Oral care product

A technology for oral care and composition, which is applied in the field of oral care compositions, and can solve problems such as irritation, reduction of formulation efficacy, and poor affinity for tooth surfaces

Pending Publication Date: 2021-10-22
COLGATE PALMOLIVE CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, there was previous concern that basic amino acids could raise the pH and facilitate the dissociation of calcium ions, which could react with fluoride ions to form insoluble precipitates
Also, higher pH may cause irritation
[0003] However, at neutral or acidic pH, systems employing arginine bicarbonate may release carbon dioxide, causing swelling and bursting of the container
In addition, lowering the pH to neutral or acidic conditions would be expected to reduce the efficacy of the formulation, since arginine may form insoluble arginine-calcium complexes that have less affinity for the tooth surface, and lowering the pH would reduce Any effect the preparation may have on buffering cariogenic lactic acid in the mouth

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach

[0152] 1.1.1. Composition 1.1, wherein the acid to form a salt of the alkaline amino acid is a carboxylic acid.

[0153] 1.1.2. Composition 1.1, where the acid to form a salt of the alkaline amino acid is an inorganic acid, wherein the inorganic acid is not phosphoric acid or sulfuric acid.

[0154] 1.1.3. Composition 1.1.1, wherein the carboxylic acid is selected from the group consisting of citric acid, lactic acid, glycolic acid and acetic acid, succinic acid, fumaic acid or a combination thereof.

[0155] 1.1.4. Composition 1.1.2, wherein the inorganic acid is not phosphoric acid or sulfuric acid, for example, when the particles are calcium carbonate, the inorganic acid is sodium hydrochloric acid or sodium pyrophosphate.

[0156] 1.1.5. Composition 1.1.2, wherein the inorganic acid is not phosphoric acid or sulfuric acid, wherein the inorganic acid is hydrochloric acid or sodium pyrophosphate only when calcium carbonate is present.

[0157] 1.1.6. Composition 1.1.2, there is a...

Embodiment 1

[0422] Example 1: Preparation

[0423] Optimized arginine toothpaste preparations were prepared using the following ingredients:

[0424] Table A

[0425]

[0426]

[0427] Table A (continued)

[0428]

[0429]

[0430] Table B

[0431]

[0432]

[0433]

[0434] Table B (continued)

[0435]

[0436]

Embodiment 2

[0438] Acids produced by oral bacteria can cause dental enamel dehydration and the development of dental caries over time. The arginine from the beneficial oral symbiotic via the decomposition metabolism of the arginine dethozyme pathway causes the alkali to produce (ammonia), which contributes to the prevention of neutralizing and tooth decaying in the plaqueous acid. Evaluation of Gordococcus Soclas in vitro - a known arginine decomposing bacteria to metabolize different formulations in different formulations. The ammonia produced by the split permeability method of 670 nm using a colored ammonia test method.

[0439] As shown in Table C below, in the step-by-ammonia production of ammonia production, an arginine-containing dentifrust formulation results in a negative control-containing 0.6% phosphoric acid but unvinoic acid solution significantly higher solution. Ammonia production. Surprisingly, the choice of acid used in the formulation seems to play in the ability of Gordonyl...

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Abstract

This invention relates to oral care compositions, for example comprising a salt of a basic amino acid having a pH in solution of less than 7.5, an abrasive having a pH in solution of less than 7.5, and a fluoride ion source, and an acid selected from the group consisting of: a carboxylic acid (e.g., citric acid, lactic acid, glycolic acid, acetic acid, succinic acid, or fumaric acid), and an inorganic acid, wherein the inorganic acid is not phosphoric acid or sulfuric acid (e.g., wherein the inorganic acid is hydrochloric acid or sodium acid pyrophosphate), and to methods of using and of making these compositions.

Description

Technical field [0001] The present invention relates to an oral care composition, such as a salt comprising an effective amount of an alkaline amino acid, wherein the salt is a salt of the following substance: (a) carboxylic acid (e.g., citric acid, lactic acid, glycolic acid, acetic acid, succinic acid or Fumaric acid) or inorganic acid, wherein the inorganic acid is not phosphoric acid or sulfuric acid (e.g., wherein the inorganic acid is hydrochloric acid or sodium pyrophosphate); and (B) basic amino acids; effective amount of soluble fluoride Salt, for example, sodium fluorinated sodium fluoride, sodium fluoride, for example from about 100 to 25,000 ppm, for example from fluoride ions, such as from about 750 to about 2000 ppm; particulate material, for example, natural calcium carbonate (NCC) (eg,, The average particle size is 3-7 microns) or dicium phosphate (for example, dihydrate), which is less than about 7.5 in the non-buffered solution, for example from about 6.5 to abou...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/21A61K8/24A61K8/25A61K8/36A61K8/44A61Q11/00
CPCA61K8/44A61K8/36A61K8/21A61K8/24A61K8/25A61Q11/00
Inventor 徐云斯泰西·拉文德卢恰娜·林奥迪马龙佐耶·斯库尔洛斯马尼什·曼德哈尔
Owner COLGATE PALMOLIVE CO
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