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Total alkaloid composition from plant and its pharmaceutical preparation

A technology of total alkaloids and alkaloids, applied in drug combinations, plant raw materials, plant/algae/fungus/moss components, etc.

Inactive Publication Date: 2007-01-03
张平
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After searching the FDA pharmaceutical resource information by active ingredients, no records can be found. Therefore, it can be considered that there are currently no Boluohui, Celandine, Xueshuicao, and Feilongzhangxue with chelerythrine as the main component at home and abroad. Equal total alkaloid preparations in clinical application

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0072] Take 1kg of boluohui medicinal materials, cut into 1-2cm pieces, add 8 liters of water to soak, adjust the pH of the solution to 2.0-3.0 with hydrochloric acid, stir frequently, soak for 16-24h, and press filter to obtain 5 liters of extract; Soak 5 liters of aqueous solution with a pH of 2.0-3.0 for 16 hours, and press filter to obtain 5 liters of extract. Combine the two extracts, add concentrated NaOH solution, adjust the pH of the extract to 6.0-7.0, let stand overnight to precipitate the alkaloid; filter and collect the filtrate; add NaOH solution to the filtrate, adjust the pH of the filtrate to 9.0-9.5 , and add NaCl, make the NaCl concentration in the filtrate reach 3.8%, stir to make NaCl dissolve completely, let stand overnight, make alkaloid precipitation; Filtrate and collect precipitation, get the total alkaloid precipitate of plant origin of the present invention, yield (with Constant weight product) is 1.5%. After testing, in the obtained precipitate, che...

Embodiment 2

[0080] Take 2kg of boluohui medicinal materials, cut them into 1-2cm pieces, put them into the extraction container, add 8 liters of methanol, then add 8g of citric acid and 8ml of hydrochloric acid into the extraction container, soak for 16-24h, and filter with suction to obtain the extract Extract 5 liters; add 5 liters of methanol to the container, add 5 g of citric acid, 5 ml of hydrochloric acid, soak for 8-12 hours, and filter with suction to obtain 5 liters of extract. Combine the two extracts, adjust the pH to 6.0-7.0 with concentrated alkali solution, and let it stand overnight to precipitate the alkaloid; filter and collect the filtrate; continue to adjust the pH of the filtrate to 9.0-9.5 with concentrated alkali, and add 30% chlorine Zinc chloride solution, make the zinc chloride concentration in the filtrate reach 2%-4%, let it stand overnight, make the alkaloid precipitate, filter and collect the precipitate, get the total alkaloid precipitate of plant origin of t...

Embodiment 3

[0084] Take 1 kg of blood water herbs, cut into 1-2 cm pieces, soak in 8 liters of water, adjust the pH of the solution to 2.0-3.0 with hydrochloric acid, stir frequently, soak for 16-24 hours, and press filter to obtain 5 liters of extract; add 5 liters to the filter residue Soak in an aqueous solution with a pH of 2.0-3.0 for 16 hours, and press filter to obtain 5 liters of extract. Combine the two extracts, add concentrated Na 2 CO 3 Solution, adjust the pH of the extract to 6.0-7.0, let it stand overnight to precipitate the alkaloid; filter and collect the filtrate; add Na to the filtrate 2 CO 3 solution, adjust the pH of the filtrate to 9.0-9.5, and add NaCl to make the NaCl concentration in the filtrate reach 3.8%, stir to completely dissolve the NaCl, and let it stand overnight to precipitate the alkaloid; collect the precipitate by filtration to obtain the plant-derived total biological Alkali precipitate, the yield (in terms of constant weight) is 1.5%. After testi...

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PUM

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Abstract

The present invention discloses a total alkaloid composite from plant has anticancer activity and its extraction process and use as well as medicine preparation containing the composite and its preparation process. The plant is macleaya cordata, greater celandine herb, adnate elder herb or Asiatic toddalia root. Experiment shows that the preparation has powerful effect of suppressing MRP gene expression and excellent effect of suppressing Ara-C to induce the expression of MDRI, and excellent anticancer effect.

Description

[0001] The technical field of the invention [0002] The present invention relates to a plant-derived total alkaloid composition with anticancer activity, its extraction method and use, a pharmaceutical preparation containing the composition and its preparation method. Flying dragon palm blood. Background technique [0003] Alkaloids are one of the main medicinal active ingredients in many plants, and they are also one of the important contents of current Chinese medicine research. [0004] Boluohui, Celandine, Xueshuicao, and Feilongzhangxue are herbal medicines that have not yet been listed in the Pharmacopoeia of the People's Republic of China. Among them, Boluohui, celandine, and blood water grass all belong to the family Papaveraceae, and their scientific names are respectively Macleayacordata (Willd.) R.Br., Chelidonium majus L., Eomecon chionantha Hance, and Feilongzhangxue is a plant of Rutaceae Feilongzhangxue. The root and leaves of palm blood, the scientific name ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4741A61K36/00A61P35/00
Inventor 张平
Owner 张平
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