Application of cnidium oil in preparing medicine for treating cerebral thrombus and headache

A technology of chuanxiong oil and chuanxiong, which is applied in the application field of medicine, can solve the problems of long intermittent period, unsatisfactory curative effect, many adverse reactions, etc., and achieves high export profit, good medicinal prospect and strong medicinal effect. Effect

Inactive Publication Date: 2006-05-31
SICHUAN HEZHENG PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

②Drug therapy: Commonly used are calcium channel antagonists (such as Sibeline, Nimotop, etc.), β-receptor blockers ③ (such as propranolol, etc.), histamine receptor antagonists (such as phenthiazine, formazan, etc.) lysergide, etc.), but the curative effect is not ideal, only 50-70% are effective, and many patients have a long interval between attacks, long-term drug prevention, and many adverse reactions
The traditional steam distillation method is generally used, and the extraction rate is also low.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Embodiment 1: Chuanxiong oil soft capsule

[0034] Efficacy of the new drug: analgesia, sedation, reduction of vascular resistance, increase of cerebral blood flow, anti-thrombosis.

[0035] Indications: Treatment of vascular nerve headache, cerebral thrombosis, and cerebrovascular sclerosis.

[0036] Applicable amount: 300-1500 mg

[0037] Made with a single flavor. Ligusticum chuanxiong medicinal materials were dried, pulverized, passed through an 8-mesh sieve, and washed with supercritical CO 2 Extraction, extraction temperature 46°C, extraction pressure 25Mpa, CO 2 The flow rate is calculated as 20Kg / hr per kilogram of crude drug of Chuanxiong Rhizoma Chuanxiong. After extracting in the separation tank for 100 minutes, the collected extracts are combined, placed in a volatile oil separator, and left to stand at room temperature for 5 hours, and the oil layer is centrifuged (3000 rpm). Put the obtained Chuanxiong oil in a brown bottle and seal it for storage; amo...

Embodiment 2

[0039] Embodiment 2: Chuanxiong oil tablet

[0040] Made with compound. Choose supercritical CO 2 The extracted chuanxiong oil and angelica oil are prepared according to the ratio of 1:0.1-20.

[0041] The present invention can also choose supercritical CO 2 The extracted chuanxiong oil and angelica oil are made into medicine according to the ratio of 1:0.1-30 or borneol according to the ratio of 1:1-500.

[0042] The present invention has brought into play new medical application to Chinese medicine Rhizoma Chuanxiong, has opened up a new application field, adopts supercritical CO 2 The extracted Chuanxiong oil is safe and non-toxic, has strong medicinal effects, and has a good medicinal prospect, and Chuanxiong has abundant raw materials, low price, simple extraction process, low cost of making traditional Chinese medicine, high export profit, and can be made into various dosage forms .

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PUM

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Abstract

The invention discloses a method using supercritical CO 2 The application of the extracted Chuanxiong oil in the preparation of the medicine for treating headaches, which is used in single flavor or compound mode in pharmacy, the present invention exerts a new medical application to the traditional Chinese medicine Chuanxiong, opens up a new application field, adopts supercritical CO 2 The extracted Chuanxiong oil is safe and non-toxic, has strong medicinal effects, and has good medicinal prospects. Moreover, Chuanxiong has abundant raw materials, low price, simple extraction process, low cost of making Chinese patent medicines, high export profits, and can be made into various dosage form.

Description

Technical field: [0001] The present invention relates to the purposes of Chuanxiong oil, especially relate to the use of supercritical CO 2 Application of extracted Chuanxiong oil in preparation of medicine for treating headache. Background technique: [0002] Vascular headache, including migraine, cluster headache and non-migrainous vascular headache, is a very common clinical headache. [0003] In recent years, many developed countries in the world have carried out large-scale epidemiological investigations on vascular headache according to HIS (International Headache Society) standards, in order to understand the impact of the disease on public health, individuals and society, and to find high-risk groups at the same time. Provide clues for future treatment and public health. The findings showed that: vascular headache is a common high incidence. In western countries, the prevalence rate is: 10-18% for females and 4-6% for males (such as: 17.6% for American females and...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/236A61K125/00A61P25/06A61P29/00A61P7/02
Inventor 刘传捷胡坦莲张廷模
Owner SICHUAN HEZHENG PHARM CO LTD
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