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Curcumenol tablet and preparation method thereof

A curditol tablet and curditol technology, which is applied in the directions of pill delivery, pharmaceutical formulations, and non-active ingredients medical preparations, etc., can solve the problems of complex preparation process of curcumitol dosage forms, achieve good dissolution effect in vivo, and loose requirements. , The effect of tablet process is simple

Pending Publication Date: 2022-08-02
GUILIN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to provide a curcumol tablet capable of treating cancer and a preparation method thereof. The quality of the tablet is stable, the drug loading capacity is large, the dissolution effect in the body is good, and the preparation process of the tablet is mature, the requirements are simple, and it is easy to produce , to solve the current relatively complicated problem about the preparation process of curcumol dosage forms

Method used

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  • Curcumenol tablet and preparation method thereof
  • Curcumenol tablet and preparation method thereof

Examples

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Comparison scheme
Effect test

Embodiment 1

[0032] A kind of preparation of curcumamol tablet, the raw material consumption is as follows (1000 tablet consumption):

[0033] Curcumamol: 40g

[0034] Lactose monohydrate: 221g

[0035] Corn starch (added): 30g

[0036] Hydroxypropyl methylcellulose: 7.5g

[0037] Magnesium stearate: 1.5g

[0038] Purified water: 40ml.

[0039] The preparation method of curcumamol tablet is specifically:

[0040] Take 40g of curcumol (main drug) in the prescribed amount and grind it with a pulverizer, and pass it through a screen with an aperture of less than 100um;

[0041] Put sieved curditol, 30 g of corn starch (disintegrant added), and 154.7 g of lactose monohydrate (filler) accounting for 70% of the total lactose monohydrate into a wet granulator, stirring and mixing, and the stirring paddle is The speed is 100RPM and the flying knife is running at 2000RPM for 120 seconds;

[0042] Add 40ml of purified water and 7.5g of hydroxypropyl methylcellulose (adhesive) and mix the prep...

Embodiment 2

[0054] A kind of preparation of curcumamol tablet, the raw material consumption is as follows (1000 tablet consumption):

[0055] Curcumamol: 36g

[0056] Lactose monohydrate: 227g

[0057] Corn starch (added): 30g

[0058] Povidone: 4g

[0059] Magnesium stearate: 3g

[0060] Purified water: 40ml.

[0061] The preparation method of curcumamol tablet is specifically:

[0062] Take 36g of curcumol (the main drug) in the prescribed amount and grind it with a pulverizer, and pass it through a screen with an aperture of less than 100um;

[0063] Put sieved curditol, 30 g of corn starch (disintegrant added), and 158.9 g of lactose monohydrate (filler) accounting for 70% of the total amount of lactose monohydrate into a wet granulator, stirring and mixing, and the stirring paddle is The speed is 100RPM and the flying knife is running at 2000RPM for 120 seconds;

[0064] Add 40ml of purified water and 4g of povidone (adhesive) and mix the prepared adhesive. After the stirring pa...

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Abstract

The invention discloses a curcumenol tablet and a preparation method thereof. The curcumenol tablet is prepared from the following raw materials in parts by weight: 36-44 parts of curcumenol, 220-240 parts of a filler, 4-7.5 parts of an adhesive, 30 parts of a disintegrating agent and 1.5-3 parts of a lubricant. The preparation method comprises the following steps: uniformly mixing curcumenol, the disintegrating agent and 60-70% of the filler, adding the prepared adhesive to prepare a soft material, and granulating to obtain wet granules; and drying the prepared wet particles, adding the remaining 30-40% of the filler and the lubricant, carrying out uniform mixing on the whole particles, and carrying out tabletting to obtain the curcumenol tablets. The curcumenol tablet disclosed by the invention can be used for treating cancers and has a very good inhibiting effect on tumors. As a tablet, the composition is simple, the main drug accounts for more than 10%, the finished product is stable in quality, large in drug loading capacity, good in in-vivo dissolution effect and convenient to take, carry and transport, the preparation method is simple, the process is mature, the yield is large, the cost is low, hygienic standards are easy to reach, and mechanized production can be achieved.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a curditol tablet and a preparation method thereof. technical background [0002] Curcumol, chemically classified as sesquiterpene, with molecular formula C 15 H 24 O 2 , Chinese alias turmeric, is a potential anti-tumor drug, it has obvious inhibitory effect on tumor cells in vitro and tumor in transplanted mice. The anti-cancer mechanism may be related to inhibiting the growth of tumor cells and RNA synthesis, enhancing the specific Sexual immunity and produce significant immune protection. [0003] The chemical structural formula of curcumol is as follows: [0004] . [0005] CN107126417A A kind of curcuma alcohol solid dispersion and oral solid preparation thereof, the publication date is 2017.09.05, in order to solve the problem that the in vitro dissolution of curcumitol is too low, the preparation technology of solid dispersion is ado...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K47/26A61K47/38A61K47/32A61K47/36A61K31/35A61P35/00
CPCA61K9/2095A61K9/2018A61K9/2054A61K9/2027A61K9/2059A61K31/35A61P35/00Y02A50/30
Inventor 王娟陈旭李林峻周璐炜窦童韩梦洁刘国翔李肖娟王炎唐炜丁虹芳刘张弛余馨媛刘以撒
Owner GUILIN MEDICAL UNIVERSITY
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