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Biodegradable material and preparation method and application thereof

A biodegradable material and biological technology, applied in the field of medical materials, can solve the problems of slow degradation rate of L-lactic acid materials, unsatisfactory degradation rate, and limited use range, so as to improve labor productivity, increase reaction yield and product quality, and react short time effect

Active Publication Date: 2018-10-12
CHONGQING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Judging from the current polymer degradable stents, the degradation rate of the L-polylactic acid material is too slow, and the degradation rate cannot meet the needs of the application, and the autophagy reaction caused by the implantation of the stent material and the restenosis of the blood vessel after the stent is introduced , which limits the use of the material to

Method used

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  • Biodegradable material and preparation method and application thereof
  • Biodegradable material and preparation method and application thereof
  • Biodegradable material and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] The preparation of embodiment 1 biodegradable material

[0056] The mass ratio of PLLA to RAPA is 1000mg: 1.5mg;

[0057] Reagent name

M (molecular weight)

n( / mmol)

Actual value (mg)

DCC(N,N-Dicyclohexylcarbodiimide)

206.18

20e.q.,0.2 / 7

60

DMAP (4-Dimethylaminopyridine)

122.17

20e.q.,0.2 / 7

40

DCM (dichloromethane)

84.93

200mL

[0058] See figure 1 , add N,N-dicyclohexylcarbodiimide and 4-dimethylaminopyridine to dichloromethane according to the above ratio and mix thoroughly to obtain a reaction solution; mix PLLA and RAPA according to the above mass parts and then add it to the above preparation In the reaction solution, and then fully stirred by a rotator for 7-10 days, because dichloromethane is highly volatile and ventilation safety must be paid attention to, and sufficient stirring also makes the two substances fully mixed to achieve chain extension modification. The reaction temp...

Embodiment 2

[0060] The preparation of embodiment 2 biodegradable materials

[0061] The mass ratio of PLLA to RAPA is 1100mg: 2.5mg;

[0062]

[0063]

[0064] The specific preparation method is prepared according to the method of Example 1.

Embodiment 3

[0065] The preparation of embodiment 3 biodegradable materials

[0066] The mass ratio of PLLA to RAPA is 900mg: 1.2mg;

[0067] Reagent name

[0068] The specific preparation method is prepared according to the method of Example 1.

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Abstract

The invention belongs to the field of medical materials, and particularly relates to a biodegradable material and a preparation method and application thereof. The biodegradable material is prepared with PLLA (poly-L-lactic acid) and RAPA (rapamycin) as raw materials; the mass ratio of PLLA to RAPA is (900-1100):(1.2-2.5); the molecular weight of PLLA is 600,000-1,000,000. By blending the elasticdegradable polymer PLLA with the rigid polymer RAPA in a certain proportion range, the fully-degradable polymer material having different flexibility degrees and strength cycles is obtained; the biodegradable material also has the effect of relieving inflammatory reaction, RAPA also serves as a prodegradant, local pH reduction caused by the acidity of terminal carboxyl groups of a degradation product in the in-vivo degradation process of a polylactic acid polymer is relieved, and the incidence rate of aseptic inflammation is reduced.

Description

technical field [0001] The invention belongs to the field of medical materials, and in particular relates to a biodegradable material and its preparation method and application. Background technique [0002] Biodegradable and absorbable materials have been studied in the biomedical field for more than forty years. The application principle of biodegradable materials in the medical field is to degrade macromolecular substances into small molecular substances that are not harmful to the body through hydrolysis and enzymolysis under the physiological conditions of the body, or small molecular substances degrade by themselves in the body, and finally It is completely absorbed and excreted through the metabolism of the body, and has no toxic side effects on the body. Biodegradable materials have been widely used in surgical sutures, artificial skin, bone fixation materials, and drug release agents in vivo. The most common biomaterials mainly include polymer materials such as po...

Claims

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Application Information

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IPC IPC(8): C08G63/91A61L31/06A61L31/16A61L31/14
CPCA61L31/06A61L31/148A61L31/16A61L2300/216A61L2300/41C08G63/912C08L67/04
Inventor 王贵学罗力吴伟尹铁英王溢
Owner CHONGQING UNIV
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