiently improve the commodity value of the cultured fish, and has a significant application prospect in aquiculture.

The present invention provides a composition of dietary fiber supplements for satiety enhancement and appetite suppression in treatment of overweight, obesity, or eating disorders. The composition of the dietary fiber supplements consist of at least one cationic polymer and at least one anionic polymer. The cationic polymers and the anionic polymers in the composition can be dissolved or dispersed in an aqueous solution. When the pH of the aqueous solution is lowered, such as the solution is ingested into the stomach with a gastric pH environment or the aqueous solution is added with some acidifying agents, the aqueous solution will turn into a gel. The formation of a gel from the aqueous solution after it being ingested into the stomach before a meal would provide a satiety enhancement and appetite suppression effect.

Disclosed is a new method, and a system, for increasing the pH of a composition applied on teeth and/or gums. The composition is gelable under the influence of a pH change. The pH change typically is a pH increase in the event of a direct pH-triggered gelation. The pH change typically is a pH decrease in the event of gelation induced by ions, such as calcium ions, released from a pH-sensitive carrier. The device comprises a dispensing unit for the composition, a distal end of which is adapted to apply said substance onto teeth or gums. The device further comprises an electrode system comprising first and second electrodes, the first electrode being adapted to be held against the composition at a location at or near teeth or gums, and the second electrode being adapted to be held against the composition at a location away from teeth or gums, The electrode system is adapted so as to provide an electrical potential difference of 1.5 to 10 Volt between the electrodes.

The invention discloses a biological deodorant. The biological deodorant comprises, by weight, 10-15 parts of photosynthetic bacteria, 30-50 parts of lactic acid bacteria, 20-30 parts of microzyme, 10-20 parts of nitrobacteria and 10-15 parts of actinomyces. The invention also discloses a preparation method of the above biological agent. The biological deodorant can absorb and convert ammonia gas and other stink gases, has fast effect and strong adaptability. Self fermentation acid production of the original biological agent makes the pH value be reduced to 3-4, so substances generating stink are absorbed and decomposed, thereby the deodorization effect is efficient and stable; and generation of stink is fundamentally inhibited to a certain degree with colonization of microbes in the biological agent in a stink source.

The invention belongs to the field of medical materials, and particularly relates to a biodegradable material and a preparation method and application thereof. The biodegradable material is prepared with PLLA (poly-L-lactic acid) and RAPA (rapamycin) as raw materials; the mass ratio of PLLA to RAPA is (900-1100):(1.2-2.5); the molecular weight of PLLA is 600,000-1,000,000. By blending the elasticdegradable polymer PLLA with the rigid polymer RAPA in a certain proportion range, the fully-degradable polymer material having different flexibility degrees and strength cycles is obtained; the biodegradable material also has the effect of relieving inflammatory reaction, RAPA also serves as a prodegradant, local pH reduction caused by the acidity of terminal carboxyl groups of a degradation product in the in-vivo degradation process of a polylactic acid polymer is relieved, and the incidence rate of aseptic inflammation is reduced.

The present invention relates to a method for producing a fermented food or drink product, including: adding a strain of lactic acid bacteria which belongs to Lactobacillus brevis to a medium containing 50% or more by mass of a vegetative raw material, and either 0.2 to 2.0% by mass of malic acid or 2.0 to 20.0% by mass of fructose, the medium having a pH of 5.0 to 7.0, and the content of the vegetative raw material being expressed by a content thereof in its natural state; and performing fermentation at least until the termination of a logarithmic growth phase of the strain of lactic acid bacteria, wherein an acid or a strain of lactic acid-producing bacteria is additionally added to the medium at any point in time from the initiation of the fermentation until the termination of the logarithmic growth phase, so as to perform the fermentation with a rate of pH reduction of the medium being 0.01 to 0.3 (1/hour) during a time from the initiation of the fermentation until the termination of the logarithmic growth phase, and with a pH of the medium being 3.3 to 4.6 at the time the fermentation is completed.

The invention discloses a method for producing citric acid fermentation liquor by two-stage fermentation. The method comprises the following steps: (1) Aspergillus niger mouldy bran spores are taken,sterile water is added in order to prepare a spore suspension, the suspension is inoculated to a seed tank and culture is carried out for 16-24 hours, in order to obtain seed liquid; (2) corn liquefaction liquid whose volume is 8-12% of effective volume of a fermentation cylinder is added into the fermentation cylinder, and the temperature is reduced to 35-39 DEG C; (3) seed liquid obtained in thestep (1) is inoculated to the fermentation cylinder, and cultivation is carried out for 2-8 hours; (4) a sugar solution whose volume is 60-64% of the effective volume is added into the fermentation cylinder for cultivation, and when reducing sugar is below 5g/L, fermentation is stopped, and citric acid fermentation liquor is obtained. The two-state cultivation avoids influences of pH reduction inearly stage of fermentation and concentration of nutrients on growth of fungi, improves utilization efficiency and utilization rate of starchiness raw materials, reduces residual sugar of fermentation, and improves conversion rate of saccharic acid; the method can improve acid production rate and shorten fermentation period.

A water treatment system and method reduces the pH level of a waste stream from an unacceptably high level with maximum efficiency and safety, and minimum costs and labor. The system includes a pH control system that detects a pH level of the waste stream. An acid discharge unit including a source of acid and an acid feeding mechanism is activated and deactivated by the pH control system according to the pH level of the waste stream. A housing contains the acid discharge unit and at least part of the pH control system. The acid feeding mechanism may feed dry acid directly to the waste stream or premix the dry acid with water to form a wet acidic solution that is fed into the waste stream. A mixing tank may be provided downstream of the housing to serve as an area for mixing acidic materials from the acid discharge unit with the waste stream prior to discharge from the plant.

The invention relates to a chemical reagent, specifically to a novel sewage treating agent on the aspect of sewage treatment. The novel sewage treating agent is prepared from the following raw materials in parts by weight: 20-40 parts of sodium sulfate, 10-20 parts of polyacrylamide, 5-15 parts of aluminium chloride and 20-50 parts of diatom ooze. The novel sewage treating agent overcomes the shortcomings in the existing sewage treatment methods; polymerization ferric chloride selected by the sewage treating agent can be dissolved in water easily, so that excellent coagulation effect, high product stability, wide applicable pH value range, and low pH reduction of water after treatment are achieved; meanwhile, inorganic substances and organic substances are synergistically adopted as a coagulant, so that the novel sewage treating agent achieves an excellent flocculation effect; and in addition, the novel sewage treating agent has the advantages of high purification speed, good effect, environment protection, no toxic, and the like.

The application, which belongs to the technical field of enzyme preparations for the food industry, particularly relates to a preparation method for improving the refining effect of an enzyme preparation for the food industry. The method comprises the following steps: flocculating an enzyme maturation fermented mash for food industry; performing filtering by adopting a filter aid; carrying out ultrafiltration concentration; carrying out refined filtration and the like. The inventor believes that when the industrial enzyme preparation is detected according to the existing national standard, thequantity of lactic acid bacteria in the filtrate cannot be detected when the standard of the total number of bacteria is met, so that secondary fermentation of lactic acid bacteria exists in the subsequent preservation and storage process and thus the phenomena of barrel expansion, turbidity and pH reduction easily occur in the product storage process. Therefore, the inventor further improves therefining process of the fermentation liquor; the product quality stability of the industrial enzyme preparation product in the subsequent storage and preservation processes is guaranteed by reducingthe influence of lactic acid bacteria. The preparation method has the great practical value and popularization and application significance.

The invention provides a bacteriostatic compounding agent applied to a metal cutting fluid, the bacteriostatic compounding agent comprises the following components by weight: 18-22% of an auxiliary agent; 22-28% of an alcohol amine; 26-32% of a ternary carboxylic acid rust preventive agent; 12-18% of a rust inhibitor and 8-12% of water. The invention also provides a preparation method and application of the bacteriostatic compounding agent applied to the metal cutting fluid. The finished product liquid of the compounding agent is colorless, uniform and fine, and is not stratified by centrifugation and standing; at the same time, the compounding agent has very good dispersibility in water, the compounding agent is mixed with a small amount of alcohol amine and an aqueous solution to rapidlyform a stable stock solution, the compounding agent is mixed with a release agent and other components to form a stable equilibrium system, and the compounding agent is very easy to formulate. Compared with the prior art, the compounding agent is has the following advantages: 1) alkali reserve is large, the change of the pH of the use liquid with time is small, the problems of pH reduction and odor can be effectively solved; 2) the bacteriostatic property of the use liquid system is improved; and 3) the product is mild and non-irritating.