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Application of ligusticum oil in preparation of medicine for treating cerebral thrombosis

A technology of Chuanxiong oil and cerebral thrombosis, which is applied in the application field of preparing medicines for treating cerebral thrombosis, can solve problems that have not been reported before, and achieve the effects of strong drug effect, good medicinal prospects, and high export profits

Inactive Publication Date: 2006-12-27
SICHUAN HEZHENG PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the use of Chuanxiong oil in the preparation of medicines for the treatment of cerebral thrombosis has never been reported.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Embodiment 1: Chuanxiong oil soft capsule

[0032] Efficacy of the new drug: analgesia, sedation, reduction of vascular resistance, increase of cerebral blood flow, anti-thrombosis.

[0033] Indications: Treatment of vascular nerve headache, cerebral thrombosis, and cerebrovascular sclerosis.

[0034] Applicable amount: 300-1500 mg

[0035] Made with a single flavor. Ligusticum chuanxiong medicinal materials were dried, pulverized, passed through an 8-mesh sieve, and washed with supercritical CO 2 Extraction, extraction temperature 46°C, extraction pressure 25Mpa, CO 2 The flow rate is calculated as 20Kg / hr per kilogram of crude drug of Chuanxiong Rhizoma Chuanxiong. After extracting in the separation tank for 100 minutes, the collected extracts are combined, placed in a volatile oil separator, and left to stand at room temperature for 5 hours, and the oil layer is centrifuged (3000 rpm). Put the obtained Chuanxiong oil in a brown bottle and seal it for storage; amo...

Embodiment 2

[0037] Embodiment 2: Chuanxiong oil tablet

[0038] Made with compound. choose supercritical CO 2 The extracted chuanxiong oil and angelica oil are prepared according to the ratio of 1:0.1-20.

[0039] The present invention can also choose supercritical CO 2 The extracted chuanxiong oil and angelica oil are made into medicine according to the ratio of 1:0.1-30 or borneol according to the ratio of 1:1-500.

[0040] The present invention has exerted new medical application to the Chinese medicine Rhizoma Chuanxiong, has opened up a new application field, adopts supercritical CO 2 The extracted Chuanxiong oil is safe and non-toxic, has strong medicinal effects, and has a good medicinal prospect, and Chuanxiong has abundant raw materials, low price, simple extraction process, low cost of making traditional Chinese medicine, high export profit, and can be made into various dosage forms .

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Abstract

An application of Chuan-xiong oil extracted from Chuan-xiong rhizome by supercritical Co2 in preparing the medicine for treating cerebral thrombus is disclosed.

Description

Technical field: [0001] The present invention relates to the purposes of Chuanxiong oil, especially relate to the use of supercritical CO 2 Application of extracted Chuanxiong oil in preparation of medicine for treating cerebral thrombosis. Background technique: [0002] Cerebral thrombosis, also known as arteriosclerotic cerebral infarction, refers to the formation of thrombus on the basis of cerebral artery intimal lesions, resulting in stenosis or occlusion of the vessel lumen, obstruction of blood flow, resulting in acute cerebral blood supply insufficiency and local brain tissue necrosis. [0003] The common cause of this disease is that cerebral atherosclerosis, hypertension, hyperlipidemia, and diabetes can often promote the development of arteriosclerosis. Other causes include various cerebral arteritis, moyamoya disease, connective tissue disease, polycythemia vera, hypercoagulable state, etc. Atherosclerosis is most likely to occur at the bifurcations and bends o...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/236A61K9/02A61K9/16A61K9/08A61K9/10A61K9/20A61K9/48A61P7/02A61P9/10A61K125/00
Inventor 刘传捷胡坦莲张廷模
Owner SICHUAN HEZHENG PHARM CO LTD
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